Back close

Dr. Manitha B. Nair

Associate Professor, Amrita School of Nanosciences and Molecular Medicine, Kochi

Qualification: Ph.D
manithanair@aims.amrita.edu

Bio

Dr. Manitha B. Nair joined ACNSMM in January 2012. Dr. Manitha has an M.Sc. in Biotechnology from Kerala University (2003) and Ph. D in Bone Tissue Engineering from Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India (2009), post which, she pursued post-doctoral research in Mikos Lab, Rice University, USA, and in Platt Lab, Georgia Institute of Technology, USA. She has also worked at the Max Bergmann Centre for Biomaterials, Technical University of Dresden, Germany, in 2006, as a part of DST-DAAD project (Indo-German personnel exchange programme).

Dr. Manitha has several International journal publications to her credit. She serves as the reviewer of many reputed journals in biomedical research. She has received many prestigious awards throughout her academic career that includes Kerala State Young Scientist Award 2016; MAHE award (2015) for the best scientific paper presented during the Indo-Australian BiTERM Conference; Innovative Young Biotechnology Award (2012) from the Department of Science and Technology, Govt. of India; Young Scientist fellowship of the Department of Science and Technology, Govt. of India (2012); Young Scientist Award (2007); ZEISS Best Photomicrograph Award (2006) in Life Sciences. She is the founder Life Member of Society for Tissue Engineering and Regenerative Medicine, India; Life Member of Materials Research Society of India, and Life member of Indian Society of Nanomedicine.

Dr. Manitha’s research focuses on the development and clinical translation of biomimetic nanomaterials towards musculoskeletal (bone, cartilage, ligament) and intervertebral disc regeneration. She is also interested in investigating the signaling cues that support lineage-specific differentiation of mesenchymal stem cells. In addition, Dr. Manitha’s work is also focused towards improving the release kinetics of antimicrobial agents for osteomyelitis treatment. The role of phytochemicals / growth factors in enhancing tissue regeneration is also being investigated.

 

Publications

Journal Article

Year : 2021

Effect of wheat gluten on improved thermal cross-linking and osteogenesis of hydroxyapatite-gelatin composite scaffolds.

Cite this Research Publication : Lalitha Sri Ramakrishnan, Unnikrishnan Ps, Chinchu K Sabu, Amit G. Krishnan, and Dr. Manitha B. Nair, “Effect of wheat gluten on improved thermal cross-linking and osteogenesis of hydroxyapatite-gelatin composite scaffolds.”, International Journal of Biological Macromolecules, vol. 183, pp. 1200-1209, 2021.

Publisher : International Journal of Biological Macromolecules

Year : 2021

Decellularization and oxidation process of bamboo stem enhance biodegradation and osteogenic differentiation

Cite this Research Publication : A. S. H, Mohan, C. C., P.S, U., Krishnan, A. G., and Dr. Manitha B. Nair, “Decellularization and oxidation process of bamboo stem enhance biodegradation and osteogenic differentiation”, Materials Science and Engineering: C, vol. 119, p. 111500, 2021.

Publisher : Materials Science and Engineering: C

Year : 2020

Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing

Cite this Research Publication : Cherian Aleena Mary, Joseph John, Dr. Manitha B. Nair, Shantikumar V Nair, Maniyal Vijayakumar, and Dr. Deepthy Menon, “Successful Reduction of Neointimal Hyperplasia on Stainless Steel Coronary Stents by Titania Nanotexturing”, ACS OmegaACS Omega, vol. 5, no. 28, pp. 17582 - 17591, 2020.

Publisher : ACS OmegaACS Omega, American Chemical Society,

Year : 2020

Biodegradable nanocomposite fibrous scaffold mediated local delivery of vancomycin for the treatment of MRSA infected experimental osteomyelitis.

Cite this Research Publication : Krishnan Amit G, Dr. Raja Biswas, Dr. Deepthy Menon, and Dr. Manitha B. Nair, “Biodegradable nanocomposite fibrous scaffold mediated local delivery of vancomycin for the treatment of MRSA infected experimental osteomyelitis.”, Biomater Sci, vol. 8, no. 9, pp. 2653-2665, 2020.

Publisher : Biomater Sci

Year : 2020

Bioinspired Nanocomposite Fibrous Scaffold Mediated Delivery of ONO-1301 and BMP2 Enhance Bone Regeneration in Critical Sized Defect

Cite this Research Publication : S. Kuttappan, Jo, J. -ichiro, Sabu, C. K., Dr. Deepthy Menon, Tabata, Y., and Dr. Manitha B. Nair, “Bioinspired Nanocomposite Fibrous Scaffold Mediated Delivery of ONO-1301 and BMP2 Enhance Bone Regeneration in Critical Sized Defect”, Materials Science and Engineering: C, vol. 110, p. 110591, 2020.

