Qualification: 
Ph.D, MDS, BDS
manjuv@aims.amrita.edu

Dr. Manju V. currently serves as Professor at the Department of Prosthodontics and Implantology, School of Dentistry, Kochi and Consultant Maxillofacial Prosthodontist at Department of Head & Neck Surgery, Amrita Institute of Medical Sciences. Dr. Manju has undergone additional training in Maxillofacial Prosthodontics. She joined the Department of Prosthodontics and Implantology at Amrita in 2004. She is also associated with Maxillofacial Prosthetic Division, School of Dentistry, University of California (UCLA) as Visiting Professor in 2018.

Education

  • Ph. D.: Amrita Vishwa Vidyapeetham
  • MDS: Govt.Dental College, Trivandrum, University of Kerala, India.
  • BDS: Govt.Dental College, Trivandrum, University of Kerala, India.

Achievements

  • International Award – ‘Creative circle award’ for new innovations in Maxillofacial Prosthetics, Int. society for Maxillofacial Rehabilitation conference held at Bangkok, September 2008.
  • Visiting Professor- Maxillofacial Prosthetic Division at University of California, Los Angeles (UCLA) in 2018
  • Board of Studies member, Kerala University of Health Sciences.
  • AOCMF – Regional faculty
  • Invited speaker for several National & International conferences
  • Conducts Hands-on training programmes in Maxillofacial Prosthetics

Invited Speaker – National / International Conferences

  • Invited Speaker: for conducting a session on ‘Nanotechnology and Lasers in Prosthodontics” organized by Indian Prosthodontic Society- Kerala State branch in association with Kerala University of Health Sciences on February 21-23, 2019.
  • Invited Faculty for Hands-on Training and Guest Lecture: 2 days conference on Maxillofacial Prosthodontics: Building Competencies to Enhance Outcome, held at VSPM Dental College & Research Centre, Nagpur; organized by Indian Prosthodontic society, Nagpur branch, on February 16-17, 2019
  • Guest Speaker: Oral Cancer Symposium conducted at Azeezia College of Dental Sciences & research on February 4-5, 2019
  • Keynote Speaker: 46th Indian Prosthodontic Society Conference held in Mangalore from November 15-18, 2018
  • Invited Speaker: ONCO QUEST ’18 – A Comprehensive CDE on Oral Cancer – from Etiology to Rehabilitation, held at Rajas Dental College, Nagercoil, on September 7, 2018.
  • Invited Speaker: Indian Prosthodontic Society – Kerala State branch Conference, April 2018.
  • UCLA: Invited for Research and Educational Collaborations at Maxillofaicial Prosthetic Division of UCLA School of Dentistry (April 2018)
  • Invited Faculty: “The Reconstruction Summit” conducted by Dr. Dennis Rohner (Hirslanden Medical Center, Switzerland) held at Pune, December 2017.
  • Invited Speaker: International Conference on Comprehensive Management of Head and Neck Tumours: Current Perspective at Aster Medcity, Kochi, May 2017.
  • Organizing Secretary: International Conference on Maxillofacial Rehabilitation (Foundation for Orofacial Rehabilitation Outreach Program) held at Amrita Institute of Medical Sciences, Kochi, March 2017
  • Keynote Speaker: Symposium on Oral Cancer hosted by Cochin Periodontists Society held at Kochi; March 2017. Topic: Prosthetic Rehabilitation in Oral Cancer Patients.
  • Guest Speaker: Indian Prosthodontic Society Conference held at Bombay, November 2016. Topic: Surgical and Prosthetic Management of Mandibulectomy Defects.
  • Invited Faculty: AOCMF-Asia Pacific ; Training in Secondary Management of Post Traumatic Defects; September 2016
  • Invited Faculty: Head & Neck Training Program, Ruby Hall Cancer Centre, Pune, February 2015.
  • Speaker: Int. Society for Maxillofacial Rehabilitation Conference’ X’ian, China, 2014. Topic: Application of Tissue Engineering in Maxillofacial Rehabilitation.
  • Course Coordinator & Faculty: Maxillofacial prosthetic Workshop. Head & Neck supportive oncology training program held at Amrita Institute, March 2014.
  • Invited Speaker: Conducted Faculty Training Program in Vidyodaya School. Topic: Medical Application of Tissue Engineering, 2014
  • Invited Faculty: AOCMF- Asia Pacific Symposium –Advances in Maxillofacial Reconstruction & Rehabilitation. November 2014, Bangalore.
  • Young Star Speaker: Indian Prosthodontic Society Conference, Ahmedabad 2013.Topic: Recent Advances in Maxillofacial Prosthetics.
  • Peer Reviewer of Journal of Odontologic Research; official publication of Indira Gandhi Institute of Dental Sciences, since November 2012.
  • National Faculty: AOCMF Advances Seminar on Maxillofacial Reconstruction; August 2012, Kochi. Topic: Orbital Defects Rehabilitation
  • Invited Speaker: Association of Prosthodontist and Implantologist of Kerala; Mar Baselious College, 2012. Kerala. Topic: Prosthetic Rehabilitation of Maxillofacial Defects.
  • Young Star Speaker: IPS-AAP Indian & Asian Academy of Prosthodontics Conference, Chennai. Topic: Application of Rapid Prototyping Technology in Prosthetic Rehabilitation of Maxillofacial Defects.
  • Course Co-ordinator & Faculty: ‘Amrita Head and Neck Supportive Oncology Meet’. (Dental Oncology, Swallowing, Prosthodontics, Pathology) February 2012, Kochi. Conducted Hands-on Maxillofacial Prosthetic module as part of Head & Neck Oncology Meet (2012).
  • Faculty: 7th AHEAD Amrita Comprehensive Head and Neck Oncology Teaching Program. February 2011.
  • Faculty: APLAST 2011- Amrita Tutorials in Plastic and Reconstructive Surgery; March 2011.
  • Guest Speaker: 38th Indian Prosthodontic Society Conference, November 2010, Indore. “Treatment Planning for Implant Supported Prosthesis.”
  • Preconference Course Faculty: Association of Oral and maxillofacial surgeons’ National Conference in Accord with British Association of Maxillofacial Surgeons., Kochi, November 2009 (Topic: Craniofacial Implants)
  • Conducted Preconference Course: 37th Indian Prosthodontic Society Conference. November 2009, Trissur, Kerala. Topic: Implant-supported Auricular Prosthesis.
  • Convenor: Entertainment -37th Indian Prosthodontic Society Conference, Kerala, 2009.
  • Invited Speaker: 9th Annual Meeting of the Foundation for Head & Neck Oncology; Amrita Institute, Kochi, October 2009.
  • Guest Speaker. CME Programme conducted for the Association of Plastic Surgeons of India (APSI) & ETHICON Institute of surgical education held at Kochi, October 2009.
  • Speaker: Int. Society for Maxillofacial Rehabilitation Conf 2008. Bangkok, Thailand.
  • Invited Faculty: Indian Dental Association conference held at Nedumbassery, Kochi. November 2008.

