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Dr. Muralidharan V.

Research Scientist, Amrita School of Biotechnology, Amritapuri

Qualification: BSc, MSc, Ph.D
​muralidharanv@am.amrita.edu
Ph: 0476 2803126
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Research Interest: Mass Spectrometry and Proteomics, Natural product Lead Discovery, Natural Product-based Drug Discovery, Proteomics and Biomarker Discovery, Snake Venomics and Antivenomics, Venomics

Bio

Dr. Muralidharan V. currently serves as a Research Scientist at the School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri. He holds a Ph.D. in Biotechnology from Amrita Vishwa Vidyapeetham, and his research was mainly focused on characterizing the venom proteome and assessing the antivenom immunological cross-reactivity of medically important snake species from the Western Ghats of India. Before his doctoral studies, he worked as a Research Fellow at Amrita Centre for Nanoscience and Molecular Medicine. Additionally, he was associated with Amrita Centre for Research and Development as a research consultant engaged in various consulting services. In this role, he was involved in developing multiple qualitative and quantitative molecular characterization workflows, for proteins, peptides and therapeutic metabolites, using High Performance Liquid Chromatography, Mass Spectrometry and related tools. Besides, Dr. Muralidharan plays a key role in the successful functioning of the core Mass Spectrometry facility at the school. His research interests include snake venom proteomics and natural product-based drug discovery.

Education

  • 2021: Ph. D. Biotechnology
    School of Biotechnology, Amrita Vishwa Vidyapeetham.
  • 2012: M. Sc. Biotechnology
    School of Biotechnology, Amrita Vishwa Vidyapeetham.
  • 2010: B. Sc. Biotechnology
    CMS College of Science and Commerce, Bharathiar University.
  • 2010: Diploma in Bioinstrumentation
    CMS College of Science and Commerce, Bharathiar University.

 

 

Publications

Journal Article

Year : 2021

Venomics and antivenomics of Indian spectacled cobra (Naja naja) from the Western Ghats

Cite this Research Publication : Vanuopadath, Muralidharan, Dileepkumar Raveendran, Bipin G Nair and Sudarslal Sadasivan Nair. “Can proteomics of snake venoms help drug discovery? A study on the venom of spectacled cobra (Naja naja) from the Western Ghats”, biorxiv, published in Acta Tropica doi: 10.1016/j.actatropica.2022.106324 (2021).

Publisher : bioRxiv

Year : 2021

Ginger Extract Activates Caspase Independent Paraptosis in Cancer Cells via ER stress, mitochondrial Dysfunction, AIF Translocation and DNA Damage

Cite this Research Publication : Divya Nedungadi, Anupama Binoy, Vivek Vinod, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bipin G Nair, Nandita Mishra, Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage Nutrition and cancer, 2021, 73 (1), 147-159.

Publisher : Nutrition and Cancer

Year : 2020

Evaluating the Immunological cross-reactivity of Indian polyvalent antivenoms towards the venom of Hypnalehypnale (hump-nosed pit viper) from the Western Ghats

Cite this Research Publication : Muralidharan Vanuopadath, Dileepkumar Raveendran, Bipin Gopalakrishnan Nair, Sudarslal Sadasivan Nair, “Evaluating the Immunological cross-reactivity of Indian polyvalent antivenoms towards the venom of Hypnalehypnale (hump-nosed pit viper) from the Western Ghats”, bioRxiv, 2020.

Publisher : bioRxiv

Year : 2020

Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4.

Cite this Research Publication : Surbhi Chouhan, Snahlata Singh, Dipti Athavale, Pranay Ramteke, Muralidharan Vanuopadath, Bipin G Nair, Sudarslal Sadasivan Nair, Manoj Kumar Bhat, “Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4.”, Journal of Biosciences, vol. 45, 2020.

