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Dr. Lekshmi R. Nath

Associate Professor, Department of Pharmacognosy, Amrita School of Pharmacy, Kochi

Qualification: M. Pharm., Ph.D
lekshmirnath@aims.amrita.edu
ORCID ID
Google Scholar Profile
Scopus Author ID
Research Interest: Bioprospecting of Anticancer Compounds, Cell Death Mechanism, Chemoprevention, Chemotherapy, Hepatocellular Carcinoma

Bio

Dr. Lekshmi R. Nath is an Associate Professor in the Department of Pharmacognosy at the Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She completed her PhD under the guidance of Dr. Ruby John Anto in the Cancer Research Program at the Rajiv Gandhi Centre for Biotechnology (RGCB), Trivandrum, Kerala, an autonomous research institution under the Department of Biotechnology, Government of India. Her groundbreaking PhD research on hepatocellular carcinoma led to four international patents (US, Canada, Japan, and South Korea) for her work on “Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma” (WO 2017208254 A1). Notably, the USFDA has granted orphan drug designation to Uttroside B for its potential as a chemotherapeutic agent against hepatocellular carcinoma. In a significant advancement, RGCB has signed an MOU with the Oklahoma Medical Research Foundation, USA, to facilitate the clinical translation of Uttroside B for liver cancer patients. Additionally, technology transfer has been executed with the multinational company Q Biomed.

Dr. Lekshmi earned her M.Pharm from KLE University’s College of Pharmacy, Karnataka, and her B.Pharm from the Department of Pharmaceutical Sciences, Cheruvandoor Campus, Kottayam. With over nine years of research experience at the Division of Cancer Research, RGCB, she has made substantial contributions to the field of Phytomedicine and Liver Cancer. She recently edited a book entitled Liver Cancer and Phytomedicine: Chemoprevention, Chemosensitization, and Chemotherapy Strategies (World Scientific Publishing Co Pte Ltd, Singapore ).

She serves as a Guest Editor for Frontiers in Oncology (Pharmacology of Anti-Cancer Drugs) and Frontiers in Pharmacology (Ethnopharmacology). Her current research interests focus on the signalling events associated with the progression from fatty liver to hepatocellular carcinoma, the role of plant-derived compounds in Liver cancer chemoprevention, chemosensitization, and chemotherapy strategies. Additionally, she explores the potential of traditional knowledge in combating various liver disorders and infectious diseases concerning the aspects of immunotherapy, investigating their mechanisms of action, and validating them through pre-clinical models.

Publications

Journal Article

Year : 2023

Translational Phytomedicines against Cancer: Promise and Hurdles

Cite this Research Publication : Aswathy R Devan, Bhagyalakshmi Nair, Lekshmi.R. Nath, "Translational Phytomedicines against Cancer: Promise and Hurdles," Advanced Pharmaceutical Bulletin, 2023;13(2): 210-215. doi: 10.34172/apb.2023.023

Year : 2023

Green synthesized nanoparticles as a plausible therapeutic strategy against Hepatocellular Carcinoma: An update on its preclinical and clinical relevance

Cite this Research Publication : Chandrababu G, Sah SK, Kumar AR, M S, Nath LR. Green Synthesized Nanoparticles as a Plausible Therapeutic Strategy Against Hepatocellular Carcinoma: An Update on its Preclinical and Clinical Relevance. Recent Patents in Anticancer Drug Discovery. 2023;18(3):268-291. doi: 10.2174/1574892817666220523124437. PMID: 35616675.

Year : 2023

Tumor-Specific Growth Factor (TSGF): A futuristic Tumor Biomarker in Early Diagnosis of Cancer

Cite this Research Publication : Bhagyalakshmi Nair, Anisha Kuriakose, Bilha Baby, Lekshmi R. Nath, "Tumor-Specific Growth Factor (TSGF): A futuristic Tumor Biomarker in Early Diagnosis of Cancer,"Advanced Pharmaceutical Bulletin, 2023, doi: 10.34172/apb.2023.051

Year : 2023

Identification of Kaempferol as Viral Entry Inhibitor and DL-Arginine as Viral Replication Inhibitor from Selected Plants of Indian Traditional Medicine against COVID-19: An in silico Guided in vitro Approach.

