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Publication Type : Journal Article
Publisher : Wiley
Source : Applied Organometallic Chemistry, 2011
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2011
Abstract : A mild and rapid one-pot process for Reformatsky and Barbier reactions using a catalytic quantity of zirconocene dichloride (Cp2ZrCl2) as a promoter and zinc as a terminal reductant at room temperature in dimethyl formamide was developed. The protocol has wide substrate suitability and afforded the desired 3-substituted-3-hydroxyindolin-2-ones from istains in good yields and short reaction time.
Cite this Research Publication : Mangilal Chouhan, Ratnesh Sharma and Vipin A. Nair, "Cp2ZrCl2-induced Reformatsky and Barbier reactions on isatins: an efficient synthesis of 3-substituted-3-hydroxyindolin-2-ones", Applied Organometallic Chemistry, 2011, 25, 305-309.