Publisher : Materials Science and Engineering: C

Year : 2020

ONO-1301 Loaded Nanocomposite Scaffolds Modulate cAMP Mediated Signaling and Induce New bone Formation in Critical Sized Bone Defect

Cite this Research Publication : S. Kuttappan, Jo, J. - I., Dr. Deepthy Menon, Ishimoto, T., Nakano, T., Shantikumar V Nair, Tabata, Y., and Dr. Manitha B. Nair, “ONO-1301 Loaded Nanocomposite Scaffolds Modulate cAMP Mediated Signaling and Induce New bone Formation in Critical Sized Bone Defect”, Biomater. Sci., vol. 8, pp. 884-896, 2020.

Publisher : Biomater. Sci., The Royal Society of Chemistry

Year : 2019

Evaluation of Osseointegration of Staged or Simultaneously Placed Dental Implants with Nanocomposite Fibrous Scaffolds in Rabbit Mandibular Defect

Cite this Research Publication : Manju V., Dr. Subramania Iyer K., Dr. Deepthy Menon, Shantikumar V Nair, and Dr. Manitha B. Nair, “Evaluation of Osseointegration of Staged or Simultaneously Placed Dental Implants with Nanocomposite Fibrous Scaffolds in Rabbit Mandibular Defect”, Materials Science and Engineering C, vol. 104, 2019.

Publisher : Materials Science and Engineering

Year : 2018

Dual Release of growth Factor from Nanocomposite Fibrous Scaffold Promotes Vascularisation and Bone Regeneration in Rat Critical Sized Calvarial Defect.

Cite this Research Publication : S. Kuttappan, Mathew, D., Jo, J. - I., Tanaka, R., Menon, D., Ishimoto, T., Nakano, T., Shantikumar V Nair, Dr. Manitha B. Nair, and Tabata, Y., “Dual Release of growth Factor from Nanocomposite Fibrous Scaffold Promotes Vascularisation and Bone Regeneration in Rat Critical Sized Calvarial Defect.”, Acta Biomaterialia, vol. 78, pp. 36-47, 2018.

Publisher : Acta Biomaterialia,

Year : 2018

Poly(L-lactic acid) nanofibers containing Cissus quadrangularis induced osteogenic differentiation in vitro.

Cite this Research Publication : K. Parvathi, Krishnan, A. G., Anitha, A., Jayakumar, R., and Nair, M. B., “Poly(L-lactic acid) nanofibers containing Cissus quadrangularis induced osteogenic differentiation in vitro.”, Int J Biol Macromol, vol. 110, pp. 514-521, 2018.

Publisher : Int J Biol Macromol

Year : 2018

Poly(L-lactic acid) Nanofibers containing Cissus Guadrangularis induced Osteogenic Differentiation in Vitro

Cite this Research Publication : K. Parvathi, Krishnan, A. G., Anitha A., Dr. Jayakumar Rangasamy, and Dr. Manitha B. Nair, “Poly(L-lactic acid) Nanofibers containing Cissus Guadrangularis induced Osteogenic Differentiation in Vitro”, International Journal of Biological Macromolecules, vol. 110, pp. 514 - 521, 2018.

Publisher : International Journal of Biological Macromolecules

Year : 2018

Nanofibrous yarn reinforced HA-gelatin composite scaffolds promote bone formation in critical sized alveolar defects in rabbit model

Cite this Research Publication : Manju V., Anitha A., Dr. Deepthy Menon, Dr. Subramania Iyer K., Shantikumar V Nair, and Dr. Manitha B. Nair, “Nanofibrous yarn reinforced HA-gelatin composite scaffolds promote bone formation in critical sized alveolar defects in rabbit model”, Biomedical Materials, vol. 13, no. 6, p. 065011, 2018.

Publisher : Biomedical Materials

Year : 2018

BMP2 Expressing Genetically Engineered Mesenchymal Stem Cells on Composite Fibrous Scaffolds for Enhanced bone Regeneration in Segmental Defects

Cite this Research Publication : Shruthy Kuttappan, Anitha, A., Minsha Mallika Gopi, Menon, P. M., Sivanarayanan, T. B., Dr. Lakshmi Sumitra, and Dr. Manitha B. Nair, “BMP2 Expressing Genetically Engineered Mesenchymal Stem Cells on Composite Fibrous Scaffolds for Enhanced bone Regeneration in Segmental Defects”, Materials Science and Engineering: C, vol. 85, pp. 239 - 248, 2018.

Publisher : Materials Science and Engineering: C

Year : 2017

Electrospun Yarn Reinforced NanoHA Composite Matrix as a Potential Bone Substitute for Enhanced Regeneration of Segmental Defects.

