Qualification: 
Ph.D, MSc, BSc
Email: 
k_elango@cb.amrita.edu

Dr. Elango K. currently serves as Assistant Professor (Sr. Gr)  at the department of Sciences, Amrita School of Engineering, Coimbatore.

After completion of M.Sc in Inorganic Chemistry from University of Madras (2004), pursued his Ph.D (2009) with Dr. G. Anantharaman in Indian Institute of Technology Kanpur and subsequently did post-doctoral research (2011) with Prof. Diemar Stalke  in George August University, Goettingen, Germany.

Affiliation(s)

  • Assistant Professor (SG)

Qualification

Year Degree/Program Institution
2009 Ph. D. IIT Kanpur
2004 M. Sc. University of Madras

Awards, Certificates, Honors and Societies

  1. Received Fast Track Young Scientist award from SERB-DST
  2. Received best oral presentation award in Recent Advances in Metallorganic Chemistry (RAMC-2008) at Periyar University, Salem, India (2008)
  3. Received best poster award in Modern Trends in Inorganic Chemistry XII (MTIC XII) at IITM, Chennai, India (2007)
  4. Qualified Senior Research Fellowship from Indian Institute of Technology Kanpur, India (2006-2009)
  5. Qualified Junior Research Fellowship from Indian Institute of Technology Kanpur, India (2004-2006)
  6. Qualified in Graduate Aptitude Test in Engineering (GATE) in 2004
  7. Received medal and merit certificate in 2004 for first rank in M.Sc Inorganic Chemistry
  8. Received A. L. Mudaliyar Endowment scholarship in 2003 for best performance in M.Sc 1st year

Research interest

  • Area of interest

    • Organic Chemistry - Synthesis of -azolium salts based organocatalysts and their applicationas solvent and catalyst in preparation of bioactive heterocyclic molecules
    • Inorganic Chemistry Chemistry of new ligands: Synthesis and metallation study
    • Material Chemistry – synthesis of -azolium salts based solid state electrolytesandcapped nanoparticle synthes

Research Group

Ph. D.

Anjitha Satheesh
Development of Organocatalysts for synthesis of bioactive heteocyclicmolecules

Kumaresan P.
Synthesis halometallates as recoverable catalysts for organic transformations

Gayathri Krishnan
Development of -azolium salts immobilised and impregnated in solid state

Integrated M. Sc. and M. Sc. Project

Arya Devi
Electrochemistry
 

Ashfana
Protein Fluorescence
 

Nitheesha S.
Chlorometallates based Catalysts

Amritha Radhakrishnan
Catalysis
 

Poornima Ratheesh
Protein fluroscence
 

Namitha Menon
Synthesis of -azolium capped nanoparticles

Anjali Bharathan
Electrochemistry

Saranya C. T.
Electrochemistry

Integrated M. Sc. and M. Sc. Project

Geethu Puthukkudy
An efficient strategy to synthesis of β-carbonyl compounds by 1-pentyl-1,2,4-trizolium methanesulfonate



 

Anjitha Satheesh
Penetration enhancer accelerated solubilization of curcumin by poly (vinylpyrrolidone)
Current Affiliation: Ph. D. Student in department of Sciences, Amrita VishwaVidypeetham

Sreedevi P.
Catalytic reduction of aldehyde and ketone by nabh4 in presence of 1-alkyl-1,2,4-triazolium salts
Current Affiliation – Research assistant, Qatar University
 

Gayathri Krishnan
1-Butyl-1,2,4-triazolium trihaloacetate based organocatalyst triggered solvent free synthesis of dihydropyranopyrazole
Current Affiliation: PhD Student in department of Sciences, Amrita VishwaVidypeetham

Gopika G.
Effect of solvents in 1-butyl 1,2,4 triazolium trihaloacetate based organocatalyst triggered synthesis of 2,3 dihydroquinazolin
Current Affiliation – BSc Projects
 

Nirubama
Sonication effect on synthesis of brønsted acidic 1-alkylimidazolium salts.




