Year : 2023
Translational Phytomedicines against Cancer: Promise and Hurdles
Cite this Research Publication : Aswathy R Devan, Bhagyalakshmi Nair, Lekshmi.R. Nath, "Translational Phytomedicines against Cancer: Promise and Hurdles," Advanced Pharmaceutical Bulletin, 2023;13(2): 210-215. doi: 10.34172/apb.2023.023
Year : 2023
Green synthesized nanoparticles as a plausible therapeutic strategy against Hepatocellular Carcinoma: An update on its preclinical and clinical relevance
Cite this Research Publication : Chandrababu G, Sah SK, Kumar AR, M S, Nath LR. Green Synthesized Nanoparticles as a Plausible Therapeutic Strategy Against Hepatocellular Carcinoma: An Update on its Preclinical and Clinical Relevance. Recent Patents in Anticancer Drug Discovery. 2023;18(3):268-291. doi: 10.2174/1574892817666220523124437. PMID: 35616675.
Year : 2023
Tumor-Specific Growth Factor (TSGF): A futuristic Tumor Biomarker in Early Diagnosis of Cancer
Cite this Research Publication : Bhagyalakshmi Nair, Anisha Kuriakose, Bilha Baby, Lekshmi R. Nath, "Tumor-Specific Growth Factor (TSGF): A futuristic Tumor Biomarker in Early Diagnosis of Cancer,"Advanced Pharmaceutical Bulletin, 2023, doi: 10.34172/apb.2023.051
Year : 2023
Identification of Kaempferol as Viral Entry Inhibitor and DL-Arginine as Viral Replication Inhibitor from Selected Plants of Indian Traditional Medicine against COVID-19: An in silico Guided in vitro Approach.
Cite this Research Publication : J A, Murali M, Nair B, Benny F, P M R, Suresh D, P AT, Nisthul A, Nath LR. Identification of Kaempferol as viral entry inhibitor and DL-Arginine as viral replication inhibitor from selected plants of Indian traditional medicine against COVID-19: An in silico guided in vitro approach. Curr Comput Aided Drug Des. 2023 Jan 12. doi: 10.2174/1573409919666230112123213. Epub ahead of print. PMID: 36635906.
Year : 2023
Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo
Cite this Research Publication : Chandrababu G, Varkey M, Devan AR, Anjaly MV, Unni AR, Nath LR. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2023 Mar 29. doi: 10.1007/s00210-023-02468-8. Epub ahead of print. PMID: 36988659.
Year : 2022
Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma
Cite this Research Publication : Kumar AR, Devan AR, Nair B, Nair RR, Nath LR. "Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma." Current Cancer Drug Targets. 2022;22(9):725-740. doi: 10.2174/1568009622666220317090552. PMID: 35301949.
Year : 2022
Decoding the mechanism of drugs of heterocyclic nature against hepatocellular carcinoma
Cite this Research Publication : Kumar AR, L A, Nair B, Mathew B, Sugunan S, Nath LR. Decoding the mechanism of drugs of heterocyclic nature against hepatocellular carcinoma. Anti-Cancer Agents in Medicinal Chemistry. 2022 Apr 18. doi: 10.2174/1871520622666220418115310. Epub ahead of print. PMID: 35440316.
Year : 2022
Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma
Cite this Research Publication : Devan AR, Pavithran K, Nair B, Murali M, Nath LR. Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma. World Journal of Gastroenterology. 2022 Sep 28;28(36):5250-5264. doi: 10.3748/wjg.v28.i36.5250. PMID: 36185626; PMCID: PMC9521521.
Year : 2022
Evaluation of the active constituents of Nilavembu Kudineer for viral replication inhibition against SARS‐CoV‐2: An approach to targeting RNA‐dependent RNA polymerase (RdRp)
Cite this Research Publication : Kuriakose A, Nair B, Abdelgawad MA, Adewum AT, Soliman MES, Mathew B, Nath LR. Evaluation of the active constituents of Nilavembu Kudineer for viral replication inhibition against SARS-CoV-2: An approach to targeting RNA-dependent RNA polymerase (RdRp). Journal of Food Biochemistry. 2022 Nov;46(11):e14367. doi: 10.1111/jfbc.14367. Epub 2022 Aug 22. PMID: 35994404; PMCID: PMC9539176.
Year : 2022
Evaluation of the Nimbamrithadhi Panchathiktha Kashayam against SARS CoV-2 based on Network Pharmacology and Molecular Docking analysis
Cite this Research Publication : Murali M, Nair B, Radhakrishnan VV, Presanna AT, Nath LR. Evaluation of the Nimbamrithadhi Panchathiktha Kashayam against SARS CoV-2 based on Network Pharmacology and Molecular Docking analysis. Combinatorial Chemistry and High Throughput Screening. 2023;26(2):436-447. doi: 10.2174/1386207325666220519112846. PMID: 35598237.