Cite this Research Publication : A. Anitha, Joseph, J., Menon, D., Nair, S. V., and Nair, M. B., “Electrospun Yarn Reinforced NanoHA Composite Matrix as a Potential Bone Substitute for Enhanced Regeneration of Segmental Defects.”, Tissue Eng Part A, vol. 23, no. 7-8, pp. 345-358, 2017.

Publisher : Tissue Eng Part A

Year : 2017

Bioinspired Composite Matrix Containing Hydroxyapatite–Silica Core–Shell Nanorods for Bone Tissue Engineering

Cite this Research Publication : Anitha A, Menon, D., B, S. T., Koyakutty, M., Mohan, C. C., Nair, S. V., and Dr. Manitha B. Nair, “Bioinspired Composite Matrix Containing Hydroxyapatite–Silica Core–Shell Nanorods for Bone Tissue Engineering”, ACS Applied Materials & Interfaces, vol. 9, no. 32, pp. 26707–26718, 2017.

Publisher : ACS Applied Materials Interfaces

Year : 2017

Antibacterial and cytocompatible nanotextured Ti surface incorporating silver via single step hydrothermal processing

Cite this Research Publication : A. Mohandas, Krishnan, A. G., Dr. Raja Biswas, Dr. Deepthy Menon, and Dr. Manitha B. Nair, “Antibacterial and cytocompatible nanotextured Ti surface incorporating silver via single step hydrothermal processing”, Materials Science and Engineering C, vol. 75, pp. 115-124, 2017.

Publisher : Materials Science and Engineering C

Year : 2016

Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering – A mini review.

Cite this Research Publication : S. Kuttappan, Mathew, D., and Nair, M. B., “Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review.”, Int J Biol Macromol, vol. 93, no. Pt B, pp. 1390-1401, 2016.

Publisher : Int J Biol Macromol,

Year : 2016

Evaluation of osteoinductive and endothelial differentiation potential of Platelet-Rich Plasma incorporated Gelatin-Nanohydroxyapatite Fibrous Matrix

Cite this Research Publication : A. J, Shruthy Kuttappan, Keyan, K. S., and Dr. Manitha B. Nair, “Evaluation of osteoinductive and endothelial differentiation potential of Platelet-Rich Plasma incorporated Gelatin-Nanohydroxyapatite Fibrous Matrix”, Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 104, no. 4, pp. 771-781, 2016.

Publisher : Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year : 2016

Biomimetic Composite Scaffolds Containing Bioceramics and Collagen/Gelatin for Bone Tissue Engineering – A Mini Review

Cite this Research Publication : S. Kuttappan, Mathew, D., and Nair, M. B., “Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review.”, Int J Biol Macromol, vol. 93, no. Pt B, pp. 1390-1401, 2016.

Publisher : Int J Biol Macromol

Year : 2015

Evaluation of antibacterial activity and cytocompatibility of ciprofloxacin loaded gelatin-hydroxyapatite scaffolds as a local drug delivery system for osteomyelitis treatment

Cite this Research Publication : A. G. Krishnan, Jayaram, L., Dr. Raja Biswas, and Dr. Manitha B. Nair, “Evaluation of antibacterial activity and cytocompatibility of ciprofloxacin loaded gelatin-hydroxyapatite scaffolds as a local drug delivery system for osteomyelitis treatment”, Tissue Engineering - Part A, vol. 21, pp. 1422-1431, 2015.

Publisher : Tissue Engineering - Part A, Mary Ann Liebert Inc.,

Year : 2015

Relevance of fiber integrated gelatin-nanohydroxyapatite composite scaffold for bone tissue regeneration

Cite this Research Publication : Bibi Halima Shamaz, Anitha A., Manju V., Shruthy Kuttappan, Shantikumar V Nair, and Dr. Manitha B. Nair, “Relevance of fiber integrated gelatin-nanohydroxyapatite composite scaffold for bone tissue regeneration”, Nanotechnology, vol. 26, no. 40, p. 405101, 2015.

Publisher : Nanotechnology

Year : 2015

Applications of Titania Nanotubes in Bone Biology

Cite this Research Publication : Dr. Manitha B. Nair and Elizabeth, E., “Applications of Titania Nanotubes in Bone Biology”, Journal of Nanoscience and Nanotechnology, vol. 15, pp. 939–955, 2015.

Publisher : ournal of Nanoscience and Nanotechnology, American Scientific Publishers

Year : 2015

Composite hydrogel of chitosan-poly(hydroxybutyrate-co-valerate) with chondroitin sulfate nanoparticles for nucleus pulposus tissue engineering

Cite this Research Publication : Dr. Manitha B. Nair, Baranwal, G., Vijayan, P., Keyan, K. S., and Dr. Jayakumar Rangasamy, “Composite hydrogel of chitosan-poly(hydroxybutyrate-co-valerate) with chondroitin sulfate nanoparticles for nucleus pulposus tissue engineering”, Colloids and Surfaces B: Biointerfaces, vol. 136, pp. 84-92, 2015.

