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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Eur J Pharm Sci
Source : Eur J Pharm Sci, Volume 96, p.193-206 (2017)
Url : http://www.sciencedirect.com/science/article/pii/S0928098716303591
Keywords : Administration, Cutaneous, Animals, Anti-Inflammatory Agents, Cell Line, chitin, Clobetasol, Drug Carriers, Humans, Mice, Mice, Inbred BALB C, Nanogels, Organ Culture Techniques, Polyethylene glycols, polyethyleneimine, psoriasis, Skin Absorption, Skin Cream, Swine
Campus : Kochi
School : Center for Nanosciences, School of Pharmacy
Center : Nanosciences
Department : Pharmacology
Verified : No
Year : 2017
Abstract : pIn the present study chitin nanogel loaded with anti-psoriatic drug clobetasol was developed (CLCNG) for its topical delivery in psoriasis. CLCNG had the particle size of 132±14nm, with gel like consistency, stability in refrigerator, having higher drug release properties at acidic pH. CLCNG exhibited significant toxicity towards HaCaT and THP-1cell lines by MTT assay. The uptake of nanogel by HaCaT cell lines was confirmed by fluorescent microscopy. CLCNG at 0.35mg/ml exhibited significant anti-inflammatory activity with an average of 65% and 70% inhibition in COX and LOX activities expressed in THP-1 cells. In vitro skin permeation studies revealed the increased transdermal flux with fragmented stratum corneum and loosened epidermal layers in CLCNG treated samples, compared with control drug solution. The in vivo anti-psoriatic studies done on imiquimod model confirmed the potential benefits of the nanogel for the topical delivery of clobetasol in psoriasis./p
Cite this Research Publication : R. Panonnummal, Jayakumar, R., and Sabitha, M., “Comparative anti-psoriatic efficacy studies of clobetasol loaded chitin nanogel and marketed cream.”, Eur J Pharm Sci, vol. 96, pp. 193-206, 2017.