Cite this Research Publication : J A, Murali M, Nair B, Benny F, P M R, Suresh D, P AT, Nisthul A, Nath LR. Identification of Kaempferol as viral entry inhibitor and DL-Arginine as viral replication inhibitor from selected plants of Indian traditional medicine against COVID-19: An in silico guided in vitro approach. Curr Comput Aided Drug Des. 2023 Jan 12. doi: 10.2174/1573409919666230112123213. Epub ahead of print. PMID: 36635906.

Year : 2023

Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo

Cite this Research Publication : Chandrababu G, Varkey M, Devan AR, Anjaly MV, Unni AR, Nath LR. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2023 Mar 29. doi: 10.1007/s00210-023-02468-8. Epub ahead of print. PMID: 36988659.

Year : 2022

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

Cite this Research Publication : Kumar AR, Devan AR, Nair B, Nair RR, Nath LR. "Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma." Current Cancer Drug Targets. 2022;22(9):725-740. doi: 10.2174/1568009622666220317090552. PMID: 35301949.

Year : 2022

Decoding the mechanism of drugs of heterocyclic nature against hepatocellular carcinoma

Cite this Research Publication : Kumar AR, L A, Nair B, Mathew B, Sugunan S, Nath LR. Decoding the mechanism of drugs of heterocyclic nature against hepatocellular carcinoma. Anti-Cancer Agents in Medicinal Chemistry. 2022 Apr 18. doi: 10.2174/1871520622666220418115310. Epub ahead of print. PMID: 35440316.

Year : 2022

Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma

Cite this Research Publication : Devan AR, Pavithran K, Nair B, Murali M, Nath LR. Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma. World Journal of Gastroenterology. 2022 Sep 28;28(36):5250-5264. doi: 10.3748/wjg.v28.i36.5250. PMID: 36185626; PMCID: PMC9521521.

Year : 2022

Evaluation of the Nimbamrithadhi Panchathiktha Kashayam against SARS CoV-2 based on Network Pharmacology and Molecular Docking analysis

Cite this Research Publication : Murali M, Nair B, Radhakrishnan VV, Presanna AT, Nath LR. Evaluation of the Nimbamrithadhi Panchathiktha Kashayam against SARS CoV-2 based on Network Pharmacology and Molecular Docking analysis. Combinatorial Chemistry and High Throughput Screening. 2023;26(2):436-447. doi: 10.2174/1386207325666220519112846. PMID: 35598237.

Year : 2022

Evaluation of the active constituents of Nilavembu Kudineer for viral replication inhibition against SARS‐CoV‐2: An approach to targeting RNA‐dependent RNA polymerase (RdRp)

Cite this Research Publication : Kuriakose A, Nair B, Abdelgawad MA, Adewum AT, Soliman MES, Mathew B, Nath LR. Evaluation of the active constituents of Nilavembu Kudineer for viral replication inhibition against SARS-CoV-2: An approach to targeting RNA-dependent RNA polymerase (RdRp). Journal of Food Biochemistry. 2022 Nov;46(11):e14367. doi: 10.1111/jfbc.14367. Epub 2022 Aug 22. PMID: 35994404; PMCID: PMC9539176.

Year : 2022

2,4-Dihydroxycinnamic acid as spike ACE2 inhibitor and apigenin as RdRp inhibitor in Nimbamritadi Panchatiktam Kashayam against COVID-19: an in silico and in vitro approach

Cite this Research Publication : Murali M, Nair B, Vishnu VR, Aneesh TP, Nath LR. 2,4-Dihydroxycinnamic acid as spike ACE2 inhibitor and apigenin as RdRp inhibitor in Nimbamritadi Panchatiktam Kashayam against COVID-19: an in silico and in vitro approach. Molecular Diversity. 2022 Nov 10:1–11. doi: 10.1007/s11030-022-10552-z. Epub ahead of print. PMID: 36357813; PMCID: PMC9648999.

Year : 2022

Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma

Cite this Research Publication : Nath LR, Swetha M, Vijayakurup V, Thangarasu AK, Haritha NH, Shabna A, Aiswarya SU, Rayginia TP, Keerthana CK, Kalimuthu K, Sundaram S, Lankalapalli RS, Pillai S, Towner R, Isakov N, Anto RJ. Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma. Frontiers in oncology. 2022 Feb 8;12:812598. doi: 10.3389/fonc.2022.812598. Erratum in: Frontiers in oncology, 2022 Aug 25;12:991401. PMID: 35211405; PMCID: PMC8861526.