Publisher : Journal of Biosciences

Year : 2020

Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurus malabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity

Cite this Research Publication : Muralidharan Vanuopadath, Shaji, S. Korumadath, Dileepkumar Raveendran, Dr. Bipin G. Nair, and Sudarslal Sadasivan Nair, “Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurus malabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity”, International Journal of Biological Macromolecules, vol. 148, pp. 1029 - 1045, 2020.

Publisher : International Journal of Biological Macromolecules

Year : 2020

RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata

Cite this Research Publication : Drishya G., Dr. Jyotsna Nambiar, Sanu K. Shaji, Muralidharan Vanuopadath, Achuthan A., Kumar Abishek, Alias Ashna, Ayesha Sherif, Catherine Joseph, Divya P., Damu Sunilkumar, Chinchu Bose, Dr. Sobha V. Nair, S. Sudarslal, Dr. Geetha Kumar, Lakshmi S., and Dr. Bipin G. Nair, “RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata”, Journal of Biosciences, vol. 45, no. 1, pp. 1-11, 2020.

Publisher : Journal of Biosciences

Year : 2019

Ginger extract activates caspase-independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction

Cite this Research Publication : Nedungadi D, Binoy A, Vinod V, Vanuopadath M, Nair SS, Nair BG, Mishra N. Ginger extract activates caspase-independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage. Nutrition and cancer. 2019:1-13.

Publisher : Nutrition and Cancer, Pp:1-13, 2019

Year : 2019

Phlorotannins from Padina tetrastromatica: structural characterisation and functional studies

Cite this Research Publication : Divya Nair, Muralidharan Vanuopadath, Akshaya Balasubramanian, Akshay Iyer, Shankar Ganesh, Abhishek Nair Anil, Vijesh Vikraman, Prasanth Pillai, Chinchu Bose, Bipin Gopalakrishnan Nair, Jayashree Gopalakrishna Pai & Sudarslal Sadasivan Nair, "Phlorotannins from Padina tetrastromatica: structural characterisation and functional studies.",Journal of Applied Phycology, Volume 31, 3131–3141 (2019). https://doi.org/10.1007/s10811-019-01792-y

Publisher : Journal of Applied Phycology, Volume 31:3131–41, 2019

Year : 2018

Mass spectrometry-assisted venom profiling of Hypnale Hypnale found in the Western Ghats of India incorporating de Novo Sequencing Approaches.

Cite this Research Publication : Muralidharan Vanuopadath, Nithin Sajeev, Athira Radhamony Murali, Nayana Sudish, Nithya Kangosseri, Ivy Rose Sebastian, Nidhi Dalpatraj Jain, Amit Pal, Dileepkumar Raveendran, Dr. Bipin G. Nair, and Sudarslal Sadasivan Nair, “Mass spectrometry-assisted venom profiling of Hypnale hypnale found in the Western Ghats of India incorporating de novo sequencing approaches.”, International Journal of Biological Macromolecules, vol. 118, no. Part B, pp. 1736-1746, 2018

Publisher : International Journal of Biological Macromolecules

Year : 2018

Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa.

Cite this Research Publication : Jayalekshmi H., Omanakuttan, A., Menon, N. D., Muralidharan Vanuopadath, Nair, S. Sadasivan, Corriden, R., Nair, B. G., Nizet, V., and Kumar, G. B., “Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa.”, Sci Rep, vol. 8, no. 1, p. 3437, 2018.

Publisher : Scientific reports

Year : 2017

Mechanistic Understanding of Phenyllactic Acid Mediated Inhibition of Quorum Sensing and Biofilm Development in Pseudomonas Aeruginosa

Cite this Research Publication : M. Chatterjee, D'Morris, S., Paul, V., Warrier, S., Vasudevan, A. Kumar, Muralidharan Vanuopadath, Nair, S. Sadasivan, Dr. Bindhu Paul, Dr. Gopi Mohan C., and Dr. Raja Biswas, “Mechanistic Understanding of Phenyllactic Acid Mediated Inhibition of Quorum Sensing and Biofilm Development in Pseudomonas Aeruginosa”, Appl Microbiol Biotechnol, vol. 101, no. 22, pp. 8223-8236, 2017