Publications

Publication Type: Journal Article

Year of Publication Title

2019

Manju V., Iyer, S., Menon, D., Shantikumar V Nair, and Dr. Manitha B. Nair, “Evaluation of Osseointegration of Staged or Simultaneously Placed Dental Implants with Nanocomposite Fibrous Scaffolds in Rabbit Mandibular Defect”, Materials Science and Engineering C, vol. 104, 2019.[Abstract]


Implant-supported dental prosthesis in patients with edentulism or those with reconstructed bone have long survival rate, but the success depends largely on the quality and quantity of the available bone at the recipient site. The usage of autograft is the gold standard treatment for vertical bone augmentation, but it has many limitations. In this study, we have developed a nanocomposite fibrous scaffold [silica coated nanoHA-gelatin reinforced with electrospun poly(L-lactic acid) (PLLA) nanoyarns] and evaluated its efficacy to promote osseointegration in rabbit mandibular defect in comparison to the scaffold without fibers and commercial nanoHA-collagen graft. For this, critical sized bilateral defect (10 mm length, 3 mm depth and 3 mm width) was created in rabbit mandible and dental implantation was done in two manners. In strategy 1, Ti dental implant was placed along with the scaffold and in strategy 2, the scaffold was implanted for 3 months to facilitate new bone formation followed by Ti dental implantation. In strategy 2, the fibrous scaffold could promote new bone formation and osseointegration in rabbit mandibular defect when compared to the scaffolds without fibers and commercial graft, but strategy 1 was not successful. These findings demonstrated that nanocomposite fibrous scaffold is a promising biomaterial to promote new bone formation and osseointegration in mandibular defect. © 2019

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2018

B. A. S., Manju V., and K., G. V., “Effect of chemical disinfectants and accelerated aging on maxillofacial silicone elastomers: An In vitro Study”, Indian Journal of Dental Research , vol. 29, no. 1, pp. 67-73, 2018.[Abstract]


CONTEXT:
Maxillofacial prostheses need frequent refabrication due to degradation of color and deterioration of physical properties of the elastomer.