Year : 2021

Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions

Cite this Research Publication : Mathew, B., Oh, J.M., Khames, A., Mathew, G.E., Kim, H. Replacement of chalcone-ethers with chalcone-thioethers as potent and highly selective monoamine oxidase-b inhibitors and their protein-ligand interactions, Pharmaceuticals, 2021, 14(11),1148, DOI: 10.3390/ph14111148

Publisher : Pharmaceuticals

Year : 2021

Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets

Cite this Research Publication : Kumar AR, Devan AR, Nair B, Vinod BS, Nath LR. Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets. Mol Biol Rep. 2021 Dec;48(12):8075-8095. doi: 10.1007/s11033-021-06752-9. Epub 2021 Oct 20. PMID: 34671902; PMCID: PMC8605995.

Publisher : Molecular Biology Reports

Year : 2021

Critical biomarkers of hepatocellular carcinoma in body fluids and gut microbiota

Cite this Research Publication : Nath LR, Murali M, Nair B. Critical biomarkers of hepatocellular carcinoma in body fluids and gut microbiota. World Journal of Gastrointestinal Oncology. 2021 Dec 15;13(12):2219-2222. doi: 10.4251/wjgo.v13.i12.2219. PMID: 35070054; PMCID: PMC8713307.

Year : 2021

The Impetus of COVID -19 in Multiple Organ Affliction apart from Respiratory Infection

Cite this Research Publication : Bilha Baby, Aswathy R. Devan, Bhagyalakshmi Nair, and Lekshmi R Nath, “The Impetus of COVID -19 in Multiple Organ Affliction apart from Respiratory Infection”, Pathogenesis, Diagnostic Measures and Current Treatment Strategy, Infectious Disorders-Drug targets, 2021, 21(4), pp. 514-526.

Publisher : Infectious Disorders-Drug targets

Year : 2021

Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma

Cite this Research Publication : Devan AR, Kumar AR, Nair B, Anto NP, Muraleedharan A, Bijo Mathew, Kim H, and Nath LR, “Insights into an Immunotherapeutic Approach to Combat Multidrug Resistance in Hepatocellular Carcinoma”, Pharmaceuticals, vol. 14, no. 7, p. 656, 2021.

Publisher : Pharmaceuticals

Year : 2021

Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.

Cite this Research Publication : P. Koyiparamb Vishal, Oh, J. Min, Khames, A., Abdelgawad, M. A., Nair, A. Sujathan, Nath, L. R., Gambacorta, N., Ciriaco, F., Nicolotti, O., Kim, H., and Bijo Mathew, “Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders.”, Pharmaceutics, vol. 13, no. 6, 2021.

Publisher : Pharmaceutics

Year : 2021

MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy.

Cite this Research Publication : Chameli Ratan, Dixon Dalia Cici Kattiparambil, Bhagyalakshmi Nair, and Lekshmi R Nath, “MUC glycoproteins: Potential biomarkers and molecular targets for cancer therapy.”, Current Cancer Drug Targets, 2021, 21(2), pp. 132-152

Publisher : Current cancer drug targets

Year : 2021

The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.

Cite this Research Publication : Sherin Joseph, Bhagyalakshmi Nair, and Lekshmi R Nath, “The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.”, Curr Mol Med, 2021.

Publisher : Current Molecular Medicine

Year : 2021

Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.

Cite this Research Publication : Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R. Kumar, Jaggaiah N. Gorantla, Aishwarya T. S., and Lekshmi R Nath, “Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.”, Curr Pharm Biotechnol, 2021.

Publisher : Curr Pharm Biotechnol

Year : 2021

RNA sensors as a mechanism of innate immune evasion among SARS-CoV2, HIV and Nipah viruses.

Cite this Research Publication : Dixon Dalia Cici Kattiparambil, Chameli Rata, Bhagyalakshmi Nair, Sabitha Mangalath, Rachy Abraham, and Lekshmi R Nath, “RNA sensors as a mechanism of innate immune evasion among SARS-CoV2, HIV and Nipah viruses.”, Curr Protein Pept Sci, 2021.

Publisher : Curr Protein Pept Sci

Year : 2021

Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment.

Cite this Research Publication : Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, and Lekshmi R Nath, “Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment.”, Current drug targets, 2021, 22(11), pp. 1288-1316

Publisher : Curr Drug Targets

Year : 2021

An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease.

Cite this Research Publication : Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R. Kumar, and Lekshmi R Nath, “An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease.”, Biotechnology and Applied Biochemistry, 2021.

