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Dr. Lekshmi R. Nath

Asst. Professor, Pharmacognosy, School of Pharmacy, Kochi

Qualification: M. Pharm., Ph.D
lekshmirnath@aims.amrita.edu
Research Interest: Bioprospecting of Anticancer Compounds, Cell Death Mechanism, Chemoprevention, Chemotherapy, Hepatocellular Carcinoma

Bio

Dr. Lekshmi R. Nath joined as Assistant Professor in the Department of Pharmacognosy at Amrita School of Pharmacy in January 2018. She pursued her Ph.D. under Dr. Ruby John Anto, Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Trivandrum, Kerala, an autonomous Research Institution under DBT, Govt: of India. Her Ph.D. findings on hepatocellular carcinoma recently received four international patents US, Canada, Japan & South Korea (WO 2017208254 A1, “Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma”). The USFDA has recently granted an orphan drug designation to the small molecule chemotherapeutic Uttroside–B against hepatocellular carcinoma. MOU signed by RGCB with Oklahoma Medical Research Foundation, USA for the clinical translation of Uttroside B in liver cancer patients and technology transfer carried out for the same with a multi-national company, Q Biomed.

Dr. Lekshmi completed her M.Pharm from KLE University’s College of Pharmacy, Karnataka and B.Pharm from Dept. of Pharmaceutical Sciences, Cheruvandoor Campus, Kottayam. She has more than 9 year’s research experience at the Division of Cancer Research, RGCB. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemosensitization as well as in chemotherapy. She is also exploring the potential of traditional knowledge for various infectious diseases, their mechanism of action and validation through pre-clinical models.

Publications

Journal Article

Year : 2021

The Impetus of COVID -19 in Multiple Organ Affliction apart from Respiratory Infection

Cite this Research Publication : Bilha Baby, Aswathy R. Devan, Bhagyalakshmi Nair, and Lekshmi R Nath, “The Impetus of COVID -19 in Multiple Organ Affliction apart from Respiratory Infection”, Pathogenesis, Diagnostic Measures and Current Treatment Strategy, Infectious Disorders-Drug targets, 2021, 21(4), pp. 514-526.

Publisher : Infectious Disorders-Drug targets

Year : 2021

Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.

Cite this Research Publication : Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R. Kumar, Jaggaiah N. Gorantla, Aishwarya T. S., and Lekshmi R Nath, “Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.”, Curr Pharm Biotechnol, 2021.

Publisher : Curr Pharm Biotechnol

Year : 2021

Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment.

Cite this Research Publication : Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, and Lekshmi R Nath, “Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment.”, Current drug targets, 2021, 22(11), pp. 1288-1316

Publisher : Curr Drug Targets

Year : 2021

The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.

Cite this Research Publication : Sherin Joseph, Bhagyalakshmi Nair, and Lekshmi R Nath, “The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.”, Curr Mol Med, 2021.

Publisher : Current Molecular Medicine

Year : 2021

MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy.

Cite this Research Publication : Chameli Ratan, Dixon Dalia Cici Kattiparambil, Bhagyalakshmi Nair, and Lekshmi R Nath, “MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy.”, Current Cancer Drug Targets, 2021, 21(2), pp. 132-152

Publisher : Current cancer drug targets

Year : 2021

An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease.

Cite this Research Publication : Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R. Kumar, and Lekshmi R Nath, “An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease.”, Biotechnology and Applied Biochemistry, 2021.

Publisher : Biotechnology and Applied Biochemistry (Article in Press)

Year : 2021

RNA sensors as a mechanism of innate immune evasion among SARS-CoV2, HIV and Nipah viruses.

Cite this Research Publication : Dixon Dalia Cici Kattiparambil, Chameli Rata, Bhagyalakshmi Nair, Sabitha Mangalath, Rachy Abraham, and Lekshmi R Nath, “RNA sensors as a mechanism of innate immune evasion among SARS-CoV2, HIV and Nipah viruses.”, Curr Protein Pept Sci, 2021.

Publisher : Curr Protein Pept Sci

Year : 2021

Curry Versus Cancer: Potential of Some Selected Culinary Spices Against Cancer with in vitro, in Vivo, and Human Trials Evidences

Cite this Research Publication : A. J. Kammath, Nair, B., P, S., and Lekshmi R Nath, “Curry Versus Cancer: Potential of Some Selected Culinary Spices Against Cancer with in vitro, in Vivo, and Human Trials Evidences”, Journal of Food Biochemistry Special issue – Pharma Food, 2021, 45(3),e13285

Publisher : Journal of Food Biochemistry Special issue – Pharma Food

Year : 2021

The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review

Cite this Research Publication : Adithya J., Bhagyalakshmi Nair, Aishwarya S., and Lekshmi R Nath, “The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review”, Current Pharmaceutical Biotechnology, 2021, 22(7), pp. 906-919

Publisher : Current Pharmaceutical Biotechnology

Year : 2020

The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review.

