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Dr. Krishnakumar Menon

Associate Professor

Dr. Krishnakumar Menon is an Associate Professor at Amrita Centre for Nanosciences and Molecular Medicine (ACNSMM) and currently heads the Clinical Proteomics and Translational Research Laboratory.

Qualification: Ph.D
krishnakumarmenon@aims.amrita.edu

Bio

Dr. Krishnakumar Menon is an Associate Professor at Amrita Centre for Nanosciences and Molecular Medicine (ACNSMM) and currently heads the Clinical Proteomics and Translational Research Laboratory. Dr. Menon obtained M. Sc. in Biochemistry from Department of Biochemistry, M. S. University of Baroda, India and M. Sc.-Ph. D. on a scholarship equivalent to commonwealth research grant from National Multiple Sclerosis (MS) Society of Australia at Monash-La Trobe University, Australia. He is a recipient of student honor from La Trobe University and the prestigious JSPS fellowship from Japanese government to carry out oligosaccharide changes associated with myelin forming cells at the National Institute for Physiological Sciences, Japan. Subsequently, he was a fellow at the University of Connecticut Health Center, USA, as Research Investigator and Assistant Research Scientist at the University of Iowa hospitals, USA and the Monash Immunology and Stem Cell Laboratories at Monash University, Australia before joining as an Associate Professor at ACNSMM.  Dr. Menon’s main objective is to diagnose MS early and develop therapies for treating MS. In this respect, Dr. Menon developed different techniques for identifying novel biomarkers of diagnostic, prognostic and therapeutic significance in MS. His laboratory is supported by different grants from ICMR, DBT including Indo- Australian and Novartis global research grants. Currently, the lab’s focus is to take their research findings to the clinic for the benefit of patients.

Publications

Journal Article

Poly (Lactic Acid)-chitosan-Collagen Composite Nanofibers as Substrates for Blood Outgrowth Endothelial Cells

Authors : Dr. Krishnakumar Menon, Swarnalatha, B; Nair, S.L.; b c , Shalumon, K.T.a ,; Paul-Prasanth, B;Hebbel, R.P.; Somani, A; Nair, S.V.; Milbauer, L.C.; Jayakumar, R

Publisher : International Journal of Biological Macromolecules

A Novel Unbiased Proteomic Approach to Detect the Reactivity of Cerebrospinal Fluid in Neurological Diseases

Authors : Dr. Krishnakumar Menon, Steer, D.L; Short, M; Petratos, S; Smith, I; Bernard, C.C.A

Publisher : Molecular and Cellular Proteomics

Development and molecular characterization of polymeric micro-nanofibrous scaffold of a defined 3-D niche for in vitro chemosensitivity analysis against acute myeloid leukemia cells

Authors : Dr. Deepthy Menon, Dr. Krishnakumar Menon, Prof. Shantikumar Nair, M. G. Sangeetha Nair; Dr. Ullas Mony;Dr. Manzoor K.; N Sidharthan; Keechilat Pavithran; Shantikumar V Nair;

Publisher : International journal of nanomedicine

Genotype–phenotype analysis of von Hippel–Lindau syndrome in fifteen Indian families

Authors : Dr. Krishnakumar Menon, Vikkath, Narendranath; Valiyaveedan, Sindhu; Nampoothiri, Sheela; Radhakrishnan, Natasha; Pillai, Gopal S.; Nair, Vasantha; Ginil Kumar Pooleri; Mathew, Georgie; Ariyannur, Prasanth S.; Pillai, Ashok B.

Publisher : Familial Cancer

Nanotechnology Approaches for Enhanced CNS Delivery in Treating Alzheimer’s Disease

Authors : Sreeja C. Nair, Dr. Krishnakumar Menon, Dr. Sabitha M., M.A. Arya; Maneesha Kalappurackal

Publisher : Journal of Drug Delivery Science and Technology

Analysis of Gene Mutations among South Indian Patients with Maple Syrup Urine Disease: Identification of Four Novel Mutations

Authors : Dr. Krishnakumar Menon, Narayanan, M.P.; Dr. Damodaran Vasudevan;

Publisher : Indian Journal of Geo-Marine Sciences

Understanding the Adhesion Mechanism of Mucin Binding domain from Lactobacillus fermentum and its Role in Enteropathogen Exclusion.

Authors : Dr. Gopi Mohan C., Dr. Krishnakumar Menon, Dr. Raja Biswas, Chatterjee, Maitrayee; Pushkaran, Anju Choorakottayil; Vasudevan, Anil Kumar;

Publisher : Int J Biol Macromol

Rationally Designed Aberrant Kinase-Targeted Endogenous Protein Nanomedicine Against Oncogene Mutated/Amplified Refractory Chronic Myeloid Leukemia

Authors : Dr. Krishnakumar Menon, Retnakumari, A.P.; Hanumanthu, P.L.; Malarvizhi, G.L.; Prabhu, R.; Sidharthan, N.; Thampi, M.V.; Dr. Deepthy Menon; Mony, U.; Keechilat, P.; Nair, S.; Dr. Manzoor K.

Publisher : Molecular Pharmaceutics

Recombinant Expression of Extracellular Domain of Mutant Epidermal Growth Factor Receptor in Prokaryotic and Baculovirus Expression Systems

Authors : Dr. Krishnakumar Menon, Vettath, S.K.; Shivashankar, G.; Dr. Lakshmi Sumitra

Publisher : International Journal of Biological Macromolecules

Significance of Elevated Prohibitin 1 levels in Multiple Sclerosis Patients Lymphocytes towards the Assessment of Subclinical Disease Activity and its role in the Central Nervous System Pathology of Disease.

