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A Systems Model of Parkinson’s Disease Using Biochemical Systems Theory

Publication Type : Journal Article

Thematic Areas : Biotech, Learning-Technologies

Publisher : OMICS: A Journal of Integrative Biology .

Source : OMICS: A Journal of Integrative Biology 2017, Vol. 21 No. 8 , 454 - 464.

Url : https://doi.org/10.1089/omi.2017.0056

Campus : Amritapuri

School : School of Biotechnology

Center : Amrita Mind Brain Center, Biotechnology, Computational Neuroscience and Neurophysiology

Department : biotechnology

Year : 2017

Abstract : Parkinson's disease (PD), a neurodegenerative disorder, affects millions of people and has gained attention because of its clinical roles affecting behaviors related to motor and nonmotor symptoms. Although studies on PD from various aspects are becoming popular, few rely on predictive systems modeling approaches. Using Biochemical Systems Theory (BST), this article attempts to model and characterize dopaminergic cell death and understand pathophysiology of progression of PD. PD pathways were modeled using stochastic differential equations incorporating law of mass action, and initial concentrations for the modeled proteins were obtained from literature. Simulations suggest that dopamine levels were reduced significantly due to an increase in dopaminergic quinones and 3,4-dihydroxyphenylacetaldehyde (DOPAL) relating to imbalances compared to control during PD progression. Associating to clinically observed PD-related cell death, simulations show abnormal parkin and reactive oxygen species levels with an increase in neurofibrillary tangles. While relating molecular mechanistic roles, the BST modeling helps predicting dopaminergic cell death processes involved in the progression of PD and provides a predictive understanding of neuronal dysfunction for translational neuroscience.

Cite this Research Publication : Sasidharakurup H, Melethadathil N, Nair B, Diwakar S. "A Systems Model of Parkinson's Disease Using Biochemical Systems Theory", OMICS: A Journal of Integrative Biology 2017, Vol. 21 No. 8 , 454 - 464.

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