AIMS:
This study attempted to evaluate the change in color stability, Shore A hardness, and surface roughness of two maxillofacial silicones, A-2186 and Cosmesil M511, when submitted to chemical disinfection and accelerated aging.

SETTINGS AND DESIGN:
This was a comparative in vitro study.

SUBJECTS AND METHODS:
The materials included two silicone elastomers - A-2186 and Cosmesil M511 (Factor II Incorporated) - functional intrinsic red pigment and three disinfectants - Fittydent tablet, chlorhexidine gluconate 4%, and neutral soap. The specimens in each group of elastomer were evaluated initially for color, hardness, and surface roughness, which were further divided into subgroups and subjected to disinfection and accelerated aging. The evaluation of color was performed with the help of an ultraviolet reflectance spectrophotometer. Shore A hardness was evaluated using a durometer and surface roughness, with a digital roughness tester followed by scanning electron microscopy analysis.

STATISTICAL ANALYSIS USED: :
Analysis of variance and Tukey's multiple comparison test were used for statistical analysis.

RESULTS:
Accelerated aging caused a significant decrease in color, increase in Shore A hardness, and variation in surface roughness in both silicone elastomer groups. Chemical disinfection presented significant changes in color and surface roughness whereas no significant effect on Shore hardness, irrespective of the disinfectant used.

CONCLUSIONS:
The maxillofacial silicone elastomers presented deterioration in color, hardening, and significant variations in surface roughness when subjected to chemical disinfection and accelerated aging, which provides a valid baseline for future research.

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2018

Manju V., Anitha A., Dr. Deepthy Menon, Dr. Subramania Iyer K., Shantikumar V Nair, and Dr. Manitha B. Nair, “Nanofibrous yarn reinforced HA-gelatin composite scaffolds promote bone formation in critical sized alveolar defects in rabbit model”, Biomedical Materials, vol. 13, no. 6, p. 065011, 2018.[Abstract]


Alveolar ridge resorption and crestal bone loss necessitate the use of bone graft substitutes for dental rehabilitation. The aim of this study was to compare the bone regenerative property of nanofibre incorporated two composite matrices (nanofibrous sheet layered matrix (CS-S) and nanofibrous yarn reinforced matrix (CS-Y)) in critical sized mandibular defect in a rabbit model (under load bearing scenario). Histological evaluation revealed continuous bone formation in the defect implanted with fibre reinforced scaffolds than those without fibres as well as commercial nanoHA-collagen graft. Interestingly, the mineralisation and the mineral density were significantly higher with nanoyarn reinforced scaffolds. Moreover, the compressive strength of new bone formed from CS-Y scaffolds was almost similar to that of native rabbit mandible. It can be concluded that the mechanical strength provided by three-dimensionally reinforced nanoyarns in the matrix could promote bone formation in load bearing mandibular region, and these can be proposed as a scaffold of choice for alveolar bone augmentation and dental rehabilitation.

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2017

R. Sreeraj, Krishnan, V., Manju V., and Thankappan, K., “Comparison of Masticatory and Swallowing Functional Outcomes in Surgically and Prosthetically Rehabilitated Maxillectomy Patients.”, The International Journal of Prosthodontics, vol. 30, no. 6, pp. 573–576, 2017.[Abstract]


PURPOSE:
This study compared masticatory and swallowing functional outcomes in maxillectomy patients who underwent surgical and prosthetic rehabilitation or prosthetic rehabilitation only following surgical resection.

MATERIALS AND METHODS:
This comparative cross-sectional study involved 20 maxillectomy patients and compared their masticatory and swallowing functions following combined surgical and prosthodontic management vs an exclusively prosthodontic approach. Masticatory performance was measured by an originally modified sieve method using hydrocolloid material, and video fluoroscopic examination was employed for swallowing assessments.