 

Anaswara Asok
One pot synthesis of 4h-isoxazole-5-ones using 1-propyl-1,2,4-triazolium trichloroacetate as the organocatalyst
 

Sidharth C.
Synthesis of derivatives of 2-(phenylmethylene) malononitrile in the presence of 1-propyl-1, 2, 4-triazolium trichloroacetate

Theres Mary G.
Synthesis of derivatives of 2-(phenylmethylene) malononitrile in the presence of 1-propyl-1, 2, 4-triazolium trichloroacetate

Funded Project

Year Sponsor Title of the project Grant sanctioned Investigators Status
2011 SERB Synthesis of N-alkylImidazolium / benzimidazolium / triazolium based Ionic Liquids and their Application in Organic Transformations as Solvent and Catalyst 18 Lakhs PI Completed

Teaching

  • UG Theory:
    • 18CHY303 Organic Chemistry II
    • 18CHY3143 Inorganic Chemistry III
    • 18CHY315 Basic Spectroscopic Techniques
    • 15CHY334 Industrial Catalysis
    • CHY 259 Instrumental Methods of Analysis
    • 15CHY100 Chemistry
  • PG/Ph.D Theory
    • 18CHY502 Concepts in Inorganic Chemistry
    • 18CHY513 Organic Reaction Mechanism
    • 15CHY601 Physical Methods in Chemistry
    • 18CHY634 Industrial Chemistry
    • 18CHY638 Supramolecular Chemistry
    • SS904 Spectroscopy
    • SS822 Heterocyclic Chemistry
  • UG Labs
    • 18CHY282 Basic Organic Qualitative Lab
    • 18CHY384 Organic Synthesis and Estimation Lab.
    • 18CHY184 Inorganic Quantitative Lab. – Volumetric Analysis
    • 15CHY181 Chemistry Lab
  • PG Labs
    • 18CHY582 Organic Quantitative Analysis Lab.
    • 18CHY681 Organic Qualitative Analysis Lab.
    • 18CHY584 Inorganic Quantitative Analysis Lab.

Publications

Publication Type: Conference Proceedings

Year of Publication Title

2020

R. Ummar, Selvam, S., Chandhana, J. P., Dr. Satheesh Babu T. G., and Dr. Elango K., “Evaluation of fluorescence based quantification of DNA: Influence of an external fluorescent probe”, Materials Today: Proceedings, vol. 33. pp. 2107-2109, 2020.[Abstract]


Much advancement in biological studies has led to the greater understanding of pathological conditions, their diagnosis and treatment modalities. One among them is polymerase chain reaction (PCR) an effective and inexpensive method used in molecular biology for deoxyribose nucleic acid (DNA) amplification. DNA quantification and characterisation is an important step in molecular cloning. Common laboratory techniques like absorption spectrophotometry, spectrofluorometry and real time PCR are used to quantify DNA. Spectrofluorometry is more specific and sensitive than spectrophotometry method. Fluorescence spectroscopy can be used by adding probes to the sample, called fluorescence probing technique. In the present work, animal DNA is extracted from liver tissues initially. The isolated DNA is then treated with certain fluorescence probe, such as methylene blue (MB). This probe can intercalate with DNA conformations and also can be used for quantification of DNA. The interaction studies of MB with DNA gives understanding of the nano-environment of the conformations of DNA. Molecular mechanics calculations are carried out to ascertain the findings from the experimental data.

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2020

S. Paramparambath, Selvam, S., Puthukkudy, G., Satheesh, A., and Dr. Elango K., “An efficient strategy to synthesis of β-carbonyl compounds by 1-pentyl-1,2,4-triazolium methanesulfonate”, Materials Today: Proceedings, vol. 33. pp. 2144-2147, 2020.[Abstract]


It is well known that applying green chemistry aspects for organic reactions would reduce the toxicity of chemicals and it reduces the amount of volatile organic solvents too. Thus we have developed a Bronsted acidic 1-pentyl-1,2–4-triazolium methanesulfonate as a room temperature ionic liquid for organic reactions as reaction medium. The same has been employed as organocatalyst for the synthesis of β-Carbonyl Compounds. The present papers reveal the significance of ionic liquids in optimization of reaction condition in terms of equivalence of reagents, impact of solvents and amount of catalyst, synthesis of library of halogen rich β-carbonyl compounds.

