Dr. Kaladhar Kamalasanan joined as Assistant Professor in the Department of Pharmaceutics, Amrita School of Pharmacy in September 2015. He has 12 years research experience. He has last served as Fellow Scientist –D at Sree Chitra Tirunal Institute for Medical Sciences and Technology, India and is currently consulting for various organizations nationally and internationally.

He has more than three years of post doctoral research experience in USA from one of premier research groups in immunotherapeutics and drug delivery, Mc Gowan Institute for Regenerative Medicine; Department of Chemical Engineering, Bioengineering & Immunology, University of Pittsburgh, USA as well as he was a visiting scholar to Phillipps University, Marburg in Germany for 2 years.

He has completed Ph. D. in Biomedical Engineering (Biosurface Modification), Biomedical Technology Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology. He has also done his M. Pharm. at Annamali University, Tamil Nadu and Bachelor of Pharmacy at Dr. MGR University, Tamil Nadu.

He has developed products filed several national and international patents, bagged several awards and has several research articles, book chapters and conference proceedings. He also actively participate in various professional society activities.

SELECTED LIST OF

Publications

Publication Type: Journal Article
Year of Publication Publication Type Title
2014 Journal Article K. Kamalasanan, Renz, H., and Sharma, C. P., “Cell-mimetic coatings for immune spheres”, Colloids and Surfaces B: Biointerfaces, vol. 123, pp. 845–851, 2014.[Abstract]

Extrinsically induced or engineered cells are providing new therapeutic means in emerging fields such as cell therapeutics, immunomodulation and regenerative medicine. We are demonstrating a spatial induction method using lipid coatings, which can change signal presentation strength from material surface to adherent macrophage cells, that induce early cell–cell interaction leading to organotypic morphology. For that, we have developed a cell mimetic lipid coating with a rafts size to the order of transmembrane proteins (<10 nm) with enhanced lateral elastic properties. Such surface coatings are capable of reducing adherent macrophage spreading, while enabling early induction of cell–cell interaction to form organotypic macrophage colonies or “spheres” (M-spheres).

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2013 Journal Article K. Kamalasanan, Gottardi, R., Tan, S., Chen, Y., Godugu, B., Rothstein, S., Balazs, A. C., Star, A., and Little, S. R., ““Zero-Dimensional” Single-Walled Carbon Nanotubes”, Angewandte Chemie International Edition, vol. 52, no. 43, pp. 11308–11312, 2013.[Abstract]

The shorter, the more dispersible: An iterative, emulsion-based shortening technique has been used to reduce the length of single-walled carbon nanotubes (SWNTs) to the same order of magnitude as their diameter (ca. 1 nm), thus achieving an effectively “zero-dimensional” structure with improved dispersibility and, after hydroxylation, long-term water solubility. Finally, zero-dimensional SWNTs were positively identified using mass spectrometry for the first time.

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2011 Journal Article K. Kamalasanan, Jhunjhunwala, S., Wu, J., Swanson, A., Gao, D., and Little, S. R., “Patchy, Anisotropic Microspheres with Soft Protein Islets”, Angewandte Chemie International Edition, vol. 50, no. 37, pp. 8706–8708, 2011.[Abstract]

Useful contacts: A new method to achieve regular patterns generates anisotropic, “patchy” microspheres by using interfacial condensation of a liquid mask and the proximity of the particles to their neighbors to determine a mask pattern. The microspheres are separated from the scaffold and labeled with a first protein at non-mask regions (green) followed by removal of the mask and immobilization of a second protein (red).

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2004 Journal Article S. C. Basak, Kamalasanan, K., and Subburaj, T., “Doxycycline hyclate delayed release capsules with sodium starch glycolate as a pH-dependent pore forming agent”, Indian journal of pharmaceutical sciences, vol. 66, pp. 704–707, 2004.[Abstract]

Delayed release doxycycline hyclate capsules were prepared with suitable blend of doxycycline hyclate-coated nonpareil seed pellets and doxycycline hyclate delayed release pellets. The delayed release pellets were prepared by coating the doxycycline hyclate-coated pellets with hydroxypropylmethylcellulose phthalate-55 polymer solution. A concentration of polymer in the range of 15 to 20% was found to comply with drug release test as specified in the USP in acid medium but failed to meet the requirements in buffer medium (pH 5.5). The inclusion of sodium starch glycolate (1-3%) in both doxycycline-coated and delayed release pellets preparation stages was found to enhance the release of the drug in the buffer medium without altering its release in acid medium. The blend of delayed release pellets (75%) and drug-coated pellets (25%) in delayed release doxycycline hyclate capsules produced an optimum in vitro drug release in both the media.

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Faculty Details

Qualification:

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Faculty Email: 
kaladhar22654@aims.amrita.edu