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Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis.

Publication Type : Journal Article

Thematic Areas : Medical Sciences, Nanosciences and Molecular Medicine

Publisher : Eur J Pharm Biopharm

Source : Eur J Pharm Biopharm, Volume 107, p.97-109 (2016)

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Keywords : Acitretin, Animals, Anthraquinones, chitin, Drug Carriers, Mice, Microscopy, Electron, Scanning, Nanostructures, psoriasis, Spectroscopy, Fourier Transform Infrared, Swine, Thermogravimetry, X-Ray Diffraction

School : Center for Nanosciences, School of Pharmacy

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2016

Abstract : The present study focuses on the development of an effective topical nanogel formulation of two anti-psoriatic drugs; Acitretin (Act) and Aloe-emodin (AE) using natural polymer chitin. Simple regeneration chemistry was used to prepare Chitin Nanogel Systems (CNGs). The developed control chitin (CNGs) nanogels, acitretin loaded chitin nanogels (ActCNGs) and aloe-emodin loaded chitin nanogels (AECNGs) were characterized by DLS, SEM, FTIR, XRD and TG-DTA. The systems were found to be spherical in shape with a size range of 98±10, 138±8 and 238±6nm having zeta potential values of +28±3, +27±3 and +25±6mV for CNGs, ActCNGs and AECNGs respectively. The in vitro haemolysis assay revealed that all the nanogel systems are blood compatible. The systems exhibited higher swelling and release at acidic pH. The ex vivo skin permeation studies using porcine skin confirmed the higher deposition of the systems at epidermal and dermal layers, which was confirmed further by fluorescent imaging. The in vivo anti-psoriatic activity study using Perry's mouse tail model and skin safety studies confirmed the potential benefit of the system for topical delivery of acitretin and aloe-emodin in psoriasis.

Cite this Research Publication : G. Divya, Panonnummal, R., Gupta, S., Jayakumar, R., and Sabitha, M., “Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis.”, Eur J Pharm Biopharm, vol. 107, pp. 97-109, 2016.

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