Cite this Research Publication : Adithya J., Bhagyalakshmi Nair, Aishwarya S., and Lekshmi R Nath, “The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review.”, Curr Pharm Biotechnol, 2020.

Publisher : Curr Pharm Biotechnol

Year : 2020

Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: an In silico Approach

Cite this Research Publication : P. Siniprasad, Nair, B., Balasubramaniam, V., Sadanandan, P., Namboori, P. Krishnan K., and Lekshmi R Nath, “Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: an In silico Approach”, Letters in Drug Design & Discovery, 2020

Publisher : Letters in Drug Design & Discovery

Year : 2020

The Impetus of COVID -19 in Multiple Organ Affliction Apart from Respiratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy

Cite this Research Publication : B. Baby, Aswathy R. Devan, and Nath*, B. Nair and L., “The Impetus of COVID -19 in Multiple Organ Affliction Apart from Respiratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy”, Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders), vol. 20. pp. 1-13, 2020.

Publisher : Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)

Year : 2016

In Vitro Evaluation of the Antioxidant, 3,5-Dihydroxy-4-Ethyl-Trans-Stilbene (DETS) Isolated from Bacillus Cereus as a Potent Candidate Against Malignant Melanoma

Cite this Research Publication : Lekshmi R Nath, Kumar, S. N., Das, A. A., Nambisan, B., Shabna, C. Mohandas, and Anto, R. J., “In Vitro Evaluation of the Antioxidant, 3,5-Dihydroxy-4-Ethyl-Trans-Stilbene (DETS) Isolated from Bacillus Cereus as a Potent Candidate Against Malignant Melanoma”, Frontiers in Microbiology, vol. 7, no. 452, 2016

Publisher : Frontiers in Microbiology .

Year : 2016

Evaluation of Uttroside B, a Saponin from Solanum Nigrum Linn, as a Promising Chemotherapeutic Agent Against Hepatocellular Carcinoma

Cite this Research Publication : Lekshmi R Nath, Gorantla, J. N., Thulasidasan, A. T., Vijayakurup, V., Shah, S., Anwer, S., Joseph, S. M., Antony, J., Veena, K. Suresh, Sundaram, S., Marelli, U. K., Lankalapalli, R. S., and Anto, R. John, “Evaluation of Uttroside B, a Saponin from Solanum Nigrum Linn, as a Promising Chemotherapeutic Agent Against Hepatocellular Carcinoma”, Sci. Rep. 2016, vol. 6, 2016

Publisher : Sci. Rep. 2016 .

Year : 2015

DW-F5: A Novel Formulation Against Malignant Melanoma from Wrightia Tinctoria

Cite this Research Publication : J. Antony, Saikia, M., .V, V., Lekshmi R Nath, Katiki, M. Rao, Murty, M. S. R., Paul, A., A, S., Chandran, H., Joseph, S. Margaret, S, N. Kumar., Panakkal, E. Jayex, I.V, S., I.V, S., Ran, S., S, S., Rajan, E., and Anto, R. John, “DW-F5: A Novel Formulation Against Malignant Melanoma from Wrightia Tinctoria”, Scientific Reports, 2015

Publisher : Scientific Reports

Year : 2015

Kaempferide, the Most Active Among the Four Flavonoids Isolated and Characterized from Chromolaena Odorata, Induces Apoptosis in Cervical Cancer Cells While Being Pharmacologically Safe

Cite this Research Publication : Lekshmi R Nath, Gorantla, J. N., Joseph, S. Margaret, Antony, J., Thankachan, S., Menon, D. B., S. Sankar, Lankalapalli, R. S., and Anto, R. John, “Kaempferide, the Most Active Among the Four Flavonoids Isolated and Characterized from Chromolaena Odorata, Induces Apoptosis in Cervical Cancer Cells While Being Pharmacologically Safe”, RSC Advances, vol. 5, pp. 100912-100922, 2015

Publisher : RSC Advances

Year : 2014

[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling

Cite this Research Publication : R. E. K, Bava, S. V., Narayanan, S. Shyam, Lekshmi R Nath, Thulasidasan, A. Kumar, V, S. E., and Anto, R. John, “[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling”, PLOS ONE, vol. 9, no. 8, 2014

Publisher : PLOS ONE

Year : 2010

Anti-inflammatory activity of Mirabilis jalapa linn. Leaves

Cite this Research Publication : Lekshmi R Nath, KP, M., RV, S., and KS, A., “Anti-inflammatory activity of Mirabilis jalapa linn. Leaves”, J Basic Clin Pharm, vol. 1, no. 2, 2010

Publisher : J Basic Clin Pharm

Year : 2009

Pharmacognostical and Phytochemical Studies of Mirabilis jalapa Linn. leaves

Cite this Research Publication : Lekshmi R Nath, KP, M., RV, S., and K.S, A., “Pharmacognostical and Phytochemical Studies of Mirabilis jalapa Linn. leaves”, Pharmacognosy Journal, vol. 1, no. 2, pp. 111 - 115, 2009

Publisher : Pharmacognosy Journal

Patents

Year : 2016

Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma

Cite this Research Publication : Lekshmi R Nath and Anto, R. John, “Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma”, U.S. Patent 2016410184012016.