Publisher : Biotechnology and Applied Biochemistry (Article in Press)

Year : 2021

Curry Versus Cancer: Potential of Some Selected Culinary Spices Against Cancer with in vitro, in Vivo, and Human Trials Evidences

Cite this Research Publication : A. J. Kammath, Nair, B., P, S., and Lekshmi R Nath, “Curry Versus Cancer: Potential of Some Selected Culinary Spices Against Cancer with in vitro, in Vivo, and Human Trials Evidences”, Journal of Food Biochemistry Special issue – Pharma Food, 2021, 45(3),e13285

Publisher : Journal of Food Biochemistry Special issue – Pharma Food

Year : 2021

The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review

Cite this Research Publication : Adithya J., Bhagyalakshmi Nair, Aishwarya S., and Lekshmi R Nath, “The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review”, Current Pharmaceutical Biotechnology, 2021, 22(7), pp. 906-919

Publisher : Current Pharmaceutical Biotechnology

Year : 2020

Inevitable role of TGF-β1 in the progression of nonalcoholic fatty liver disease

Publisher : Journal of Receptors and Signal Transduction.

Year : 2020

Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: an In silico Approach

Cite this Research Publication : Siniprasad P, Nair B, Balasubramaniam V, Sadanandan, Prashant, Namboori P K, Nath L R. Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach. Letters in Drug Design & Discovery, 2020, 17 (11), 1401-1408. doi: 10.2174/1570180817999200623115703

Publisher : Letters in Drug Design & Discovery

Year : 2020

The Impetus of COVID -19 in Multiple Organ Affliction Apart from Respiratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy

Cite this Research Publication : B. Baby, Aswathy R. Devan, and Nath*, B. Nair and L., “The Impetus of COVID -19 in Multiple Organ Affliction Apart from Respiratory Infection: Pathogenesis, Diagnostic Measures and Current Treatment Strategy”, Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders), vol. 20. pp. 1-13, 2020.

Publisher : Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)

Year : 2020

Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An in Silico and in Vitro Approach

Cite this Research Publication : B. Nair, Anto, R. John, Dr. Sabitha M., and Lekshmi R Nath, “Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An in Silico and in Vitro Approach”, Adv Pharm Bull, vol. 10, no. 3, pp. 472-476, 2020.

Publisher : Adv Pharm Bull, Tabriz University of Medical Sciences

Year : 2016

In Vitro Evaluation of the Antioxidant, 3,5-Dihydroxy-4-Ethyl-Trans-Stilbene (DETS) Isolated from Bacillus Cereus as a Potent Candidate Against Malignant Melanoma

Cite this Research Publication : Lekshmi R Nath, Kumar, S. N., Das, A. A., Nambisan, B., Shabna, C. Mohandas, and Anto, R. J., “In Vitro Evaluation of the Antioxidant, 3,5-Dihydroxy-4-Ethyl-Trans-Stilbene (DETS) Isolated from Bacillus Cereus as a Potent Candidate Against Malignant Melanoma”, Frontiers in Microbiology, vol. 7, no. 452, 2016

Publisher : Frontiers in Microbiology .

Year : 2016

Evaluation of Uttroside B, a Saponin from Solanum Nigrum Linn, as a Promising Chemotherapeutic Agent Against Hepatocellular Carcinoma

Cite this Research Publication : Lekshmi R Nath, Gorantla, J. N., Thulasidasan, A. T., Vijayakurup, V., Shah, S., Anwer, S., Joseph, S. M., Antony, J., Veena, K. Suresh, Sundaram, S., Marelli, U. K., Lankalapalli, R. S., and Anto, R. John, “Evaluation of Uttroside B, a Saponin from Solanum Nigrum Linn, as a Promising Chemotherapeutic Agent Against Hepatocellular Carcinoma”, Sci. Rep. 2016, vol. 6, 2016

Publisher : Sci. Rep. 2016 .

