Qualification: 
Ph.D
Email: 
sudarslal@am.amrita.edu
Phone: 
+91 (0476-2803119)

Dr. Sudarslal S. currently serves as Associate Professor at the School of Biotechnology. He was conferred with a Ph. D. in Biophysics, School of Biosciences, M. G. University, Kerala. Prior to joining Amrita, he served as a scientist at the Mass Spectrometry Core Facility, NCBS, Bangalore.

Current Research

We mainly focus on applying analytical techniques to isolate, purify and characterize a wide range of bioactive molecules from plant extracts, marine endophytes and snake venoms.  We are also actively involved in the development mass spectrometry work-flows to quantitate metabolites from biological matrices.

Professional Affiliations:

  • Life Member, Indian Society for Mass Spectrometry
  • Life Member, Proteomics Society of India

Teaching

Odd Semester

Even Semester

PUBLICATIONS

Journal Articles:

Year of Publication Title
2020 Drishya, G., Nambiar, J., Shaji, S.K., Vanuopadath, M., Achuthan, A., Kumar, A., Alias, A., Sherif, A., Joseph, C., Divya, P., Kumar, D.S., Bose, C., Nair, S.V., Nair, S.S., Kumar, G.B., Lakshmi, S., Nair, B.G., RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata, Journal of Biosciences, 45 (1), Article number: 89.DOI: 10.1007/s12038-020-00056-z.[Abstract]
2020 S., Athavale, D., Ramteke, P., Vanuopadath, M., Nair, B.G., Nair, S.S., Bhat, M.K., Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by Chouhan, S., Singh glucose-dependent alterations in reactive oxygen species, P-glycoprotein and DKK4, Journal of Biosciences, 45 (1), Article number: 97. DOI: 10.1007/s12038-020-00065-y.[Abstract]
2020 Vanuopadath, M., Shaji, S.K., Raveendran, D., Nair, B.G., Nair, S.S., Delineating the venom toxin arsenal of Malabar pit viper (Trimeresurusmalabaricus) from the Western Ghats of India and evaluating its immunological cross-reactivity and in vitro cytotoxicity, International Journal of Biolgoical Macromolecules, 148, pp. 1029-1045. DOI: 10.1016/j.ijbiomac.2020.01.226. [Abstract]
2020 Vanuopadath, M., Raveendran, D., Nair, B.G., Nair, S.S., Evaluating the Immunological cross-reactivity of Indian polyvalent antivenoms towards the venom of Hypnalehypnale (hump-nosed pit viper) from the Western Ghats, bioRxiv.DOI: 10.1101/2020.08.01.232579. [Abstract]
2019 Pushkaran, A.C., Vinod, V., Vanuopadath, M., Nair, S.S., Nair, S.V., Vasudevan, A.K., Biswas, R., Mohan, C.G., Combination of Repurposed Drug Diosmin with Amoxicillin-Clavulanic acid Causes Synergistic Inhibition of Mycobacterial Growth, Scientific Reports, 9 (1), Article number: 6800. DOI: 10.1038/s41598-019-43201-x. [Abstract]
2019 Nair, D., Vanuopadath, M., Balasubramanian, A., Iyer, A., Ganesh, S., Anil, A.N., Vikraman, V., Pillai, P., Bose, C., Nair, B.G., Pai, J.G., Nair, S.S., Phlorotannins from Padina tetrastromatica: structural characterisation and functional studies, Journal of Applied Phycology, 31 (5), pp. 3131-3141. DOI: 10.1007/s10811-019-01792-y. [Abstract]
2019 Nedungadi, D., Binoy, A., Vinod, V., Vanuopadath, M., Nair, S.S., Nair, B.G., Mishra, N., Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage, Nutrition and Cancer, DOI: 10.1080/01635581.2019.1685113. [Abstract]
2019 Vanuopadath, M., Sajeev, N., Murali, A.R., Sudish, N., Kangosseri, N., Sebastian, I.R., Jain, N.D., Pal, A., Raveendran, D., Nair, B.G., Nair, S.S., Mass spectrometry-assisted venom profiling of Hypnalehypnale found in the Western Ghats of India incorporating de novo sequencing approaches, International Journal of Biological Macromolecules, 118, pp. 1736-1746. DOI: 10.1016/j.ijbiomac.2018.07.016. [Abstract]
2019 Nair, D., Krishna, J.G., Panikkar, M.V.N., Nair, B.G., Pai, J.G., Nair, S.S., Identification, purification, biochemical and mass spectrometric characterization of novel phycobiliproteins from a marine red alga, Centrocerasclavulatum, International Journal of Biological Macromolecules, 114, pp. 679-691. DOI: 10.1016/j.ijbiomac.2018.03.153. [Abstract]
2018 Chatterjee, M., D’Morris, S., Paul, V., Warrier, S., Vasudevan, A.K., Vanuopadath, M., Nair, S.S., Paul-Prasanth, B., Mohan, C.G., Biswas, R., Mechanistic understanding of Phenyllactic acid mediated inhibition of quorum sensing and biofilm development in Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 101 (22), pp. 8223-8236. DOI: 10.1007/s00253-017-8546-4. [Abstract]
2018 Jayalekshmi H., Omanakuttan, A., Menon, N. D., Muralidharan Vanuopadath, Nair, S. Sadasivan, Corriden, R., Nair, B. G., Nizet, V., and Kumar, G. B., “Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa.”, Sci Rep, vol. 8, no. 1, p. 3437, 2018. DOI: 10.1038/s41598-018-19771-7 [Abstract]
