M. Pharm.

Ms. Swati Gupta joined as Lecturer in the Department of Pharmaceutics, Amrita School of Pharmacy in March 2012. She completed her B.Pharm and M.Pharm from Dr. H S Gour University, Sagar M P in year 2010. She is presently supervising M.Pharm and B.Pharm students in their research projects on formulation development and novel drug delivery systems.


Publication Type: Journal Article

Year of Publication Title


D. V. Pillai, Dr. Sabitha M., and Swati P. Gupta, “Brinzolamide-2-hydroxypropyl beta cyclodextrin complex loaded chitosan nanogel for ocular drug delivery”, International Journal of Pharmaceutical Research, vol. 11, pp. 350-362, 2019.[Abstract]

In this study an inclusion complex between Brinzolamide (BRZ) and 2-Hydroxypropyl Beta Cyclodextrin (2-HP-β-CD) was prepared and incorporated into Chitosan (CS)/Tripolyphosphate (TPP) nanogels to provide sustained release of BRZ with increased retention time in the corneal region. Further to this, an attempt was made to increase the viscosity of the prepared CS/TPP nanogels using CS/PVA (polyvinyl alcohol) biopolymer composite. BRZ, is a second line therapy for glaucoma but suffers from poor aqueous solubility leading to lesser absorption and side effects on its administration in ocular delivery. Thus by increasing the solubility and ocular retention will reduce its frequency of administration and dose followed by increases its absorption.BRZ was complexed with 2-HP-β-CD by solvent evaporation and confirmed by FTIR, XRD and SEM. The complex was incorporated into chitosan nanogels and evaluated for in vitro drug release, ex vivo mucoadhesive and permeation studies.BRZ-2-HP-β-CD complex (1:1 molar ratio) showed improved aqueous solubility and dissolution as compared to BRZ aqueous dispersion. Chitosan nanogels showed particle size of 219.1 ± 0.94 nm, zeta potential of +26.63 ± 0.28 mV, entrapment efficiency of 80.2837 ± 1.7635% having sustained release and following Fickian diffusion. CDNG1 exhibited 15.32 fold increases in the in vitro corneal permeability coefficient in comparison with commercial Brinolar® and exhibited mucoadhesive properties.The results imply the potential of BRZ-HP-β-CD complex loaded Chitosan Nanogels as a novel formulation of BRZ for ocular delivery. © 2019, Advanced Scientific Research. All rights reserved.

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G. Divya, Rajitha Panonnummal, Swati P. Gupta, Dr. Jayakumar Rangasamy, and Sabitha, M., “Acitretin and Aloe-Emodin Loaded Chitin Nanogel for the Treatment of Psoriasis”, European Journal of Pharmaceutics and Biopharmaceutics, vol. 107, pp. 97-109, 2016.[Abstract]

The present study focuses on the development of an effective topical nanogel formulation of two anti-psoriatic drugs; Acitretin (Act) and Aloe-emodin (AE) using natural polymer chitin. Simple regeneration chemistry was used to prepare Chitin Nanogel Systems (CNGs). The developed control chitin (CNGs) nanogels, acitretin loaded chitin nanogels (ActCNGs) and aloe-emodin loaded chitin nanogels (AECNGs) were characterized by DLS, SEM, FTIR, XRD and TG-DTA. The systems were found to be spherical in shape with a size range of 98 ± 10, 138 ± 8 and 238 ± 6 nm having zeta potential values of +28 ± 3, +27 ± 3 and +25 ± 6 mV for CNGs, ActCNGs and AECNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin and aloe-emodin in psoriasis. © 2016 Elsevier B.V.