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2020

G. Gopika, Selvam, S., Kumaresan, P., and Dr. Elango K., “Hydrophobic association of sodium cholate with human serum albumin evades protein denaturation induced by urea”, Materials Today: Proceedings, vol. 33. pp. 2167-2169, 2020.[Abstract]


Human Serum Albumin (HSA) is a prominent protein in plasma. Protein binds with different types of ligands such as fatty acids, drugs and surfactants. Interaction of serum albumin and bile salts is studied, due to its important application in drug delivery and biopharmaceuticals. The bile salts are amphibilic molecules, synthesized by liver and undergo aggregation in aqueous media. In the present work, sodium cholate (NaC) is used as model bile salt. The interaction of NaC and HSA is monitored using intrinsic Trp-214 fluorescence. Urea (U) ([U] = 0–9.6 M) is added to the pre-formed HSA-NaC system to study. The association of NaC with Trp 214, which is buried within the hydrophobic core of sub domain IIA (Sudlow site I) of HSA, shows a prominent nature of maintaining the protein in the native conformation and hence there is very minimal change in photophysical properties of HSA-NaC system. The denaturation study carried out on HSA-NaC system by using chemical denaturant urea, shows very minimal change in the photophysical property of Trp 214, up to a 6 M concentration of U. Whereas, from 7.2 to 9.6 M [U] the fluorescence intensity show a decrease along with a 3 nm red shift.

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2020

S. Kumar Senthil, Murugan, P. Kumar, Selvam, S., Chandhana, J. P., Dr. Satheesh Babu T. G., and Dr. Elango K., “Fluorescence spectroscopic analysis of heavy metal induced protein denaturation”, Materials Today: Proceedings, vol. 33. pp. 2328-2330, 2020.[Abstract]


Protein denaturation occurs when the secondary and tertiary structures of protein undergo conformational changes and native state of protein is destroyed. The most common observation of the denaturation phenomenon is either coagulation or precipitation of proteins. Since the denaturation processes are not strong enough to break the peptide bonds, the amino acid sequence is not perturbed and hence the primary structure of proteins is not affected and uncoils itself into a random shape. There are variety of reagents and conditions which can protein denaturation, such as urea, temperature, pH, alcohol, heavy metal, etc. Heavy metal salts present in the vicinity of a protein can induce protein denaturation by disturbing the disulfide bond. Heavy metal salts which induce protein denaturation are usually Hg2+, Pb2+, Ag+,Tl+, Cd2+and other metal ions with high atomic weights. The heavy metal salts usually reacts with a protein forming insoluble metal-protein salt. Salts such as silver nitrate are used to prevent gonorrhea infections in the eyes of new born infants. It is also used in treatment of various infection and wounds. The current work will involve the fluorescence spectroscopic studies on protein denaturation induced by heavy metal salts; as reported by the fluorescence probing technique. For this study, we will use bovine serum albumin (BSA) is chosen as the protein. The fluorescent property of Tryptophan (Trp) moiety of BSA can be utilized for the study. It can be understood that in present of silver salt, there is Trp fluorescence quenching and data reveals the denaturation of BSA.

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2020

K. M. Gayathri, Paramparambath, S., Satheesh, A., Selvam, S., and Dr. Elango K., “Reduction of aldehydes and ketones by NaBH4 in presence of 1-alkyl-1,2,4-triazolium salts”, Materials Today: Proceedings, vol. 33. pp. 2381-2384, 2020.[Abstract]


We have synthesized two ionic liquids namely 1-hexyl-1,2,4-triazolium methanesulfonate and 1-hexyl-1,2,4-triazolium trifluoroacetate. We have carried out the reduction of various aldehydes and ketones by NaBH4 in the presence of the synthesized ionic liquids. Cinnamaldehyde and acetophenone are used for the optimization of the reaction condition. Reduction of different aldehydes and ketones were carried out and a good yield of product is obtained where the ionic liquid with anion methanesulfonate is used. In the case of ketones, ionic liquid 1-hexyl-1,2,4-triazolium trifluoroactetate gives a good yield.

