Course

‘Pharmaceutical Organic Chemistry – Practical’ is a course offered in the first year of Pharm. D. program at School of Pharmacy, Health Sciences campus, Amrita Vishwa Vidyapeetham.

Course Duration: 3 Hrs./Week

List of Experiments:

1. Introduction to the various laboratory techniques through demonstration involving synthesis of the following compounds (at least 8 compounds to be synthesised):
   1. Acetanilde / aspirin (Acetylation)
   2. Benzanilide / Phenyl benzoate (Benzoylation)
   3. P-bromo acetanilide / 2,4,6 – tribromo aniline (Bromination)
   4. Dibenzylidene acetone (Condensation)
   5. 1-Phenylazo-2-napthol (Diazotisation and coupling)
   6. Benzoic acid / salicylic acid (Hydrolysis of ester)
   7. M-dinitro benzene (Nitration)
   8. 9, 10 – Antharaquinone (Oxidation of anthracene) / preparation of benzoic acid from toluene or benz- aldehyde
   9. M-phenylene diamine (Reduction of M-dinitrobenzene) / Aniline from nitrobenzene
   10. Benzophenone oxime
   11. Nitration of salicylic acid
   12. Preparation of picric acid
   13. Preparation of O-chlorobenzoic acid from O-chlorotolune
   14. Preparation of cyclohexanone from cyclohexanol
2. Identification of organic compounds belonging to the following classes by :
   Systematic qualitative organic analysis including preparation of derivatives Phenols, amides, carbo- hydrates, amines, carboxylic acids, aldehyde and ketones, Alcohols, esters, hydrocarbons, anilides, nitrocompounds.
3. Introduction to the use of stereo models:
   Methane, Ethane, Ethylene, Acetylene, Cis alkene, Trans alkene, inversion of configuration.

Scheme of Practical Examination:

Note : Total sessional marks is 30 (20 for practical sessional plus 10 marks for regularity, promptness, viva-voce and record maintenance).