Course

Unit 1

Basics of Biosensors and Nanobiosensors: Biosensor and Its Working Principle; Characteristics of a Biosensor; Biosensor Evolution: A Brief Outlook; Types of Biosensors; On the Basis of the Use of Biorecognition Elements: Catalytic Versus Affinity Biosensors; Application of Biosensors

Unit 2

Transduction Process-Based Classification of Biosensors: Electrochemical Biosensors; Optical Biosensors; Mass-Based Biosensors; Thermal Biosensors; Energy Biosensors; Fabrication and testing. Comparison of bulk and nano effects in sensing

Unit 3

Novel Nanomaterials for Biosensor Development: Graphene and Its Composites; Carbon Nanotubes and Their Hybrids; Nitride-Based Biosensors; Metal and Metal Oxide; Nanoparticles for Biosensors

Unit 4

Biomarkers and Their Role in Detection of Biomolecules: Types of Biomarkers; Cancer Biomarker; Cardiac Biomarkers; Biomarker of Aging; Alzheimer’s Biomarker; HIV Biomarker; Nanobiosensors for Point-of-Care Medical Diagnostics

Unit 5

Other Applications of nanobiosensors: Use of Biosensors for Mycotoxins Analysis in Food Stuff; Development of Biosensors for Drug Detection Applications; Detecting the Presence of Illicit Drugs; Determination of Pesticides and Their Residues; Smartphone-Based Biosensors 

Pre-requisites: Basic math, physics, chemistry and biology

Total number of classes: 45

Course Outcomes:

• To understand the fundamentals of sensing devices.
• To develop an understanding about the various components of a sensor and its fabrication.
• To comprehend the mechanisms of sensing.
• To understand the classifications of sensors/nanosensors based on the mechanism used.
• Recent advances in sensors and how nanotechnology facilitates easier sensing.

Course Outcomes:

CO 1 – To understand the fundamentals of sensing devices.

CO 2 – To develop an understanding about the various components of a sensor and its fabrication.

CO 3 – To comprehend the mechanisms of sensing.

CO 4 – To understand the classifications of sensors/nanosensors based on the mechanism used.

CO 5 – Recent advances in sensors and how nanotechnology facilitates easier sensing.

PROGRAM OUTCOME:

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

MAPPING (CO/PO)

0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity

PROGRAM SPECIFIC OUTCOMES (PSO):

PSO1: Mastery of Nanomaterial Science and Characterization

PSO2: Understanding of Cellular and Molecular Systems

PSO3: Application of Nanobiotech in Diagnostics and Therapy

PSO4: Experimental Design and Data Analysis

PSO5: Research Competency and Methodological Rigor

PSO6: Industry and Career Readiness

MAPPING (CO/PSO)

Textbooks:

1. Nanobiosensors from Design to Applications, Edited by Aiguo Wu and Waheed S Khan, Wiley-VCH, 2020
2. Nanobiosensors for Point-of-Care Medical Diagnostics, Editors: Manashjit Gogoi, Sanjukta Patra, Debasree Kundu, Springer 2022
3. Nanosensors for Chemical and Biological Applications: Sensing with Nanotubes, Nanowires and Nanoparticles, Edited by: Kevin C. Honeychurch, Woodhead Publishing Limited, 2014.
4. Jacob Frade, “Handbook of Modern Sensors: Physics, Designs and Application,” Fourth Edition, Springer, 2004
5. Brian R. Eggins, “Chemical Sensors and Biosensors”, John Wiley and Sons, 2002

References:

1. Vinodh Kumar Khanna, “Nanosensors Physical, Chemical, And Biological,” CRC Press 2012
2. Florinel-Gabriel Banica, “Chemical sensors and biosensors: Fundamentals and Applications,” John Wiley & Sons, 2002.