Publisher : Colloids and Surfaces B: Biointerfaces, Elsevier

Year : 2015

Characterization of an injectable, degradable polymer for mechanical stabilization of mandibular fractures

Cite this Research Publication : A. M. Henslee, Yoon, D. M., Lu, B. Y., Yu, J., Arango, A. A., Marruffo, L. P., Seng, L., Anver, T. D., Ather, H., Dr. Manitha B. Nair, and , “Characterization of an injectable, degradable polymer for mechanical stabilization of mandibular fractures”, Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 103, pp. 529–538, 2015.

Publisher : Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year : 2015

Graphene oxide nanoflakes incorporated gelatin–hydroxyapatite scaffolds enhance osteogenic differentiation of human mesenchymal stem cells

Cite this Research Publication : Dr. Manitha B. Nair, Nancy, D., Krishnan, A. G., Anjusree, G. S., Vadukumpully, S., and Shantikumar V Nair, “Graphene oxide nanoflakes incorporated gelatin–hydroxyapatite scaffolds enhance osteogenic differentiation of human mesenchymal stem cells”, Nanotechnology, vol. 26, p. 161001, 2015.

Publisher : Nanotechnology

Year : 2014

Antibiotic releasing biodegradable scaffolds for osteomyelitis

Cite this Research Publication : Dr. Manitha B. Nair and Krishnan, A., “Antibiotic releasing biodegradable scaffolds for osteomyelitis”, Current drug delivery, vol. 11, pp. 687–700, 2014.

Publisher : Current drug delivery

Year : 2014

ZnO nanoparticle incorporated nanostructured metallic titanium for increased mesenchymal stem cell response and antibacterial activity

Cite this Research Publication : E. Elizabeth, Baranwal, G., Krishnan, A. G., Menon, D., and Dr. Manitha B. Nair, “ZnO nanoparticle incorporated nanostructured metallic titanium for increased mesenchymal stem cell response and antibacterial activity”, Nanotechnology, vol. 25, 2014.

Publisher : Nanotechnology

Year : 2011

Tissue-engineered triphasic ceramic coated hydroxyapatite induced bone formation and vascularization at an extraskeletal site in a rat model

Cite this Research Publication : Dr. Manitha B. Nair, Varma, H. K., Mohanan, P. V., and John, A., “Tissue-engineered triphasic ceramic coated hydroxyapatite induced bone formation and vascularization at an extraskeletal site in a rat model”, Bulletin of Materials Science, vol. 34, pp. 1721–1731, 2011.

Publisher : Bulletin of Materials Science

Year : 2011

Infection and tissue engineering in segmental bone defects—a mini review

Cite this Research Publication : Dr. Manitha B. Nair, Kretlow, J. D., Mikos, A. G., and F Kasper, K., “Infection and tissue engineering in segmental bone defects—a mini review”, Current Opinion in Biotechnology, vol. 22, pp. 721 - 725, 2011.

Publisher : Current Opinion in Biotechnology

Year : 2011

Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in segmental long bone defects

Cite this Research Publication : A. M. Henslee, Spicer, P. P., Yoon, D. M., Dr. Manitha B. Nair, Meretoja, V. V., Witherel, K. E., Jansen, J. A., Mikos, A. G., and Kasper, F. K., “Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in segmental long bone defects”, Acta Biomaterialia, vol. 7, pp. 3627 - 3637, 2011.

Publisher : Acta Biomaterialia

Year : 2010

Adult Stem Cells on Methacrylic Acid Grafted Cocoon Silky Fibrous Scaffolds

Cite this Research Publication : Dr. Manitha B. Nair, S, M., S, N., K, S., M, J., and A, J., “Adult Stem Cells on Methacrylic Acid Grafted Cocoon Silky Fibrous Scaffolds”, Trends in Biomaterials and Artificial Organs , vol. 23, no. 3, pp. 137-144, 2010.

Publisher : Trends in Biomaterials and Artificial Organs

Year : 2010

Shaping the micromechanical behavior of multi-phase composites for bone tissue engineering

Cite this Research Publication : S. I. Ranganathan, Yoon, D. M., Henslee, A. M., Dr. Manitha B. Nair, Smid, C., F. Kasper, K., Tasciotti, E., Mikos, A. G., Decuzzi, P., and Ferrari, M., “Shaping the micromechanical behavior of multi-phase composites for bone tissue engineering”, Acta Biomaterialia, vol. 6, pp. 3448 - 3456, 2010.

