Publication Type : Journal Article
Publisher : Elsevier
Source : Colloids and Surfaces B: Biointerfaces, vol. 123, pp. 845–851, 2014.
Url : http://www.sciencedirect.com/science/article/pii/S092777651400576
Keywords : Biomaterials, Colloids, Lipids, macrophage, Surface coating
Campus : Kochi
School : School of Pharmacy
Center : Amrita Institute of Medical Science
Department : Pharmaceutics
Verified : Yes
Year : 2014
Abstract : Extrinsically induced or engineered cells are providing new therapeutic means in emerging fields such as cell therapeutics, immunomodulation and regenerative medicine. We are demonstrating a spatial induction method using lipid coatings, which can change signal presentation strength from material surface to adherent macrophage cells, that induce early cell–cell interaction leading to organotypic morphology. For that, we have developed a cell mimetic lipid coating with a rafts size to the order of transmembrane proteins (10 nm) with enhanced lateral elastic properties. Such surface coatings are capable of reducing adherent macrophage spreading, while enabling early induction of cell–cell interaction to form organotypic macrophage colonies or “spheres” (M-spheres).
Cite this Research Publication : Dr. Kaladhar Kamalasanan, Renz, H., and Sharma, C. P., “Cell-mimetic coatings for immune spheres”, Colloids and Surfaces B: Biointerfaces, vol. 123, pp. 845–851, 2014.