LECTURE WISE CONTENTS:
UNIT I – Errors 3 hours
- Sources of errors, Types, methods of minimizing errors (2 hours)
- Accuracy, precision and significant figures (1 hour)
UNIT II – Volumetric Analysis 2 hours
- Significant Terms in volumetric analysis, Types of titration methods (1 hour)
- Methods of expressing concentration (1 hour)
Acid-base titration 3 hours
- Theories of acid base indicators (1 hour)
- Classification of acid base titrations – Acidimetry & Alkalimetry (1 example each) & applications (2 hours)
Redox titrations 3 hours
- Concepts of oxidation and reduction, Types of redox titrations (1 hour)
- Principles and applications of Cerimetry, Iodimetry, Iodometry (2 hours) (1 example each)
Non aqueous titration 3 hours
- Solvents, Acidimetry and alkalimetry titration (1 example each) (2 hours)
- Estimation of Ephedrine HCl , Applications. (1 hour)
Precipitation titrations 2 hours
- Mohr‘s method, Volhard‘s, (1 hour)
- Modified Volhard ‘s, Fajans method (1 example) (1 hour)
Complexometric titration 3 hours
- Classification, metal ion indicators (1 hour)
- Masking and damasking reagents, Estimation of Calcium gluconate, Applications (2 hours)
Gravimetry 3 hours
- Principle and steps involved in gravimetric analysis (1 hour)
- Estimation of barium (1 hour),
Relevance of AI assisted Analytical methods to detect impurities in Pharmaceutical Preparations – An Introduction (1 hour)- SDG9
UNIT III – Limit Test 4 hours
- Sources and types of impurities (1 hour)
- Principle & Procedure involved in the limit test
- Chloride, Sulphate, Iron, Arsenic (1 hour)
- Lead and Heavy metals, Modified limit test for Chloride and Sulphate (1 hour)
Sustainable practices in pharmaceutical Inorganic preparations to ensure quality and safety. (SDG-3)- 1hour
UNIT IV – Medicinal Gases 2 hours
- Oxygen* (preparation, Assay), Carbon Dioxide, Helium (1 hour)
- Nitrous Oxide, Nitric Oxide, Nitrogen, Carbon Monoxide (1 hour) (properties, uses, storage)
UNIT V – Pharmaceutically Important Inorganic Compounds
General methods of preparation, assay for the compounds superscripted with an asterisk (*), properties, medicinal uses and storage conditions of inorganic compounds belonging to the following classes.
- Gastro Intestinal Agents:
Acidifiers 1 hour
- Ammonium chloride* and HCl (1 hour)
Antacid 2 hours
- Definition, classification, Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate* (1 hour)
- Aluminum hydroxide gel, Magnesium hydroxide mixture (1 hour)
Cathartics 1 hour
- Mechanisms, Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite (1 hour)
- Electrolyte Replenishers 3 hours
- Functions of major physiological ions (1 hour)
- Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* (1 hour)
- Oral Rehydration Salt (ORS), Physiological acid base balance (2 hours)
- Antimicrobials 3 hours
- Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*(2 hours)
- Chlorinated lime*, Iodine and its preparations (1 hour)
- Dental Products 2 hours
- Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents: Strontium Chloride, Zinc Chloride, ((1 hour)
- Calcium carbonate, Sodium fluoride, and Zinc eugenol cement (1 hour)
- Miscellaneous compounds 4 hours
- Expectorants: Potassium iodide, Ammonium chloride*. (1 hour)
- Emetics: Copper sulphate*, Sodium potassium tartarate (1 hour)
- Haematinics: Ferrous sulphate*, Ferrous gluconate, Astringents: Zinc Sulphate, Potash Alum (1 hour)
- Poison & Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite (1 hour)
UNIT VI – Radiopharmaceuticals 4 hours
- Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations (2 hours)
- Half-life, radio isotopes (1 hour)
- Storage conditions precautions & pharmaceutical application of radioactive (1 hour)
UNIT VII – Pharmaceutical aids 2 hours
Definition, properties and uses
- Acidifiers & Alkalisers, Absorbents & Adsorbents (Aluminium Sulphate), Antioxidants & Preservatives (Sodium bisulphite, Sodium metabisulphite) (1 hour)
- Desiccants, Excipients (Magnesium stearate), Suspending agents (Bentonite), Filter aids, Colorants, Tonicity adjusting agents, Solvent & vehicles (water for injection), Flavoring & Sweetening agents. (1 hour)