Publisher : Appl Microbiol Biotechnol

Year : 2016

Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance

Cite this Research Publication : Parmanand Malvi, Balkrishna Chaube, Shivendra Vikram Singh, Naoshad Mohammad, Vimal Pandey, Maleppillil Vavachan Vijayakumar, Revathy Meenatheril Radhakrishnan, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bipin Gopalakrishnan Nair & Manoj Kumar Bhat, “Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance.”, Cancer Metab, vol. 4, p. 21, 2016.

Publisher : Cancer Metab.

Year : 2016

Identification and Characterization of a Library of Surfactins and Fengycins from a Marine Endophytic Bacillus sp.

Cite this Research Publication : Divya Nair, Muralidharan Vanuopadath, Dr. Jayashree G., Dr. Bipin G. Nair, and Sudarslal Sadasivan Nair, “Identification and characterization of a library of surfactins and fengycins from a marine endophytic Bacillus sp.”, Journal of basic microbiology, vol. 56, no. 11, pp. 1159–1172, 2016

Publisher : Journal of Basic Microbiology

Year : 2016

Lactobacillus Fermentum Secreted Phenyl Lactic Acid Mediates Quorum Quenching in Pseudomonas Aeruginosa

Cite this Research Publication : Raja Biswas, Chatterjee, M., D'Morris, S., Baranwal, G., Warrier, S., Vasudevan, A., Muralidharan Vanuopadath, Nai, S., and Mohan, C., “Lactobacillus Fermentum Secreted Phenyl Lactic Acid Mediates Quorum Quenching in Pseudomonas Aeruginosa”, 2016.

Publisher : (2016)

Year : 2016

Post-translational Modifications of Proteins: Biomarkers and Therapeutic Targets for Diabetes Related Complications

Cite this Research Publication : Muralidharan Vanuopadath, Divya Nair, Dr. Bipin G. Nair, and Sudarslal Sadasivan Nair, “Post-translational Modifications of Proteins: Biomarkers and Therapeutic Targets for Diabetes Related Complications”, Current Proteomics, vol. 13, no. 4, pp. 251-270, 2016

Publisher : Current Proteomics.

Year : 2015

Strategy to Enhance Efficacy of Doxorubicin in Solid Tumor Cells by Methyl-β-cyclodextrin: Involvement of p53 and Fas Receptor Ligand Complex

Cite this Research Publication : Naoshad Mohammad, Shivendra Vikram Singh, Parmanand Malvi, Balkrishna Chaube, Dipti Athavale, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Dr. Bipin G. Nair, and Manoj Kumar Bhat, “Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complex”, Scientific reports, vol. 5, 2015

Publisher : Scientific reports

Conference Proceedings

Year : 2018

Proteomics investigation of complex venom toxin arsenal of Hypnale hypnale from the Western Ghats of India

Cite this Research Publication : Muralidharan Vanuopadath, Dileepkumar Raveendran, Bipin Gopalakrishnan Nair, Sudarslal Sadasivan Nair, Proteomics investigation of complex venom toxin arsenal of Hypnale hypnale from the Western Ghats of India, 10th annual meeting of proteomics society of India-International conference on proteomics for cell biology and molecular medicine, NCCS, Pune, India, December 12-14, 2018.

Year : 2017

Proteomic investigation of Trimeresurus malabaricus venom and its comparative functional analysis using Daboia Russelii venom, SnakeSymp-Snake venom research and snakebite therapy

Cite this Research Publication : Muralidharan Vanuopadath, Aswathy Alangode, Karthika Rajan, Nithin Sajeev, Dileepkumar Raveendran, Martein Reick, Margaret Reick, Bipin Gopalakrishnan Nair, Sudarslal Sadasivan Nair, Proteomic investigation of Trimeresurus malabaricus venom and its comparative functional analysis using Daboia Russelii venom, SnakeSymp-Snake venom research and snakebite therapy, Centre for Cellular and Molecular Biology, Hyderabad, India, December 1-3, 2017.

Year : 2017

Mass spectrometry-based quantitation of oxidized and reduced glutathione under diabetes-induced oxidative stress conditions

Cite this Research Publication : Muralidharan Vanuopadath, Bipin Gopalakrishnan Nair, Sudarslal Sadasivan Nair, Mass spectrometry-based quantitation of oxidized and reduced glutathione under diabetes-induced oxidative stress conditions, 27th Swadeshi Science Congress, Swadeshi Science Movement-Kerala, India, November 7-9, 2017.

Year : 2014

Isolation and Characterisation of Lipopeptides from a Bacillus subtilis sp. Strain, a marime algal endophyte

Cite this Research Publication : Divya Nair, Muralidharan Vanuopadath, Dr. Bipin G. Nair, Jayashree G, and Sudarslal S, “Isolation and Characterisation of Lipopeptides from a Bacillus subtilis sp. Strain, a marime algal endophyte”, Fourth International Seminar on Sustainable Utilisation of Tropical Plant Biomass- Ayur informatics. pp. 89-91, 2014.

Publisher : Fourth International Seminar on Sustainable Utilisation of Tropical Plant Biomass- Ayur informatics

Awards & Recognition
  • 2022: ICMR-DHR Young Scientist Fellowship from the Department of Health Research, Indian Council of Medical Research, Ministry of Health & Family Welfare, Government of India
  • 2022: Best Scientist’s paper presentation award- at the 34h Kerala Science Congress, Kerala State Council for Science, Technology & Environment and Kerala Government, Thiruvananthapuram
  • 2021: “Chancellors’ Publication Award” under Amrita Innovation and Research Awards (AIRA), from Amrita Vishwa Vidyapeetham
  • 2018: “Best Poster Award” at National Seminar on “Snake Venom Research and Snakebite Therapy” held at Centre for Cellular and Molecular Biology, Hyderabad, India, from December 1-3, 2017.
  • 2013: “Junior Research Fellowship” from Amrita Vishwa Vidyapeetham
  • 2012: GATE –Biotechnology

Invited Reviewer for International Journals: Mass Spectrometry Reviews, Analytical Chemistry

Teaching
  • 19BIO103: Intelligence of Biological Systems- B.Tech. Computer Science and Engineering (Artificial Intelligence)- First semester.
  • BIO317: Research Methodology- BSc. Biotechnology and BSc. Microbiology -Fifth Semester
  • 21BIO103: Intelligence of Biological Systems- B.Tech. Computer Science and Engineering (Artificial Intelligence)- First semester.
  • BIO319: Pharmacology-BSc. Biotechnology and BSc. Microbiology -Sixth Semester
Invited Talks
  • Proteomics of Hypnale hypnale Venom from The Western Ghats of India and Identification of Species-specific Sequences Through De novo Strategies- 3rd North American Mass Spectrometry Summer School, National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, US, June 2021.
Trainings and Workshops
  • Two month operator’s training course for Agilent LC/MS: Agilent OpenLAB Chemstation, Agilent 1290 uHPLC, Agilent 6340 LC/MS Iontrap, Agilent 8354 UV-Visible Spectrometer, held at the Amrita Agilent Analytical Research Centre, Amrita School of Biotechnology from 5th August – 5th October,2013 headed by Dr.Walter Schrenk, Associate Professor, Amrita School of Biotechnology.
  • Development of Analytical methods in High Performance Chromatography, uHPLC, 2-Dimensional HPLC and Mass Spectrometry for the analysis, isolation and identification of active components out of plant extracts with potential medical uses under the guidance of Dr. Walter Schrenk and Dr.Sudarslal S, the Associate Professors at Amrita School of Biotechnology, from January to May 2014.
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