2016 Vanuopadath, M., Nair, D., Nair, B.G., Nair, S.S., Post-translational modifications of proteins: Biomarkers and therapeutic targets for diabetes related complications, Current Proteomics, 13 (4), pp. 251-270. DOI: 10.2174/1570164613666161031155258. [Abstract]/
2016 Malvi, P., Chaube, B., Singh, S.V., Mohammad, N., Pandey, V., Vijayakumar, M.V., Radhakrishnan, R.M., Vanuopadath, M., Nair, S.S., Nair, B.G., Bhat, M.K., Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance, Cancer & Metabolism, 4:21. DOI: 10.1186/s40170-016-0162-8. [Abstract]
2016 Divya Nair, Muralidharan Vanuopadath, Bipin G. Nair, Jayashree Gopalakrishna Pai, Sudarslal Sadasivan Nair, “Identification and characterization of a library of surfactins and fengycins from a marine endophytic Bacillus sp.”, Journal of Basic Microbiology, 2016 [Abstract]
2015 N. Mohammad, Singh, S. Vikram, Malvi, P., Chaube, B., Athavale, D., Vanuopadath, M., Sudarslal, S., Bipin G. Nair Dr., and Bhat, M. Kumar, “Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complex”, Scientific reports (Article number 11853), vol. 5, 2015 [Abstract]
2013 K. Ajesh, Sudarslal, S., Arunan, C., and Sreejith, K., “Kannurin, a Novel Lipopeptide from Bacillus Cereus Strain AK1: Isolation, Structural Evaluation and Antifungal Activities”, Journal of Applied Microbiology, vol. 115, pp. 1287–1296, 2013 [Abstract]
2011 R. Banerjee, Sudarslal, S., Ranganayaki, R. S., and Raghothama, S., “Effect of Ester Chemical Structure and Peptide Bond Conformation in Fragmentation Pathways of Differently Metal Cationized Cyclodepsipeptides”, Org. Biomol. Chem., vol. 9, pp. 6234-6245, 2011.[Abstract]
2006 S. Sudarslal, Nilsson, C. L., Emmett, M. R., Schaub, T. M., Gowd, K. Hanumae, Thakur, S. S., Krishnan, K. S., Balaram, P., and Marshall, A. G., “De Novo Sequencing and Disulfide Mapping of a Bromotryptophan-Containing Conotoxin by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry”, Analytical Chemistry, vol. 78, pp. 8082-8088, 2006 [Abstract]
2006 S. Sudarslal, Romanuka, J., Billeter, M., Skjeldal, L., Emmett, M. R., Nilsson, C. L., and Marshall, A. G., “Structural Characterization of an Unusually Stable Cyclic Peptide, Kalata \{B2\} from Oldenlandia Affinis”, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol. 1764, pp. 1568 - 1576, 2006 [Abstract]
2006 V. Sabareesh, K. Gowd, H., Ramasamy, P., Sudarslal, S., Krishnan, K. S., Sikdar, S. K., and Balaram, P., “Characterization of Contryphans from Conus Loroisii and Conus Amadis that Target Calcium Channels”, Peptides, vol. 27, pp. 2647 - 2654, 2006.[Abstract]
2005 Gowd, K Hanumae; Sabareesh V; S. Sudarslal; Iengar, Prathima; Franklin, Benjamin; Fernando, Antony; Dewan, Kalyan; Ramaswami, Mani; Sarma, Siddhartha P.;Sikdar, Sujit; Balaram, P; Krishnan, K S, “Novel Peptides of Therapeutic Promise from Indian Conidae”, Annals of the New York Academy of Sciences, vol. 1056, pp. 462–473, 2005 [Abstract]
2005 R. Sampathkumar, Balasubramanyam, M., Sudarslal, S., Rema, M., Mohan, V., and Balaram, P., “Increased Glutathionylated Hemoglobin (HbSSG) in Type 2 Diabetes Subjects with Microangiopathy”, Clinical Biochemistry, vol. 38, pp. 892 - 899, 2005. [Abstract]
2005 S. P. Sarma, G. Kumar, S., Sudarslal, S., Iengar, Prathima, Ramasamy, P., Sikdar, S. K., Krishnan, K. S., and Balaram, P., “Solution Structure of δ-Am2766: A Highly Hydrophobic δ-Conotoxin from Conus amadis That Inhibits Inactivation of Neuronal Voltage-Gated Sodium Channels”, Chemistry & Biodiversity, vol. 2, pp. 535–556, 2005 [Abstract]
2004 S. Sudarslal, Singaravadivelan, G., Ramasamy, P., Ananda, K., Sarma, S. P., Sikdar, S. K., Krishnan, K. S., and Balaram, P., “A Novel 13 Residue Acyclic Peptide from the Marine Snail, Conus Monile, Targets Potassium Channels”, Biochemical and Biophysical Research Communications, vol. 317, pp. 682 - 688, 2004 [Abstract]
2004 A. Mathew, Kurup, G. M., Gopalakrishnapai, J., Sudarslal, S., and Vasundhara, G., “Antitumour Property of Vinblastine Monohydrazide”, Indian Journal of Pharmaceutical Sciences, vol. 66, pp. 117–120, 2004.[Abstract]
2003 J. Gopalakrishnapai, Kurup, G. M., Sudarslal, S., and Jacob, V. B., “Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice”, Fitoterapia, vol. 74, pp. 431 - 434, 2003. [Abstract]
2003 S. Sudarslal, Majumdar, S., Ramasamy, P., Dhawan, R., Pal, P. P., Ramaswami, M., Lala, A. K., Sikdar, S. K., Sarma, S. P., Krishnan, K. S., and Balaram, P., “Sodium Channel Modulating Activity in a δ-Conotoxin from an Indian Marine Snail”, \{FEBS\} Letters, vol. 553, pp. 209 - 212, 2003 [Abstract]