Publisher : Acta Biomaterialia

Year : 2009

Treatment of Goat Femur Segmental Defects with Silica-Coated Hydroxyapatite—One-Year Follow-Up

Cite this Research Publication : Dr. Manitha B. Nair, Varma, H., Shenoy, S. J., and John, A., “Treatment of Goat Femur Segmental Defects with Silica-Coated Hydroxyapatite—One-Year Follow-Up”, Tissue Engineering Part A, vol. 16, no. 2, pp. 385-391, 2009.

Publisher : Tissue Engineering Part A

Year : 2009

Tissue regeneration and repair of goat segmental femur defect with bioactive triphasic ceramic-coated hydroxyapatite scaffold

Cite this Research Publication : Dr. Manitha B. Nair, Varma, H. K., Menon, K. V., Shenoy, S. J., and John, A., “Tissue regeneration and repair of goat segmental femur defect with bioactive triphasic ceramic-coated hydroxyapatite scaffold”, Journal of Biomedical Materials Research Part A, vol. 91A, no. 3, pp. 855–865, 2009.

Publisher : Journal of Biomedical Materials Research Part A

Year : 2009

A bioactive triphasic ceramic-coated hydroxyapatite promotes proliferation and osteogenic differentiation of human bone marrow stromal cells

Cite this Research Publication : Dr. Manitha B. Nair, Bernhardt, A., Lode, A., Heinemann, C., Thieme, S., Hanke, T., Varma, H., Gelinsky, M., and John, A., “A bioactive triphasic ceramic-coated hydroxyapatite promotes proliferation and osteogenic differentiation of human bone marrow stromal cells”, Journal of Biomedical Materials Research Part A, vol. 90, pp. 533–542, 2009.

Publisher : Journal of Biomedical Materials Research Part A

Year : 2009

Reconstruction of goat femur segmental defects using triphasic ceramic-coated hydroxyapatite in combination with autologous cells and platelet-rich plasma

Cite this Research Publication : Dr. Manitha B. Nair, Varma, H. K., John, A., Menon, V., and Shenoy, S., “Reconstruction of goat femur segmental defects using triphasic ceramic-coated hydroxyapatite in combination with autologous cells and platelet-rich plasma”, Acta Biomater , vol. 5, no. 5, 2009.

Publisher : Acta Biomater

Year : 2008

Evaluation of Biomaterials Using Micro‐Computerized Tomography

Cite this Research Publication : A. T. Arun Torris, Columbus, K. C. Soumya, Saaj, U. S., Dr. Manitha B. Nair, and Krishnan, K. V., “Evaluation of Biomaterials Using Micro‐Computerized Tomography”, AIP Conference Proceedings, vol. 1050, pp. 68-78, 2008.

Publisher : AIP Conference Proceedings

Year : 2008

Platelet-Rich Plasma and Fibrin Glue–Coated Bioactive Ceramics Enhance Growth and Differentiation of Goat Bone Marrow–Derived Stem Cells

Cite this Research Publication : Dr. Manitha B. Nair, Varma, H. K., and John, A., “Platelet-Rich Plasma and Fibrin Glue–Coated Bioactive Ceramics Enhance Growth and Differentiation of Goat Bone Marrow–Derived Stem Cells”, Tissue Engineering Part A, vol. 15, pp. 1619–1631, 2008.

Publisher : Tissue Engineering Part A

Year : 2008

Biodegradation and Cytocompatibility Studies of a Triphasic Ceramic-Coated Porous Hydroxyapatite for Bone Substitute Applications

Cite this Research Publication : A. John, Dr. Manitha B. Nair, Varma, H. K., Bernhardt, A., and Gelinsky, M., “Biodegradation and Cytocompatibility Studies of a Triphasic Ceramic-Coated Porous Hydroxyapatite for Bone Substitute Applications”, International Journal of Applied Ceramic Technology, vol. 5, pp. 11–19, 2008.

Publisher : International Journal of Applied Ceramic Technology

Year : 2008

Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair

Cite this Research Publication : Dr. Manitha B. Nair, Varma, H. K., and John, A., “Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair”, Journal of Materials Science: Materials in Medicine, vol. 20, p. 251, 2008.

Publisher : Journal of Materials Science: Materials in Medicine

Year : 2008

A triphasic ceramic-coated porous hydroxyapatite for tissue engineering application

Cite this Research Publication : Dr. Manitha B. Nair, S. Babu, S., Varma, H. K., and John, A., “A triphasic ceramic-coated porous hydroxyapatite for tissue engineering application”, Acta Biomaterialia, vol. 4, pp. 173 - 181, 2008.

Publisher : Acta Biomaterialia

Year : 2006

Cell Interaction Studies with Bioglass Coated Hydroxyapatite Porous Blocks

Cite this Research Publication : Dr. Manitha B. Nair, HK, V., TV, K., SS, B., and A, J., “Cell Interaction Studies with Bioglass Coated Hydroxyapatite Porous Blocks”, Trends in Biomaterials and Artificial Organs , vol. 19, no. 2, pp. 108-114, 2006.