Year : 2015

Kaempferide, the Most Active Among the Four Flavonoids Isolated and Characterized from Chromolaena Odorata, Induces Apoptosis in Cervical Cancer Cells While Being Pharmacologically Safe

Cite this Research Publication : Lekshmi R Nath, Gorantla, J. N., Joseph, S. Margaret, Antony, J., Thankachan, S., Menon, D. B., S. Sankar, Lankalapalli, R. S., and Anto, R. John, “Kaempferide, the Most Active Among the Four Flavonoids Isolated and Characterized from Chromolaena Odorata, Induces Apoptosis in Cervical Cancer Cells While Being Pharmacologically Safe”, RSC Advances, vol. 5, pp. 100912-100922, 2015

Publisher : RSC Advances

Year : 2015

DW-F5: A Novel Formulation Against Malignant Melanoma from Wrightia Tinctoria

Cite this Research Publication : J. Antony, Saikia, M., .V, V., Lekshmi R Nath, Katiki, M. Rao, Murty, M. S. R., Paul, A., A, S., Chandran, H., Joseph, S. Margaret, S, N. Kumar., Panakkal, E. Jayex, I.V, S., I.V, S., Ran, S., S, S., Rajan, E., and Anto, R. John, “DW-F5: A Novel Formulation Against Malignant Melanoma from Wrightia Tinctoria”, Scientific Reports, 2015

Publisher : Scientific Reports

Year : 2014

[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling

Cite this Research Publication : R. E. K, Bava, S. V., Narayanan, S. Shyam, Lekshmi R Nath, Thulasidasan, A. Kumar, V, S. E., and Anto, R. John, “[6]-Gingerol Induces Caspase-Dependent Apoptosis and Prevents PMA-Induced Proliferation in Colon Cancer Cells by Inhibiting MAPK/AP-1 Signaling”, PLOS ONE, vol. 9, no. 8, 2014

Publisher : PLOS ONE

Year : 2010

General approaches towards extraction of medicinal plants

Publisher : Amala Research Bulletin

Year : 2010

Anti-inflammatory activity of Mirabilis jalapa linn. Leaves

Cite this Research Publication : Lekshmi R Nath, KP, M., RV, S., and KS, A., “Anti-inflammatory activity of Mirabilis jalapa linn. Leaves”, J Basic Clin Pharm, vol. 1, no. 2, 2010

Publisher : J Basic Clin Pharm

Year : 2009

Pharmacognostical and Phytochemical Studies of Mirabilis jalapa Linn. leaves

Cite this Research Publication : Lekshmi R Nath, KP, M., RV, S., and K.S, A., “Pharmacognostical and Phytochemical Studies of Mirabilis jalapa Linn. leaves”, Pharmacognosy Journal, vol. 1, no. 2, pp. 111 - 115, 2009

Publisher : Pharmacognosy Journal

Patents

Year : 2016

Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma

Cite this Research Publication : Lekshmi R Nath and Anto, R. John, “Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma”, U.S. Patent 2016410184012016.

Publisher : Number 201641018401, India .

Patents
  • Ruby John Anto and Lekshmi R Nath, Uttroside B and derivatives thereof as therapeutics for hepatocellular carcinoma, Filed on 28 May 2016. Funding by Rajiv Gandhi Centre For Biotechnology.

Patent Application No. 201641018401

Current Status: PCT/IN2017/050204

WO2017208254A1

  • National Patent Application No. 201641018401 dated 28th May 2016
  • International patent Application No. PCT/ IN20 17/050204 dated 27th May 2017
  • Ph.D. findings on hepatocellular carcinoma recently received US, Canada, Japan & South Korea Patent (WO 2017208254 A1,Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma”.
  • USFDA has recently granted an orphan drug designation to the small molecule chemotherapeutic UttrosideB against hepatocellular carcinoma.

Technology transfer/commercialization

Transferred the technology to Q Biomed, USA. Patent royalty payment received.

Uttroside B and Derivatives Thereof as Therapeutics for Hepatocellular Carcinoma (PCT/ IN20 17/050204 dated 27th May 2017) (https://adisinsight.springer.com/drugs/800048876); https://qbiomed.com/index.php/pipeline/uttroside)

Research

Research Grant

MOU was made on 21-12-2023 by and between Eubelle Naturals, having its Registered Office at 8/161, Manakkadavu, Cochin, Kerala, and Amrita School of Pharmacy (Principle Investigator on the collaborative work entitled “Biological evaluation of Nutraceuticals”)

Ongoing Projects

  • Amrita Vishwa Vidyapeetham Seed Grant 2024-2025
    Principal Investigator
    Preclinical evidence of Neoadjuvant Therapy with Phytochemicals against hepatocellular carcinoma
  • Amrita Vishwa Vidyapeetham Seed Grant 2022-2023
    Principal Investigator
    Development of an affordable animal model for NAFLD / NASH studies
  • Amrita Vishwa Vidyapeetham Seed Grant 2021-2022
    Principal Investigator
    Liposomal drug delivery of phytochemical against Hepatocellular carcinoma
  • KSCSTE Project
    Principal Investigator
    Duration: January 2020 – January 2021
    Comparative evaluation of Kaempferol and its semisynthetic derivative as mTORC1 inhibitor against hepatocellular carcinoma: An in-vitro approach.
  • Amrita Vishwa Vidyapeetham Seed Grant 2018-19
    Principal Investigator
    Duration: April 2018 – May 2019
    Chemo sensitizing property of phytochemicals in improving the efficacy of marketed drugs for liver cancer.