Year : 2022
2,4-Dihydroxycinnamic acid as spike ACE2 inhibitor and apigenin as RdRp inhibitor in Nimbamritadi Panchatiktam Kashayam against COVID-19: an in silico and in vitro approach
Cite this Research Publication : Murali M, Nair B, Vishnu VR, Aneesh TP, Nath LR. 2,4-Dihydroxycinnamic acid as spike ACE2 inhibitor and apigenin as RdRp inhibitor in Nimbamritadi Panchatiktam Kashayam against COVID-19: an in silico and in vitro approach. Molecular Diversity. 2022 Nov 10:1–11. doi: 10.1007/s11030-022-10552-z. Epub ahead of print. PMID: 36357813; PMCID: PMC9648999.
Year : 2022
Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma
Cite this Research Publication : Nath LR, Swetha M, Vijayakurup V, Thangarasu AK, Haritha NH, Shabna A, Aiswarya SU, Rayginia TP, Keerthana CK, Kalimuthu K, Sundaram S, Lankalapalli RS, Pillai S, Towner R, Isakov N, Anto RJ. Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma. Frontiers in oncology. 2022 Feb 8;12:812598. doi: 10.3389/fonc.2022.812598. Erratum in: Frontiers in oncology, 2022 Aug 25;12:991401. PMID: 35211405; PMCID: PMC8861526.
Year : 2021
Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions
Cite this Research Publication : Mathew, B., Oh, J.M., Khames, A., Mathew, G.E., Kim, H. Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions, Pharmaceuticals, 2021, 14(11),1148, DOI: 10.3390/ph14111148
Publisher : Pharmaceuticals
Year : 2021
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy: A Concise Treatise
Publisher : Current Molecular Medicine
Year : 2021
An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease
Publisher : Biotechnology and Applied Biochemistry
Year : 2021
Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
Publisher : ACS omega.
Year : 2021
Ameliorative effect of ethoxylatedchalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson’s diseases
Publisher : Environmental Science and Pollution Research.
Year : 2021
Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review
Publisher : Journal of Food Biochemistry
Year : 2021
Mucus targeting as a plausible approach to improve lung function in covid-19 patients
Publisher : Medical Hypotheses.
Year : 2021
Antibody–drug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance
Publisher : Clinical and Translational Oncology
Year : 2021
Critical biomarkers of hepatocellular carcinoma in body fluids and gut microbiota
Cite this Research Publication : Nath LR, Murali M, Nair B. Critical biomarkers of hepatocellular carcinoma in body fluids and gut microbiota. World Journal of Gastrointestinal Oncology. 2021 Dec 15;13(12):2219-2222. doi: 10.4251/wjgo.v13.i12.2219. PMID: 35070054; PMCID: PMC8713307.
Year : 2021
Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets
Cite this Research Publication : Kumar AR, Devan AR, Nair B, Vinod BS, Nath LR. Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets. Mol Biol Rep. 2021 Dec;48(12):8075-8095. doi: 10.1007/s11033-021-06752-9. Epub 2021 Oct 20. PMID: 34671902; PMCID: PMC8605995.
Publisher : Molecular Biology Reports
Year : 2021
The Impetus of COVID -19 in Multiple Organ Affliction apart from Respiratory Infection
Cite this Research Publication : Bilha Baby, Aswathy R. Devan, Bhagyalakshmi Nair, and Lekshmi R Nath, “The Impetus of COVID -19 in Multiple Organ Affliction apart from Respiratory Infection”, Pathogenesis, Diagnostic Measures and Current Treatment Strategy, Infectious Disorders-Drug targets, 2021, 21(4), pp. 514-526.
Publisher : Infectious Disorders-Drug targets
Year : 2021
Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma
Cite this Research Publication : Devan AR, Kumar AR, Nair B, Anto NP, Muraleedharan A, Bijo Mathew, Kim H, and Nath LR, “Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma”, Pharmaceuticals, vol. 14, no. 7, p. 656, 2021.
Publisher : Pharmaceuticals
Year : 2021
Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.
Cite this Research Publication : P. Koyiparamb Vishal, Oh, J. Min, Khames, A., Abdelgawad, M. A., Nair, A. Sujathan, Nath, L. R., Gambacorta, N., Ciriaco, F., Nicolotti, O., Kim, H., and Bijo Mathew, “Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.”, Pharmaceutics, vol. 13, no. 6, 2021.
Publisher : Pharmaceutics
Year : 2021
Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.