Authors : Dr. Krishnakumar Menon, Satheesh Kumar, Madathiparambil Kumaran; Nair, Sreepriya; Dr. Ullas Mony; Kalingavarman, Sugavanan; Venkat, Ramaswamynathan; Sivanarayanan, Thanghalazhi Balakrishnan; Unni, Ayalur Kodakara Kochugovindan; Rajeshkannan, Ramiah; Anandakuttan, Anandakumar; Radhakrishnan, Sureshkumar;

Publisher : International Journal of Biological Macromolecules

Molecular Analysis of Oncogene Expressions in Different Grades of Gliomas

Authors : Dr. Krishnakumar Menon, Serene Xavier; Karimassery Ramaiyer Sundaram; Lalitha Biswas; Dilip Panikar; Bindhu Mangalath Rajamma; Nair, S.; Dr. Lakshmi Sumitra

Publisher : Journal of Integrated OMICS

Identification of Prolargin Expression in Articular Cartilage and its Significance in Rheumatoid Arthritis Pathology

Authors : Dr. Krishnakumar Menon, Prof. Shantikumar Nair, Vinod Soman Pillai; Rameshwari R. Kundargi; Fabia Edathadathil; Shantikumar V Nair; Jai Thilak; Roshini Anney Mathew; Tessy Xavier; Padmanabha Shenoy;

Publisher : International Journal of Biological Macromolecules

Expression and Purification of Quinine Dihydro Pteridine Reductase from astrocytes and its significance in the astrocyte pathology

Authors : Dr. Krishnakumar Menon, Prof. Shantikumar Nair, Chandrashekaran, Swathine; Karthikeyan, Srija; Balakrishnan, Arvind; Nair, Sreepriya; Satheesh Kumar, Madathiparambil Kumaran; Vattathara, Jane Jose; Shantikumar V Nair

Publisher : International Journal of Biological Macromolecules

Exploring the Role of Defective Fibronectin Matrix Assembly in the VHL-Associated CNS Hemangioblastoma.

Authors : Dr. Krishnakumar Menon, N. Vikkath, Ariyannur, P., Mr, B., and Pillai, A.

Publisher : Drug Metab Pers Ther

Substrate Specific Inhibitor Designed against the Immunomodulator GMF-beta Reversed the Experimental Autoimmune Encephalomyelitis

Authors : Dr. Gopi Mohan C., Dr. Krishnakumar Menon, Vattathara, J.J., Prakash, O, Subhramanian, S, Satheeshkumar, M.K, Xavier, T, Anil, M, Pillai, G.S, Anandakuttan, A, Radhakrishnan, S, Sivanarayanan, T.B, Unni, A.K.K

Publisher : Scientific Reports

Patents

Compositions and Methods for Autoimmune Disease Treatment Inventors

Authors : Prashant S., Dr. Krishnakumar Menon, Prof. Shantikumar Nair, Bernard, C. C. A., Sadanandan, P., Payne, N. L., and Shantikumar V Nair

Publisher : U.S. Patent Australian Provisional Patent Application no: 2016903294

Invited Lectures
  1. “Biochemical dissection of myelin-axolemmal complexes” Biochemistry and Molecular biology symposium, University of Connecticut, USA. 2002.
  2. “Mechanisms in Immune mediated demyelination” Department of Neurology, University of Iowa, Iowa, USA. 2007.
  3. “Biochemical Mechanisms in Demyelination” Department of Biochemistry, Karnataka University, Dharwad, Karnataka, India. 2007.
  4. “”Molecular Mechanisms Involved in the Breakdown of Myelin: Implication for Neurodegenerative Diseases”. Raman Imaging Workshop, National Center for Biological Sciences, Bangalore, India. 2007.
  5. “Molecular Mechanisms in Immune-mediated Demyelination”. National Brain Research Center, Gurgaon, New Delhi, India. 2007.
  6. “Role of Immune factors in Breakdown of Myelin” Monash Immunology and Stem cell Laboratories, Monash University, Melbourne, Australia. 2008.
  7. “Biochemistry of Myelinolysis” Neural Information Laboratory, National Institute for Physiological Sciences, Okazaki, Japan. 2008.
  8. ” Biochemistry behind demyelination and its implications” (2012). Amrita Institute of Medical Sciences, Kochi.
  9. “Identification of novel molecules of clinical significance in neurodegenerative disease using far-western clinical proteomics”. Bioquest International conference (2013). India.
  10. “Far-western clinical proteomics to identify molecules of importance in different autoimmune diseases”. (2014). National Symposium on Trends in Biochemical Sciences. M.S. University of Baroda. India.
  11. “Identification of prognostic marker for central nervous system leukemia and its significance in leukemia pathogenesis” (2015). Next Gen NextGen Genomics, Biology, Bioinformatics and Technology (NGBT) conference, 1-3rd October, HICC, Hyderabad, India
  12. Invited speaker in Amrita samyogam conference on integrative Ayurveda, held at Amrita Institute of Medical Sciences, Kochi. 6-7, August 2017.
  13. Invited speaker in Biological application on Nanoparticles held at IIT Chennai in Dec 4 and 5th 2017. 14. Invited speaker in ICRIMS held at Kochi in July 2018.
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