Publication Type : Conference Proceedings
Publisher : Materials Today: Proceedings
Source : Materials Today: Proceedings, Volume 18, p.1735-1739 (2019)
Url : https://www.sciencedirect.com/science/article/pii/S2214785319311174
Keywords : alkylation, Ionic liquids, peptide nucleic acids, Phthalimides
Campus : Coimbatore
School : School of Engineering
Department : Sciences
Year : 2019
Abstract : We have designed and synthesized phthalimido labelled peptide nucleic acid (PNA) monomer through N-alkylation of α-amino acid ester with N-bromo ethylphthalimide which was facilitated by using ionic liquids. The alkylated product was condensed with nucleobase such as thymine-1-acetic acid to get the target compound. The labelled-PNA monomer is a new molecule which bears a marker and can be easily prepared in two steps
Cite this Research Publication : C. K. Athira, Manikandan, P., Dr. Elango K., and Ramani, P., “Ionic liquid mediated synthesis of labelled peptide nucleic acid monomer”, Materials Today: Proceedings, vol. 18. pp. 1735-1739, 2019.