Cite this Research Publication : Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R. Kumar, Jaggaiah N. Gorantla, Aishwarya T. S., and Lekshmi R Nath, “Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.”, Curr Pharm Biotechnol, 2021.
Publisher : Curr Pharm Biotechnol
Year : 2021
Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment.
Cite this Research Publication : Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, and Lekshmi R Nath, “Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment.”, Current drug targets, 2021, 22(11), pp. 1288-1316
Publisher : Curr Drug Targets
Year : 2021
An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease.
Cite this Research Publication : Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R. Kumar, and Lekshmi R Nath, “An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease.”, Biotechnology and Applied Biochemistry, 2021.
Publisher : Biotechnology and Applied Biochemistry (Article in Press)
Year : 2021
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.
Cite this Research Publication : Sherin Joseph, Bhagyalakshmi Nair, and Lekshmi R Nath, “The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.”, Curr Mol Med, 2021.
Publisher : Current Molecular Medicine
Year : 2021
MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy.
Cite this Research Publication : Chameli Ratan, Dixon Dalia Cici Kattiparambil, Bhagyalakshmi Nair, and Lekshmi R Nath, “MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy.”, Current Cancer Drug Targets, 2021, 21(2), pp. 132-152
Publisher : Current cancer drug targets
Year : 2021
RNA sensors as a mechanism of innate immune evasion among SARS-CoV2, HIV and Nipah viruses.
Cite this Research Publication : Dixon Dalia Cici Kattiparambil, Chameli Rata, Bhagyalakshmi Nair, Sabitha Mangalath, Rachy Abraham, and Lekshmi R Nath, “RNA sensors as a mechanism of innate immune evasion among SARS-CoV2, HIV and Nipah viruses.”, Curr Protein Pept Sci, 2021.
Publisher : Curr Protein Pept Sci
Year : 2021
Curry Versus Cancer: Potential of Some Selected Culinary Spices Against Cancer with in vitro, in Vivo, and Human Trials Evidences
Cite this Research Publication : A. J. Kammath, Nair, B., P, S., and Lekshmi R Nath, “Curry Versus Cancer: Potential of Some Selected Culinary Spices Against Cancer with in vitro, in Vivo, and Human Trials Evidences”, Journal of Food Biochemistry Special issue – Pharma Food, 2021, 45(3),e13285
Publisher : Journal of Food Biochemistry Special issue – Pharma Food
Year : 2021
The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review
Cite this Research Publication : Adithya J., Bhagyalakshmi Nair, Aishwarya S., and Lekshmi R Nath, “The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review”, Current Pharmaceutical Biotechnology, 2021, 22(7), pp. 906-919
Publisher : Current Pharmaceutical Biotechnology
Year : 2020
Inevitable role of TGF-β1 in the progression of nonalcoholic fatty liver disease
Publisher : Journal of Receptors and Signal Transduction.
Year : 2020
The Impetus of COVID-19 in Multiple Organ Affliction apart from Res-piratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy
Publisher : Infectious Disorders Drug Targets.
Year : 2020
Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: an In silico Approach
Cite this Research Publication : Siniprasad P, Nair B, Balasubramaniam V, Sadanandan, Prashant, Namboori P K, Nath L R. Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach. Letters in Drug Design & Discovery, 2020, 17 (11), 1401-1408. doi: 10.2174/1570180817999200623115703
Publisher : Letters in Drug Design & Discovery
Year : 2020
The Impetus of COVID -19 in Multiple Organ Affliction Apart from Respiratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy
Cite this Research Publication : B. Baby, Aswathy R. Devan, and Nath*, B. Nair and L., “The Impetus of COVID -19 in Multiple Organ Affliction Apart from Respiratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy”, Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders), vol. 20. pp. 1-13, 2020.
Publisher : Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)
Year : 2020
Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An in Silico and in Vitro Approach
Cite this Research Publication : B. Nair, Anto, R. John, Dr. Sabitha M., and Lekshmi R Nath, “Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An in Silico and in Vitro Approach”, Adv Pharm Bull, vol. 10, no. 3, pp. 472-476, 2020.
Publisher : Adv Pharm Bull, Tabriz University of Medical Sciences
Year : 2016
In vitro and in vivo evaluation of the anticancer potential of SN2, a spirostan-3-ol derivative identified and characterized from Solanum nigrum Linn against hepatocellular carcinoma
Publisher : Proceedings of 28th Kerala Science Congress
Year : 2016
In Vitro Evaluation of the Antioxidant, 3, 5-Dihydroxy-4-ethyl-trans-stilbene (DETS) Isolated from Bacillus cereus as a Potent Candidate against Malignant Melanoma
Publisher : Frontiers in microbiology.