RESULTS:
Masticatory performance was significantly better in the patient group treated with flaps and removable denture prostheses compared to patients treated with obturator prosthesis alone. Swallowing outcomes were comparable in both groups.

CONCLUSION:
Flap reconstruction followed by an obturator prosthesis seems to be a preferable option when planning for functional rehabilitation in maxillectomy patients. Further research is needed to substantiate the functional outcomes noted in this study.

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2016

A. S. Babu, Manju V., Nair, V. P., and Thomas, T., “Prosthetic rehabilitation of surgically treated orbital defects - Evisceration, enucleation, and exenteration: A case series”, Journal of Indian Prosthodontist Society, vol. 16, pp. 216-220, 2016.[Abstract]


The rehabilitation of a patient who has suffered the psychological trauma due to loss of an eye requires a prosthesis that will provide the optimum cosmetic and functional result. The mode of rehabilitation varies based on the type of defect and surgical approach being adopted. A case series of prosthetic rehabilitation of three types of orbital defects - evisceration, enucleation and exenteration have been reported in this article. The clinical relevance of surgical approaches highlights the preservation of remaining anatomic structures creating a negative space or concavity to aid in future prosthetic rehabilitation. A multidisciplinary management and team approach is essential in providing esthetics and to regain the confidence. Follow-up care for the patient is mandatory. © 2016 The Journal of Indian Prosthodontic Society. More »»

2015

B. Halima Shamaz, Anitha, A., Manju V., Kuttappan, S., Shantikumar V Nair, and Dr. Manitha B. Nair, “Relevance of fiber integrated gelatin-nanohydroxyapatite composite scaffold for bone tissue regeneration”, Nanotechnology, vol. 26, no. 40, p. 405101, 2015.[Abstract]


Porous nanohydroxyapatite (nanoHA) is a promising bone substitute, but it is brittle, which limits its utility for load bearing applications. To address this issue, herein, biodegradable electrospun microfibrous sheets of poly(L-lactic acid)-(PLLA)–polyvinyl alcohol (PVA) were incorporated into a gelatin–nanoHA matrix which was investigated for its mechanical properties, the physical integration of the fibers with the matrix, cell infiltration, osteogenic differentiation and bone regeneration. The inclusion of sacrificial fibers like PVA along with PLLA and leaching resulted in improved cellular infiltration towards the center of the scaffold. Furthermore, the treatment of PLLA fibers with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide enhanced their hydrophilicity, ensuring firm anchorage between the fibers and the gelatin–HA matrix. The incorporation of PLLA microfibers within the gelatin–nanoHA matrix reduced the brittleness of the scaffolds, the effect being proportional to the number of layers of fibrous sheets in the matrix. The proliferation and osteogenic differentiation of human adipose-derived mesenchymal stem cells was augmented on the fibrous scaffolds in comparison to those scaffolds devoid of fibers. Finally, the scaffold could promote cell infiltration, together with bone regeneration, upon implantation in a rabbit femoral cortical defect within 4 weeks. The bone regeneration potential was significantly higher when compared to commercially available HA (Surgiwear™). Thus, this biomimetic, porous, 3D composite scaffold could be offered as a promising candidate for bone regeneration in orthopedics.

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2014

J. S.T., K., T., Mathew, J., Manju V., Sharma, M., and Iyer, S., “Defect components and reconstructive options in composite orbitomaxillary defects with orbital exenteration”, Journal of Oral and Maxillofacial Surgery, vol. 72, pp. 1869.e1-1869.e9, 2014.[Abstract]