Publisher : Trends in Biomaterials and Artificial Organs

Conference Paper

Year : 2016

Gelatinous matrix with Silica coated Nanohydroxyapatite as a Biomimetic scaffold for Bone Tissue Engineering

Cite this Research Publication : Dr. Manitha B. Nair, Shantikumar V. Nair, and A, A., “Gelatinous matrix with Silica coated Nanohydroxyapatite as a Biomimetic scaffold for Bone Tissue Engineering”, in NUS Joint International Conference on Biotechnology and Neuroscience - CUSBAN , 2016.

Publisher : NUS Joint International Conference on Biotechnology and Neuroscience - CUSBAN

Year : 2016

Relevance of Biopolymers & Nanocomposites in Tissue Engineering & Regenerative medicine

Cite this Research Publication : Dr. Manitha B. Nair, “Relevance of Biopolymers & Nanocomposites in Tissue Engineering & Regenerative medicine”, in National Technology Day – CBPST, 2016.

Publisher : National Technology Day – CBPST

Year : 2015

Relevance of Fiber Reinforced Gelatin-HA Composite Scaffold For Bone Tissue Regeneration

Cite this Research Publication : Dr. Manitha B. Nair, Nair, A. A., Menon, D., and Nair, S., “Relevance of Fiber Reinforced Gelatin-HA Composite Scaffold For Bone Tissue Regeneration”, in Indo-Australian Conference on Biomaterials & Tissue Engineering – BiTERM , 2015.

Publisher : Indo-Australian Conference on Biomaterials Tissue Engineering – BiTERM

Year : 2015

Evaluation of osteoinductive potential of Graphene oxide incorporated bioceramic composite scaffold for Bone tissue engineering

Cite this Research Publication : N. D, Vadukumpully, S., Nair, S., and Dr. Manitha B. Nair, “Evaluation of osteoinductive potential of Graphene oxide incorporated bioceramic composite scaffold for Bone tissue engineering”, in Indo-Australian Conference on Biomaterials & Tissue Engineering - BiTERM, 2015.

Publisher : Indo-Australian Conference on Biomaterials Tissue Engineering - BiTERM

Year : 2015

Development of composite scaffolds with genetically engineered stem cells expressing BMP2 for bone tissue engineering

Cite this Research Publication : Shruthy Kuttappan, V, L. Sumitra, and Dr. Manitha B. Nair, “Development of composite scaffolds with genetically engineered stem cells expressing BMP2 for bone tissue engineering”, in Indo-Australian Conference on Biomaterials & Tissue Engineering – BiTERM , 2015.

Publisher : Indo-Australian Conference on Biomaterials Tissue Engineering – BiTERM

Year : 2015

Ciprofloxacin loaded gelatin-hydroxyapatite scaffolds as a local drug delivery system for osteomyelitis treatment

Cite this Research Publication : Dr. Manitha B. Nair, Krishnan, A. G., Jayaram, L., and Raja Biswas, “Ciprofloxacin loaded gelatin-hydroxyapatite scaffolds as a local drug delivery system for osteomyelitis treatment”, in Indo-Australian Conference on Biomaterials & Tissue Engineering – BiTERM , 2015.

Publisher : Indo-Australian Conference on Biomaterials Tissue Engineering – BiTERM

Year : 2014

Gelatin-nanohydroxyapatite scaffold with micro/nano fibers – A novel biomimetic bone substitute for Orthopaedic applications

Cite this Research Publication : A. A. Nair, V, M., Shantikumar V. Nair, and Dr. Manitha B. Nair, “Gelatin-nanohydroxyapatite scaffold with micro/nano fibers - A novel biomimetic bone substitute for Orthopaedic applications”, in 7th Bangalore India Nano, 2014.

Publisher : 7th Bangalore India Nano

Year : 2014

Localized Drug Delivery in Bone tissue Engineering

Cite this Research Publication : Dr. Manitha B. Nair, “Localized Drug Delivery in Bone tissue Engineering”, in National Seminar on Recent Advances in Biotechnology, St. Joseph’s College, Irinjalakuda, Kerala, 2014.

Publisher : National Seminar on Recent Advances in Biotechnology

Year : 2014

Surgical alterations to enhance prosthetic outcome in maxillofacial rehabilitation

Cite this Research Publication : M. V, Dr. Manitha B. Nair, and Iyer, S., “Surgical alterations to enhance prosthetic outcome in maxillofacial rehabilitation”, in International Society for Maxillofacial Rehabilitation Conference China, 2014.

Publisher : International Society for Maxillofacial Rehabilitation Conference China

Year : 2013

Characterization of 3D bony scaffold of NanoHA-gelatin with PLLA electrospun sheet

Cite this Research Publication : Bibi Halima Shamaz, Nair, A. A., and Dr. Manitha B. Nair, “Characterization of 3D bony scaffold of NanoHA-gelatin with PLLA electrospun sheet”, in International Conference on Biotechnology for Innovative applications - Amrita Bioquest , 2013.