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2019

C. K. Athira, Manikandan, P., Dr. Elango K., and Ramani, P., “Ionic liquid mediated synthesis of labelled peptide nucleic acid monomer”, Materials Today: Proceedings, vol. 18. pp. 1735-1739, 2019.[Abstract]


We have designed and synthesized phthalimido labelled peptide nucleic acid (PNA) monomer through N-alkylation of α-amino acid ester with N-bromo ethylphthalimide which was facilitated by using ionic liquids. The alkylated product was condensed with nucleobase such as thymine-1-acetic acid to get the target compound. The labelled-PNA monomer is a new molecule which bears a marker and can be easily prepared in two steps

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Publication Type: Journal Article

Year of Publication Title

2019

A. S, P, S., Dr. Elango K., and J, S. S., “Penetration enhancer accelerated solubilization of curcumin by poly(vinylpyrrolidone), ”, Indian Chem.Soc, vol. 96, no. 14, 2019.

2019

T. Shaikh, Nagarajan, S., and Dr. Elango K., “One Pot Multicomponent Biginelli Reaction Employing Ionic Liquids as an Organocatalyst”, Current Organocatalysis, vol. 06, 2019.[Abstract]


Introduction The N-heterocyclic compounds have been extensively studied in pharmaceutical industries. Furthermore, syntheses of such compounds employing organo-catalyst have been associated with sustainable technology. Methods The synthesis of new, stable ionic liquids and their catalytic applications in one-pot multicomponent Biginelli reaction is presented. The method provides broad substrate scope, yielding the corresponding 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, in good to excellent yields, respectively. Results and Conclusion The developed reactions are associated with certain advantages, short reaction time and sustainable conditions. The protocol has advantages eco-friendly procedure, recovery and reusability of catalyst, which showed consistent activity.

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2018

Dr. Elango K., Nagarajan, S., and Shaikh, T. M., “Knoevenagel Reaction Catalyzed by a Reusable Bronsted Acid Based on 1-Alkyl-1,2,4-triazolium Tetrafluoroborate”, Letters in Organic Chemistry, vol. 15, no. 2, 2018.[Abstract]


The Knoevenagel reaction is one of the most useful methods for the synthesis of α,β-unsaturated nitriles. We disclose an efficient protocol for the Knoevenagel reaction of aldehydes withmalononitrile catalyzed by 1-alkyl-1,2,4-triazolium salts to afford the corresponding products in excellentyields. The important feature of this reaction is the catalyst; 1-alkyl-1,2,4-triazolium salts are recycledand reused. Furthermore, the reaction conditions are environment friendly and do not produce anyhazardous waste.

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2018

G. Puthukkudy, Nagarajan, S., and Dr. Elango K., “Brønsted acidic 1-ethyl-1,2,4-trizolium phenylsulfonate as catalyst for biginelli reaction”, Asian Journal of Chemistry, vol. 30, pp. 1999-2002, 2018.[Abstract]


A Brønsted acidic 1-ethyl-1,2,4-triazolium phenylsulfonate has been synthesized and characterized. A catalytic study is performed for 1-ethyl-1,2,4-triazolium phenylsulfonate as acid catalyst for a multicomponent reaction of synthesis of series of 3,4-dihydropyrimidin-2(1H)-ones/thiones and their derivatives have been employed and the results were discussed in detail. © 2018 Chemical Publishing Co. All Rights Reserved.

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2015

Dr. Elango K., “Synthesis and Crystal Structure of (3,5-Me2-Py)2Zn(S-iPr)2: A precursor for ZnS”, Int. J. ChemTech , vol. 8, no. 2, 2015.

2015

J. Porkodiand and Dr. Elango K., “Synthesis and characterization of neoteric green solvent 1-benzylimidazolium cation based brønsted acidic ionic liquids”, Int. J. ChemTech, vol. 8, no. 2, 2015.

2015

J. Porkodi, Nagarajan, S., and Dr. Elango K., “Recyclable 1-isopropylimidazolium trifluoroacetate prompted synthesis of β-carbonyl compounds”, Der Pharma Chemica, vol. 7, no. 6, 2015.