Publisher : Number 201641018401, India .

Patents
  • Ruby John Anto and Lekshmi R Nath, Uttroside B and derivatives thereof as therapeutics for hepatocellular carcinoma, Filed on 28 May 2016. Funding by Rajiv Gandhi Centre For Biotechnology.

Patent Application No. 201641018401

Current Status: PCT/IN2017/050204

WO2017208254A1

  • National Patent Application No. 201641018401 dated 28th May 2016
  • International patent Application No. PCT/ IN20 17/050204 dated 27th May 2017
  • Ph.D. findings on hepatocellular carcinoma recently received US, Canada, Japan & South Korea Patent (WO 2017208254 A1,Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma”.
  • USFDA has recently granted an orphan drug designation to the small molecule chemotherapeutic UttrosideB against hepatocellular carcinoma.

Technology transfer/commercialization

Transferred the technology to Q Biomed, USA. Patent royalty payment received.

Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma (PCT/ IN20 17/050204 dated 27th May 2017) (https://adisinsight.springer.com/drugs/800048876); https://qbiomed.com/index.php/pipeline/uttroside)

Research

Research Grant

Ongoing Projects

  • Amrita Vishwa Vidya Peetham Seed Grant 2021-2022
    Principal Investigator
    Liposomal drug delivery of phytochemical against Hepatocellular carcinoma
  • KSCSTE Project
    Principal Investigator
    Duration: January 2020 – January 2021
    Comparative evaluation of Kaempferol and its semisynthetic derivative as mTORC1 inhibitor against hepatocellular carcinoma: An in-vitro approach.
  • Amrita Vishwa Vidya Peetham Seed Grant 2018-19
    Principal Investigator
    Duration: April 2018 – May 2019
    Chemo sensitizing property of phytochemicals in improving the efficacy of marketed drugs for liver cancer.

Research Interest

  • Nutraceuticals and lifestyle disorders-Sustainable development goal 3
  • Phytomedicine and Cancer biology- Sustainable development goal 3
  • Hepatocellular Carcinoma- Chemoprevention and Chemotherapy
  • Biomarkers in Liver disorders
  • Non-alcoholic fatty liver disease (NAFLD)
  • Non-alcoholic steatohepatitis (NASH)
Achievements and Awards
  • Publication Grant Award  2022 for the Scopus indexed research paper from KSCSTE student project scheme.
  • Recipient of AIRA 2021 Publication Merit Award & Certificate of Appreciation for Research (Amrita Innovation and Research Awards to honour outstanding faculty, Amrita Vishwa Vidyapeetham).
  • Recipient of Bharat Vikas Award 2018from Institute of Self Reliance (ISR), the Press Club of Odisha, Bhubaneswar-1 on December 1, 2018, for the outstanding performance in the field of Cancer Chemoprevention.
  • WCP-NP Best Poster Presentation 2019at 5th IUPHAR World Conference on the Pharmacology of Natural products & 51st Annual Conference of Indian Pharmacological society held at ICMR, National Institute of Nutrition, Hyderabad, India on 5-7 December 2019.
  • Senior Research Fellowship(SRF) from Indian Council of Medical Research (ICMR) in February 2011
  • OMICS International Best Poster Awardat the 8th Euro biotechnology congress, Frankfurt Main, Germany, August 2015
  • Best paper Awardunder Biotechnologycategory for oral presentation at 28th Kerala Science Congress, University of Calicut Campus, Thenhipalam, Malappuram District, India, January 2016
  • Best Oral Presentation awardin the “International Conference on Neutraceuticals in Chronic Disease-2016 held at Kochi, Kerala, India, September 2016
  • Dr M.R. Das Career Awardin recognition of the Professional achievement during PhD tenure in RGCB, December 2016
  • Kerala State Council for Science, Technology and Environment(KSCTEC) Best Paper Award for Project “Mechanistic evaluation of the anti-tumour effect of SN2, the active principle of Solanum nigrum Linn in hepatocellular carcinoma, 2016 July-December 2017.
Membership
  • European association of cancer Research (Membership number: EACR26534)
Reviewer
  1. Natural Product Research, Taylor and Francis
  2. World Journal of Gastroenterology, Baishideng Publishing Group Inc
  3. MDPI journals( International Journal of Environmental Research and Public Health, Processes)
  4. Cellular and Molecular Biology Letters, BMC
  5. Annals of Medicine, Taylor and Francis
  6. Pharmaceutical Biology, Pharmaceutical Biology
  7. Expert Opinion on Pharmacotherapy, Expert Opinion on Pharmacotherapy
  8. World Journal of Pharmacology, Baishideng Publishing Group Inc
  9. Bioengineered, Taylor and Francis
  10. World Journal of Clinical cases, Baishideng Publishing Group Inc
  11. Chemistry & Biodiversity, Wiley
  12. Cell Transplantation
  13. ACS Pharmacology and Translational Medicine
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