Publisher : International Conference on Biotechnology for Innovative applications - Amrita Bioquest

Year : 2013

Titania Nanotubes loaded with zinc oxide nanoparticles for improved osseointegration and antibacterial activity

Cite this Research Publication : E. Elizabeth, Nair, A. A., Menon, D., and Dr. Manitha B. Nair, “Titania Nanotubes loaded with zinc oxide nanoparticles for improved osseointegration and antibacterial activity”, in International Conference on Biotechnology for Innovative applications - Amrita Bioquest , 2013.

Publisher : International Conference on Biotechnology for Innovative applications - Amrita Bioquest

Year : 2013

Polymeric fiber containing nanohydroxyapatite based composite scaffolds for bone tissue engineering

Cite this Research Publication : A. A. Nair, Joseph, J., Koyakutty, M., Menon, D., Nair, S., and Dr. Manitha B. Nair, “Polymeric fiber containing nanohydroxyapatite based composite scaffolds for bone tissue engineering”, in International Conference on Biotechnology for Innovative applications - Amrita Bioquest , 2013.

Publisher : International Conference on Biotechnology for Innovative applications - Amrita Bioquest

Year : 2010

Serializing the data bus of the Sun OpenSPARC T1 microprocessor datapath for reduced power consumption

Cite this Research Publication : Rajesh Kannan Megalingam, Krishnan, V., Dr. Manitha B. Nair, Sarma, V., and Srikumar, R., “Serializing the Data Bus of the Sun OpenSPARC T1 Microprocessor Datapath for Reduced Power Consumption”, in ICWET 2010 - International Conference and Workshop on Emerging Trends in Technology 2010, Conference Proceedings, Mumbai, Maharashtra, 2010, pp. 868-873.

Publisher : ICWET 2010

Year : 2010

Information Processing via Post-synaptic EPSP-spike Complex and Model-based Predictions of Induced Changes during Plasticity in Cerebellar Granular Neuron

Cite this Research Publication : Dr. Manitha B. Nair, Melethadathil, N., Dr. Bipin G. Nair, Dr. Shyam Diwakar, and Manjusha Nair, “Information processing via post-synaptic EPSP-spike complex and model-based predictions of induced changes during plasticity in cerebellar granular neuron”, in Proceedings of the 1st Amrita ACM-W Celebration of Women in Computing in India, A2CWiC'10, Coimbatore, Sept 16-17, 2010.

Publisher : Proceedings of the 1st Amrita ACM-W Celebration of Women in Computing in India, A2CWiC'10, Coimbatore.

Book Chapter

Year : 2011

Bone Tissue Engineering Approaches and Challenges using Bioactive Ceramic Scaffolds

Cite this Research Publication : Dr. Manitha B. Nair, Sullivan, P. J., and Mortensen, E. K., “Bone Tissue Engineering Approaches and Challenges using Bioactive Ceramic Scaffolds”, Nova publishers, 2011, pp. 45-74.

Publisher : Nova publishers

Patents

Year : 2016

Porous Composite Fibrous Scaffold for Bone Tissue Regeneration

Cite this Research Publication : Dr. Manitha B. Nair, Dr. Deepthy Menon, and Shantikumar V. Nair, “Porous Composite Fibrous Scaffold for Bone Tissue Regeneration”, U.S. Patent 15/341,866 2016.

Publisher : Number 15/341,866.