2015

S. Nagarajan, SHAIKH, T. A. N. V. E. E. R. M., and Dr. Elango K., “Synthesis of 1-alkyl triazolium triflate room temperature ionic liquids and their catalytic studies in multi-component Biginelli reaction”, vol. 127, no. 9, pp. 1539 - 1545, 2015.[Abstract]


Synthesis of three Brnsted acid-based ionic liquids, namely, 1-ethyl-1,2,4-triazolium triflate (1a), 1-propyl-1,2,4-triazolium triflate (1b) and 1-butyl-1,2,4-triazolium triflate (1c), is described. These ionic liquids have been employed as catalysts for convenient and high-yielding one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, which are Biginelli reaction products. Advantages of the methodology are operational convenience, short reaction times, avoidance of chromatographic purification and non-production of toxic waste. Further, the catalysts are easily recovered and reused without any noticeable diminution in their catalytic activity.

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2015

S. Nagarajan, Shaikh, T. Mahamadali, and Dr. Elango K., “An ionic liquid catalyzed reusable protocol for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one under mild conditions”, New J. Chem., vol. 39, pp. 9693-9699, 2015.[Abstract]


An efficient protocol has been developed for the synthesis of 2,3-dihydroquinazolinone compounds from anthranilamide and aldehydes or ketones via ionic liquid catalyzed cyclization reaction. The reaction features high efficiency, shorter reaction duration, mild reaction conditions and inexpensive reagents. The catalyst was recovered and reused. The recyclability of ionic liquid resulted in excellent yields of products without loss of any catalytic activity.

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2014

Dr. Elango K., “Synthesis and Crystal Structure of 1-Methyl-3-(2-pyridyl)imidazolium Hexafluorophosphate”, Journal of Crystallography, vol. 2014, p. 219828, 2014.[Abstract]


Compound 1-Methyl-3-(2-pyridyl)imidazolium hexafluorophosphate was crystallized in monoclinic system with space group P21/c and unit cell parameters a=7.3740(8) Å, b=15.5931(16) Å, c=10.4787(11) Å, β= 105.3102°, and  ν=1162.12Å3. The obtained solid state structure of 1-Methyl-3-(2-pyridyl)imidazolium hexafluorophosphate shows CH⋯F type weak interactions and was analyzed.

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2014

S. Nagarajan and Dr. Elango K., “Reusable 1,2,4-Triazolium Based Brønsted Acidic Room Temperature Ionic Liquids as Catalyst for Mannich Base Reaction”, Catalysis Letters, vol. 144, no. 9, pp. 1507 - 1514, 2014.[Abstract]


Unprecedented examples of 1-alkyl-1,2,4-triazolium methanesulfonate based Brønsted acidic room temperature ionic liquids were synthesized and characterized. Their catalytic activity and efficiency in recyclability and reusability on one pot synthesis of halide substituted β-amino carbonyl compounds are reported.

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2013

Dr. Elango K., “Synthesis and Crystal structure of diacetato-bis(2-methyl-2-propylamine)zinc(II)”, Journal of Structural Chemistry volume, vol. 54, no. 1, pp. 177 - 181, 2013.[Abstract]


The diacetato-bis(2-methyl-2-propylamine)zinc(II) compound crystallizes in the triclinic system, space group P-1 with unit cell parameters a = 10.0144(10)Å, b = 10.2687(10)Å, c = 10.5149(10)Å. α = 115.184(2)°, β = 97.489(2)°, γ = 114.066(2)°, ν = 830.85(14)Å3. The obtained solid state structure of (tBuNH2)2Zn(OOCCH3)2 shows both inter- and intramolecular NH—O hydrogen bond interactions which are analyzed.

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2012

Dr. Elango K., “Synthesis and Crystal Structure of 1,3-Dimesitylimidazolium 2,4,6-Triflurophenolate·2,4,6-Triflurophenol”, Molecular Crystals and Liquid Crystals, vol. 557, pp. 262-267, 2012.[Abstract]


{ The basicity of 1,3-dimesitylimidazol-2-ylidene was verified by treating with two equivalent of 2,4,6-triflurophenol. The resulted compound 1,3-dimesitylimidazolium 2,4,6-triflurophenolate·2,4,6-triflurophenol (1) was crystallized in monoclinic centrosymmetric space group P21/c with unit cell parameters a = 7.9597(11) Å

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2007

G. Anantharamanand and Dr. Elango K., “Synthesis and Structural Characterization of NHC-supported Zinc aryloxide and Zinc Hydroxyaryloxide ”, Organometallics, vol. 26, pp. 1089-1092, 2007.