Research Interest

  • Nutraceuticals and life style disorders-Sustainable development goal 3 (fight communicable diseases; ensure reduction of mortality from non-communicable diseases)
  • Hepatocellular carcinoma & Phytomedicine -Cell death mechanism, Chemoprevention & Chemotherapy
  • Biomarker analysis in liver disorders- Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH) and HCC

Faculty Research Interest

  • Nutraceuticals and lifestyle disorders-Sustainable development goal 3
  • Phytomedicine and Cancer biology- Sustainable development goal 3
  • Hepatocellular Carcinoma- Chemoprevention and Chemotherapy
  • Biomarkers in Liver disorders
  • Non-alcoholic fatty liver disease (NAFLD)
  • Non-alcoholic steatohepatitis (NASH)

PhD students- 4 (Ongoing)

Number of PG students Guided ( Completed): 11

Number of PG students (Ongoing): 2

Achievements and Awards
  • Recipient of AIRA 2023 Publication Merit Award & Certificate of Appreciation for Research (Amrita Innovation and Research Awards to honour outstanding faculty, Amrita Vishwa Vidyapeetham)
  • Publication Grant Award  2022 for the Scopus indexed research paper from KSCSTE student project scheme.
  • Recipient of AIRA 2021 Publication Merit Award & Certificate of Appreciation for Research (Amrita Innovation and Research Awards to honour outstanding faculty, Amrita Vishwa Vidyapeetham).
  • Recipient of Bharat Vikas Award 2018from Institute of Self Reliance (ISR), the Press Club of Odisha, Bhubaneswar-1 on December 1, 2018, for the outstanding performance in the field of Cancer Chemoprevention.
  • WCP-NP Best Poster Presentation 2019at 5th IUPHAR World Conference on the Pharmacology of Natural products & 51st Annual Conference of Indian Pharmacological society held at ICMR, National Institute of Nutrition, Hyderabad, India on 5-7 December 2019.
  • Senior Research Fellowship(SRF) from Indian Council of Medical Research (ICMR) in February 2011
  • OMICS International Best Poster Awardat the 8th Euro biotechnology congress, Frankfurt Main, Germany, August 2015
  • Best paper Awardunder Biotechnologycategory for oral presentation at 28th Kerala Science Congress, University of Calicut Campus, Thenhipalam, Malappuram District, India, January 2016
  • Best Oral Presentation awardin the “International Conference on Neutraceuticals in Chronic Disease-2016 held at Kochi, Kerala, India, September 2016
  • Dr M.R. Das Career Awardin recognition of the Professional achievement during PhD tenure in RGCB, December 2016
  • Kerala State Council for Science, Technology and Environment(KSCTEC) Best Paper Award for Project “Mechanistic evaluation of the anti-tumour effect of SN2, the active principle of Solanum nigrum Linn in hepatocellular carcinoma, 2016 July-December 2017.
Membership
  • “Society for Nutraceuticals & Chronic Diseases” Life member LM44
  • IACRLife Membership No – LM-1298
  • Indian National association for the study of the Liver
  • European association of cancer Research (Membership number: EACR26534)
Reviewer
  1. Natural Product Research, Taylor and Francis
  2. World Journal of Gastroenterology, Baishideng Publishing Group Inc
  3. MDPI journals( International Journal of Environmental Research and Public Health, Processes)
  4. Cellular and Molecular Biology Letters, BMC
  5. Annals of Medicine, Taylor and Francis
  6. Pharmaceutical Biology, Pharmaceutical Biology
  7. Expert Opinion on Pharmacotherapy, Expert Opinion on Pharmacotherapy
  8. World Journal of Pharmacology, Baishideng Publishing Group Inc
  9. Bioengineered, Taylor and Francis
  10. World Journal of Clinical cases, Baishideng Publishing Group Inc
  11. Chemistry & Biodiversity, Wiley
  12. Cell Transplantation
  13. ACS Pharmacology and Translational Medicine
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