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Da Subramanian and Swati P. Gupta, “Pharmacokinetic study of amaranth extract in healthy humans: A randomized trial”, Nutrition, vol. 32, pp. 748-753, 2016.[Abstract]

Objective: Nitric oxide (NO) is one of the most important signaling molecules produced within the body. Continuous generation of NO is essential for the integrity of the cardiovascular system. The aim of this study was to assess whether oral intake of a nitrate (NO3 -)-rich dietary supplement (amaranth extract) is able to increase NO3 - and nitrite (NO2 -) levels in blood plasma and saliva of healthy adults. Methods: In the present study, bioavailability and pharmacokinetics of NO3 - and NO2 - from amaranth extract (2 g as single dose) was studied in 16 healthy individuals and compared with placebo in a crossover design. The NO3 - and NO2 - levels in plasma as well as saliva were measured up to 24 h. Results: After administration of amaranth extract, the NO3 - levels in plasma as well as saliva were found to be significantly (P < 0.001) higher than in the placebo group. The NO2 - level in plasma was slightly higher (P < 0.05) in the amaranth group (test group) compared with that in the placebo group, whereas the saliva NO2 - level was significantly high (P < 0.001) in the amaranth extract-treated group than the placebo group. Conclusions: These results clearly indicate that a single oral dose of amaranth extract is able to increase the NO3 - and NO2 - levels in the body for at least 8 h. The increase in NO3 - and NO2 - levels can help to improve the overall performance of people involved in vigorous physical activities or sports. © 2016 Elsevier Inc.

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Anilkumar B. Pillai, Nair, J. Va, Gupta, N. Kb, and Swati P. Gupta, “Microemulsion-loaded hydrogel formulation of butenafine hydrochloride for improved topical delivery”, Archives of Dermatological Research, 2015.[Abstract]

Topical microemulsion systems for the antifungal drug, butenafine hydrochloride (BTF) were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of BTF in oils, surfactants and co-surfactants was evaluated to screen the components of the microemulsion. Isopropyl palmitate was used as the oil phase, aerosol OT as the surfactant and sorbitan monooleate as co-surfactant. The pseudoternary diagrams were constructed to identify the area of microemulsion existence and optimum systems were designed. The systems were assessed for drug-loading efficiency and characterized for pH, robustness to dilution, globule size, drug content and stability. Viscosity analysis, spreadability, drug content assay, ex vivo skin permeation study and antifungal activity assay were performed for the optimized microemulsion-loaded hydrogel. The optimized BTF microemulsion had a small and uniform globule size. The incorporation of microemulsion system into Carbopol 940 gel was found to be better as compared to sodium alginate or hydroxyl propyl methyl cellulose (HPMC K4 M) gel. The developed gel has shown better ex vivo skin permeation and antifungal activity when compared to marketed BTF cream. Thus, the results provide a basis for the successful delivery of BTF from microemulsion-loaded hydrogel formulation, which resulted in improved penetration of drug and antifungal activity in comparison with commercial formulation of BTF. © 2015 Springer-Verlag Berlin Heidelberg

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Swati P. Gupta, Agarwal, Aa, Gupta, N. Kac, Saraogi, Ga, Agrawal, Hd, and Agrawal, G. Pa, “Galactose decorated PLGA nanoparticles for hepatic delivery of acyclovir”, Drug Development and Industrial Pharmacy, vol. 39, pp. 1866-1873, 2013.[Abstract]

The present study explores prospective of surface tailored nanoparticles for targeted delivery of acyclovir along with the interception of minimal side effects. Acyclovir loaded plain and galactosylated poly lectic co glycolic acid (PLGA) nanoparticles were efficiently prepared and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), size, polydispersity index, zeta potential, and entrapment efficiency. The formulations were evaluated for in vitro drug release and hemolysis. Further, biodistribution study and fluorescent microscopic studies were carried out to determine the targeting potential of formulations. SEM revealed smooth morphology and spherical shape of the nanoparticles. In vitro, the galactosylated nanoparticles were found to be least hemolytic and exhibited a sustained release pattern. In vivo studies exhibited an augmented bioavailability, increased residence time and enhanced delivery of acyclovir to the liver upon galactosylation. It may therefore be concluded that galactose conjugated PLGA nanoparticles can be used suitably as vehicles for delivery of bioactives specifically to the hepatic tissues and may be thus exploited in the effective management of various liver disorders. © 2013 Informa Healthcare USA, Inc.

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