2007

G. Anantharaman and Dr. Elango K., “Synthesis of Imidazolium/Benzimidazolium Salts and the Preparation of Silver(I) Complex of Bis‐Benzimidazolium Dibromide”, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, vol. 37, pp. 719-723, 2007.[Abstract]


The reactions of N‐methyl imidazole with benzyl bromide and N‐isopropyl benzimidazole with either benzyl bromide or 2,4,6‐trimethyl benzyl bromide afforded the expected imidazolium/benzimidazolium salts, respectively. However, the reaction of N‐methyl imidazole/N‐isopropyl benzimidazole with tert‐butyl bromide results in an unexpected 1‐methyl imidazolium/benzimidazolium bromide. The latter products show a very low melting point without decomposition which suggests that they belong to the category of ionic liquids. Further, the treatment of N‐isopropyl imidazole/N‐isopropyl benzimidazole with 1,3‐bis(bromomethyl)‐2,4,6‐trimethylbenzene yielded 1,1′‐di(isopropyl)‐3,3′‐(mesityldimethylene)‐diimidazolium/dibenzimidazolium dibromide. In this paper, the syntheses and the spectroscopic characterizations of all the seven imidazolium/benzimidazolium salts and the synthesis of silver(I) complex of 1,1′‐di(isopropyl)‐3,3′‐(mesityldimethylene)‐dibenzimidazolium dibromide are reported.

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2007

Dr. Elango K., Srirambalaji, R., and Anantharaman, G., “Synthesis of N-alkylimidazolium salts and their utility as solvents in the Beckmann rearrangement”, Tetrahedron Letters, vol. 48, pp. 9059-9062, 2007.[Abstract]


Six different room temperature ionic liquids (RTILs) based on N-methyl or N-isopropyl imidazolium cations with counteranions, such as BF4-, PF6-, and OTf−, have been synthesized by exchanging the counteranions of the corresponding N-methyl or N-isopropylimidazolium bromides using appropriate salts such as NH4BF4, KPF6, and AgOTf. Catalytic amounts of these ionic liquids (ILs) have been used as the reaction medium for the Beckmann rearrangement of oximes to amides in the presence of PCl5. A moderate to good conversion of oximes to amides in all the six ILs was observed.

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Invited Talks

  1. Elango , 2nd International conference on science & technology, engineering and management (I-STEM), Kumaraguru college of technology on 15th FEB 2019, presented lecture on chemistry of ionic liquids.
  2. Elango “Refresher course on Chemistry”, held at UGC-Human Resource Development Centre, Bharathidasan University, Kajahmalai Campus from 28th Jan to 17th Feb 2015, Trichy, presented a titled” Ionic Liquids – A Green path”
  3. Elango “12th International Symposium on Inorganic Ring Systems” (IRIS-12) held at Goa, India (2009), August. 16-21 and presented a oral lecture titled “Synthesis, Structural Characterization and Reactivity of Zinc Aryloxides Adducts”
  4. Elango “Recent Advances in Metallorganic Chemistry” (RAMC-2008) held at Periyar University, Salem, India (2008), Oct. 16-17 and presented a oral presentation titled “Synthesis and hydrolysis of NHC stabilized zinc aryloxides”

Membership and Professional Responsibility

  1. Life Member in “Chemical Research Society of India (CRSI)”
  2. Acted as session chairperson in I-STEM 2018 and I-STEM 2019.
  3. Member “Board of study” in Engineering chemistry and Environmental Sciences
  4. Member “Board of study” in Int.MSc and MSc chemistry in amrita vishwa vidyapeetham
  5. Editorial board member in International Journal of Chemical Engineering Research (IJChER)
  6. Treasurer for Chemical society, IIT Kanpur – 2008-2009
  7. Member organizing committee for “Recent Trends in Applied Chemistry (RTAC-2013)” held at Vel Tech University, Aug 31,2013
  8. Programme coordinator for “INSPIRE Internship Science Camp” held at Vel Tech University, July,2014
Faculty Research Interest: