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Course Detail

Course Name Drug Delivery, Pharmacokinetics & Pharmacodynamics
Course Code 25NBT513
Program M. Sc. Nanobiotechnology (NBT)
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

Fundamental concepts of drug delivery: Physicochemical Properties of Drugs, Effects of fundamental physicochemical properties on the biopharmaceutical behavior of drugs, Concentration-time curve of pharmacokinetics; Fundamentals of controlled drug delivery, Pharmacokinetic and pharmacodynamic basis of controlled drug delivery, Physicochemical and biological factors influencing design and performance of controlled release products.

Unit 2

Routes of Drug Delivery: Enteral – Oral, Sublingual, Buccal, Rectal; Parenteral – Intravenous, Intramuscular, Intra-arterial, Intra-thecal, Intradermal; Topical – Transdermal, Intranasal, Conjuctival; Conventional drug delivery systems; Concept of active and passive targeting of drugs

Unit 3

Introduction to pharmacokinetics; Route of administration of drugs; Pharmacokinetic Parameters – bioavailability, biological Half-life, volume of distribution and clearance; Absorption of drugs; Mechanism of drug absorption; Factors affecting drug absorption; Distribution of drugs; Protein binding of drugs; Factors affecting distribution of drugs; Metabolism of drugs; Excretion of drugs; Kinetic models

Unit 4

Introduction to pharmacodynamics, drug-receptor interaction, body compartment systems, Drug Action – Action and effect, Excitation and Inhibition, Selectivity of drug action, Therapeutic effect and adverse reaction, Principles of Drug action- Dose effect relationship, Time effect relationship, structure activity relationship, Mechanism of drug action- Simple physical and chemical property, involving or interfering physiological and biochemical process of living system.

Objectives and Outcomes

Pre-requisites: Basic level biology and biochemistry

Total number of classes: 45

COURSE OBJECTIVES

  • Be able to articulate the drug-intrinsic and extrinsic factors that determine drug molecule movement across biological membranes
  • To demonstrate understanding in concepts that determine dosage, absorption, distribution, and excretions of drugs, along with model systems connected with these concepts and apply pharmacokinetic principles to explain variation in drug disposition
  • To understand the basic concepts of drug delivery and physiochemical properties of the drug
  • To demonstrate understanding of different routes of drug administration and different drug delivery systems.
  • To understand basics of pharmacodynamics.

Course Outcome

CO1: Explain how physicochemical properties of drugs and nanocarriers influence biopharmaceutical behavior, controlled release, and pharmacokinetic profiles.

CO2: Compare and evaluate various routes of drug delivery-including nano-enabled systems-highlighting the principles of active and passive targeting and the advantages of nanotechnology in overcoming biological barriers.

CO3: Analyze pharmacokinetic parameters (bioavailability, half-life, volume of distribution, clearance) in the context of both conventional and nanotechnology-based drug delivery, and apply kinetic models to predict drug/nanocarrier disposition.

CO4: Describe the mechanisms of drug and nanocarrier absorption, distribution, metabolism, and excretion, emphasizing the role of nano-bio interactions and factors affecting these processes.

CO5: Interpret drug-receptor and nanoparticle-cell interactions, dose-response relationships, and structure-activity relationships, including the therapeutic and adverse effects unique to nanomedicine.

CO6: Critically assess the design and performance of controlled and targeted drug delivery systems, integrating nanoscience principles for improved therapeutic outcomes.

Programme Outcomes (PO) (As given by NBA and ABET)

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

CO-PO MAPPING:

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

CO1

3

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CO2

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2

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CO3

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3

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CO5

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PROGRAM SPECIFIC OUTCOMES (PSO):

PSO1: Mastery of Nanomaterial Science and Characterization

PSO2: Understanding of Cellular and Molecular Systems

PSO3: Application of Nanobiotech in Diagnostics and Therapy

PSO4: Experimental Design and Data Analysis

PSO5: Research Competency and Methodological Rigor

PSO6: Industry and Career Readiness

CO-PSO MAPPING:

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

CO1

3

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2

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CO2

3

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CO3

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1

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CO5

1

1

1

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1

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Text Books / References

TEXT BOOKS / REFERENCES:

  1. Robert E. Notari; Biopharmaceutics and Clinical Pharmacokinetics: An Introduction, Fourth Edition, 2017
  2. Leon Shargel, Susanna Wu-Pong, Andrew Yu; Applied Biopharmaceutics & Pharmacokinetics 5th edition, McGraw-Hill Medical 2004
  3. Rowland and Tozer, Clinical Pharmacokinetics: Concepts and Applications, 1995.
  4. Drug Delivery: Fundamentals and Applications, Second Edition, CRC Press 2017.
  5. Drug Delivery Systems, Pieter Stroeve and Morteza Mahmoudi, World Scientific Series: From Biomaterials towards Medical Devices, Vol I, 2018.
  6. Rosenbaum SE, editor. Basic pharmacokinetics and pharmacodynamics: An integrated textbook and computer simulations. John Wiley & Sons; 2016.

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