Year : 2016
In Vitro Evaluation of the Antioxidant, 3,5-Dihydroxy-4-Ethyl-Trans-Stilbene (DETS) Isolated from Bacillus Cereus as a Potent Candidate Against Malignant Melanoma
Cite this Research Publication : Lekshmi R Nath, Kumar, S. N., Das, A. A., Nambisan, B., Shabna, C. Mohandas, and Anto, R. J., “In Vitro Evaluation of the Antioxidant, 3,5-Dihydroxy-4-Ethyl-Trans-Stilbene (DETS) Isolated from Bacillus Cereus as a Potent Candidate Against Malignant Melanoma”, Frontiers in Microbiology, vol. 7, no. 452, 2016
Publisher : Frontiers in Microbiology .
Year : 2016
Evaluation of Uttroside B, a Saponin from Solanum Nigrum Linn, as a Promising Chemotherapeutic Agent Against Hepatocellular Carcinoma
Cite this Research Publication : Lekshmi R Nath, Gorantla, J. N., Thulasidasan, A. T., Vijayakurup, V., Shah, S., Anwer, S., Joseph, S. M., Antony, J., Veena, K. Suresh, Sundaram, S., Marelli, U. K., Lankalapalli, R. S., and Anto, R. John, “Evaluation of Uttroside B, a Saponin from Solanum Nigrum Linn, as a Promising Chemotherapeutic Agent Against Hepatocellular Carcinoma”, Sci. Rep. 2016, vol. 6, 2016
Publisher : Sci. Rep. 2016 .
Year : 2015
DW-F5: A Novel Formulation Against Malignant Melanoma from Wrightia Tinctoria
Cite this Research Publication : J. Antony, Saikia, M., .V, V., Lekshmi R Nath, Katiki, M. Rao, Murty, M. S. R., Paul, A., A, S., Chandran, H., Joseph, S. Margaret, S, N. Kumar., Panakkal, E. Jayex, I.V, S., I.V, S., Ran, S., S, S., Rajan, E., and Anto, R. John, “DW-F5: A Novel Formulation Against Malignant Melanoma from Wrightia Tinctoria”, Scientific Reports, 2015
Publisher : Scientific Reports
Year : 2015
Kaempferide, the Most Active Among the Four Flavonoids Isolated and Characterized from Chromolaena Odorata, Induces Apoptosis in Cervical Cancer Cells While Being Pharmacologically Safe
Cite this Research Publication : Lekshmi R Nath, Gorantla, J. N., Joseph, S. Margaret, Antony, J., Thankachan, S., Menon, D. B., S. Sankar, Lankalapalli, R. S., and Anto, R. John, “Kaempferide, the Most Active Among the Four Flavonoids Isolated and Characterized from Chromolaena Odorata, Induces Apoptosis in Cervical Cancer Cells While Being Pharmacologically Safe”, RSC Advances, vol. 5, pp. 100912-100922, 2015
Publisher : RSC Advances
Year : 2014
Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of ‘suicide tree’Cerberaodollam
Publisher : Natural product research.
Year : 2014
Synthesis of salicylic acid-based 1, 3, 4-oxadiazole derivatives coupled with chiral oxazolidinones: Novel hybrid heterocycles as antitumor agents
Publisher : Letters in Drug Design & Discovery
Year : 2014
[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling
Cite this Research Publication : R. E. K, Bava, S. V., Narayanan, S. Shyam, Lekshmi R Nath, Thulasidasan, A. Kumar, V, S. E., and Anto, R. John, “[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling”, PLOS ONE, vol. 9, no. 8, 2014
Publisher : PLOS ONE
Year : 2013
Synthesis of piperazinylbenzothiazole/benzoxazole derivatives coupled with 1, 3, 4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents
Publisher : Medicinal Chemistry Research.
Year : 2010
General approaches towards extraction of medicinal plants
Publisher : Amala Research Bulletin
Year : 2010
Anti-inflammatory activity of Mirabilis jalapa linn. Leaves
Cite this Research Publication : Lekshmi R Nath, KP, M., RV, S., and KS, A., “Anti-inflammatory activity of Mirabilis jalapa linn. Leaves”, J Basic Clin Pharm, vol. 1, no. 2, 2010
Publisher : J Basic Clin Pharm
Year : 2009
Pharmacognostical and Phytochemical Studies of Mirabilis jalapa Linn. leaves
Cite this Research Publication : Lekshmi R Nath, KP, M., RV, S., and K.S, A., “Pharmacognostical and Phytochemical Studies of Mirabilis jalapa Linn. leaves”, Pharmacognosy Journal, vol. 1, no. 2, pp. 111 - 115, 2009
Publisher : Pharmacognosy Journal