Purpose The conventional way of reconstructing an orbital exenteration defect associated with a maxillectomy is to cover it with a soft tissue free flap and camouflage it with a spectacle-mounted orbital prosthesis. Also, there are some reports on the use of bone flaps. The objective of this study was to review the reconstructive options for a defect resulting after orbital exenteration and maxillectomy. Materials and Methods This study concerns a retrospective case series of 20 patients. Electronic medical records, including clinical details, operative notes, and follow-up data, were analyzed. Defects were analyzed for their reconstructive components. The reconstructive methods used were studied by the types of flap used, bony versus soft tissue types of reconstruction, and the prosthetic method used to rehabilitate the eye. Outcomes were analyzed for flap success rate. Descriptive methods for data analysis were used. Results Fourteen patients underwent a soft tissue reconstruction alone and 6 underwent bony reconstruction. The free rectus abdominis was the commonest soft tissue flap used. This article presents the outcome of reconstruction in such patients and the utility of individual flaps for their ability to replace different components of the defect. Conclusions Ideal reconstruction should address all individual defect components of facial contour, orbital, palatal, skull base, and skin defects. The free rectus abdominis flap remains the common choice. When a composite socket reconstruction is to be achieved, the innovative free tensor fascia lata flap with the iliac crest bone and internal oblique muscle is an option. © 2014 American Association of Oral and Maxillofacial Surgeons.

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2013

Manju V. and Sreelal T., “Mandibular Implant-Supported Overdenture: An In Vitro Comparison of Ball, Bar, and Magnetic Attachments”, Journal of Oral Implantology, vol. 39, no. 3, pp. 302-307, 2013.[Abstract]


In an implant-supported overdenture, the optimal stress distribution on the implants and least denture displacement is desirable. This study compares the load transfer characteristics to the implant and the movement of overdenture among 3 different types of attachments (ball-ring, bar-clip, and magnetic). Stress on the implant surface was measured using the strain-gauge technique and denture displacement by dial gauge. The ball/O-ring produces the optimal stress on the implant body and promotes denture stability.

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2009

Manju V. and Vinodkrishnan, “Ocular defects Rehabilitation”, Amrita Journal of Medicine, vol. 5, no. 1, 2009.

2009

Anil Mathew, Kepanasseril, A., Gopikrishnan,, and Manju V., “Assessment of the rheological properties of poly methyl methacrylate incorporated with 30% volume of highly drawn linear polyethylene fibres: An invitro study”, Amrita Journal of Medicine, vol. 5, no. 1, pp. 27-34, 2009.

2009

Manju V. and Nair, V. P., “Fabrication of silicone auricular prosthesis”, Amrita Journal of Medicine, vol. 5, no. 1, 2009.

2009

Manju V. and Anil Mathew, “Case Report - Prosthetic rehabilitation of facial defect with silicone prosthesis”, Kerala Dental Journal , vol. 32, no. 3, 2009.

Research

Major Projects

  • Completed:
    • Nano Yarn Reinforced Composite for Native Bone Augmentation and Endosseous Dental Implants.
      Funding Agency: Thematic Unit of Excellence and Thematic Projects on Frontiers of Nano Science and Technology (TPF-Nano) Grant, Department of Science and Technology (DST), Government of India (under Amrita Center for Nanosciences and Molecular Medicine)
  • On-going
    • Evaluation of Nanotextile Reinforced Bone Regeneration Scaffold
      Funding Agency: TPF-MEDICALNANO, Department of Science and Technology. (under Amrita Center for Nanosciences and Molecular Medicine)

Minor Projects

  • Comparative Evaluation of Auricular Prosthesis Fabricated by Conventional method and Rapid Prototyping Technology – Pilot study (Scientific paper presented- ISMR conference, 2008, Bangkok)
  • Comparison of Tissue-engineered Bone Substitutes for Native Bone Augmentation - An In Vivo Study (Scientific paper presentation: ISMR conference, X’ian 2014).
  • “Mandibular Implant-supported Overdenture” – An Invitro Comparison of Ball, Bar, and Magnetic Attachments. (Published)
  • Assessing Tooth Colour in Edentulous Patients Based on Skin Colour for Complete Denture Fabrication.
  • Comparison of Functional Outcomes in Surgically and Prosthetically Rehabilitated Maxillectomy Patients. (Published)
  • Effect of Chemical Disinfectants and Accelerated Ageing on Maxillofacial Silicon Elastomers (Published)
  • Evaluation of Quality of Life of Mandibulectomy Patients after Surgical Reconstruction and Prosthetic Rehabilitation (Accepted for publication)
  • Thermal Changes at Implant Osteotomy Site with Variation in Drilling Speed, Pressure and Irrigation Temperature: An Invitro Study.
  • Effect of Nano Oxides on the Color Stability and Mechanical Properties of Maxillofacial Silicon Elastomers (in press)