Professional awards/Fellowships received
  • Kerala State Young Scientist Award 2016 for the outstanding contributions in Science and Technology (The award is given by Hon. Chief Minister of Kerala and the award includes 50,000 cash prize, gold medal, certificate, 50 lakhs research grant and an International travel support)
  • Best poster award for the student who presented research work at NUS Joint International Conference on Biotechnology and Neuroscience – CUSBAN 2016 (Authors: Anitha A, Shantikumar V. Nair, Manitha Nair*)
  • Best poster award for the student who presented research work at BiTERM 2016 Conference, IIT Delhi, April, 2016 (Authors: Anjana J, Manitha Nair*)
  • The paper published in Nanotechnology (Nair et al., 2015; 26:16100) is selected as one of the very best content published by IOP publishing in 2015-2016.
  • Selected for MAHE award (2015) for the best scientific paper presented by a Faculty during the Indo-Australian BiTERM Conference 2015
  • Selected for “Innovative Young Biotechnology Award 2012 awarded by Department of Biotechnology, Govt. of India” for nurturing innovative ideas in biotechnology (The award is given by Hon. Minister of Science and Technology, Govt. of India and the award includes 3 lakhs cash prize and 50 lakhs research grant)
  • The Young Scientists fellowship of the Department of Science and Technology 2012, Govt. of India (The award includes 25 lakhs research grant)
  • Best Poster presentation Award at NANOBIO 2009 The First International Conference on Tissue Engineering & Stem cells Research using Nanomaterials, organized by Amrita Centre for Nanosciences, Feb 17 – 19, 2009, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
  • Nair MB et al. A triphasic ceramic-coated porous hydroxyapatite for tissue engineering application. Acta Biomaterialia 2008; 4: 173–181 – Selected as “Featured article” by Elsevier publication in the year 2008.
  • Young Scientist Award in Health Science category in 19th Kerala Science Congress, held at Kannur, Kerala, India during Jan 29 – 31, 2007.
  • First Hitachi High Technologies Best Poster Award in Life Sciences in the National Conference on Electron Microscopy and XXVIII Annual meeting of Electron Microscope Society of India (EMSI) held at Regional Research Laboratory, Thiruvanathapuram, Kerala, India during April 19-21, 2006.
  • ZEISS Best Photomicrograph Award in life Sciences in National Conference on Electron Microscopy and XXVIII Annual meeting of Electron Microscope Society of India (EMSI) held at Regional Research Laboratory, Thiruvanathapuram, Kerala, India during April 19-21, 2006.
  • CSIR- UGC-NET Scholarship (2004)
  • Life member of Society for Tissue Engineering and Regenerative Medicine (India)
  • Life Member of Materials Research Society of India (MRSI)
Research Projects

 

Funding Agency Project Title Responsibility Status
Department of Science and Technology, Govt. of India (TPF Nano) Evaluation of fiber reinforced composite scaffolds in large animals for clinical translation Principle Investigator Ongoing
DST-JSPS Indo Japan Project Electrospun fiber reinforced gelatin-hydroxyapatite scaffolds for co-delivery of dual growth factors for bone regeneration Principle Investigator Completed
Department of Science and Technology, Govt. of India Antibiotic incorporated tissue-engineered multiscale fibrous scaffold for the treatment of osteomyelitis Principle Investigator Completed
Department of Biotechnology, Govt. of India Genetically Engineered BMP-2 and VEGF Expression in mesenchymal stem cells on 3D Scaffold for the treatment of segmental bone defect Principle Investigator Completed
Department of Science and Technology, Govt. of India (Thematic Unit of Excellence) Development and evaluation of biomimetic biomaterials for bone tissue regeneration Principle Investigator Completed

 

Research

Low Cost Biomimetic Grafts for Musculoskeletal Tissue Regeneration

Every year, millions of patients suffer loss or failure of an organ or tissue as a result of accident or disease. Tissue or organ transplantation is a commonly accepted norm under these circumstances, but its availability is very less. In our lab, we focus on the fabrication of extracellular matrix mimicking nanocomposite scaffolds that provide structural support and proliferating cues for stem cells to form new tissue. The scaffolds are tuned to induce lineage specific differentiation of mesenchymal stem cells. Specifically, we focus on the development of biomaterials for bone and cartilage tissue, its GMP scaling up and clinical translation.

Functional and Vascularized Biomaterials for Critical-sized Defects

One of the greatest challenges in tissue engineering is to develop functional and vascularized large-scale tissue substitutes. In our lab, we functionalize biomaterials for use as delivery systems for growth factors, small molecules and phytochemicals. The incorporation of these biosignalling cues has shown to enhance the functionality of endothelial cells, leading to better blood vessel formation and tissue regeneration in critical sized defects in animal models within shorter period.

Biodegradable Antibiotic-Impregnated Scaffold for Osteomyelitis Treatment

Osteomyelitis is a severe, progressive inflammatory process caused by Staphylococcus aureus bacteria. Management of infected bone with local antibiotic delivery system (PMMA) achieves therapeutic drug concentration at the site, however PMMA beads are non-biodegradable. Our lab focus on the development of biodegradable antibiotic loaded scaffold for reducing bacterial contamination in chronic osteomyelitis, so as to avoid revision surgery.

Osseointegration Studies of Metallic Implants with Bone Tissue

Osseointegration describes direct anchorage and integration of a Ti or stainless steel implant (orthopaedic or dental) with living bone. The success of this adaptation depends on several factors, including the organization and density of the bone surrounding the implant, the implant design, and surgical technique used. Our group evaluates the impact of quality of bone in determining the primary and secondary stability of dental implants.

Intervertebral Disc Regeneration

Degeneration of the intervertebral disc causes low back pain in around 80% of adults. Current treatments include spinal fusion and artificial disc replacement, but these may alter the biomechanics of adjacent discs and cause subsequent degeneration. In our lab, research is ongoing to develop mechanically stable and biofunctional injectible composite hydrogels for intervertebral disc regeneration.

Admissions Apply Now