Book Chapters:

Year of Publication Title
2015 S. Sudarslal,  Balaram P; Laladhas K. P., “Identification, Purification and Mass Spectrometric Characterization of Two Novel Cyclic Peptides from Clitoria ternatea”, in Biodiversity Conservation - Challenges for the Future, vol. 209-216, Bentham E-Books, 2015 [Abstract]
2013 N. Ajayakumar, Schrenk, W., Bipin G. Nair Dr., and Sudarslal, S., “Mass Spectrometric Characterization of a Novel Antimicrobial Peptide Isolated from Clitoria Ternatea”, in Prospects in Bioscience: Addressing the Issues, A. Sabu and Augustine, A. Springer India, 2013, pp. 251-256.[Abstract]

Conference Proceedings:

Year of Publication Title
2018 Vanuopadath,M., Raveendran,D., Nair, B.G., Nair,S.S., Proteomic investigation of complex venom toxin arsenal of Hypnalehypnale from the Western Ghats of India, 10th annual meeting of proteomics society of India-International conference on proteomics for cell biology and molecular medicine, NCCS, Pune, India, December 12-14.[Abstract]
2017 Vanuopadath, M., Alangode, A., Rajan, K., Sajeev, N., Raveendran, D., Reick, M., Reick, M., Nair, B.G., Nair,S.S., Proteomic investigation of Trimeresurusmalabaricus venom and its comparative functional analysis using Daboia Russelii venom, SnakeSymp- Snake venom research and snakebite therapy, Centre for Cellular and Molecular Biology, Hyderabad, India, December 1-3. [Abstract]
2017 Vanuopadath, M., Nair, B.G., Nair, S.S., Mass spectrometry based quantitation of oxidized and reduced glutathione under diabetes-induced oxidative stress conditions, 27th Swadeshi Science Congress , Swadeshi Science Movement-Kerala, India, November 7-9. [Abstract]
2014 Divya Nair, Muralidharan V., Bipin Nair , Jayashree G. and Sudarslal S., Isolation and Characterisation of Lipopeptides from a Bacillus subtilis sp. Strain, a marime algal endophyte, in proceedings of the fourth International Seminar on "Sustainable Utilisation of Tropical Plant Biomass- Ayur informatics, pp. 89-91, 2014.[Abstract]
2013 Mass spectrometric characterization of lipopeptides from Bacillus cereus-AK1 at the Amrita BioQuest 2013 an International conference on Biotechnology for innovative applications, Kollam, from August 10-14, 2013.
2013 Isolation and characterization of host-binding proteins from Bacillus calausii using mass spectrometry at the Amrita BioQuest 2013 an International conference on Biotechnology for innovative applications, Kollam, from August 10-14, 2013.
2012 Identification, purification and characterization of two novel cyclic peptides from Clitoria ternatea at the National Biodiversity Conference-2012, Thiruvananthapuram, from December 27-30, 2012.
2012 Mass spectrometric characterization of a novel antimicrobial peptide isolated from Clitoria ternatea at the International Conference on Advances in Biological Sciences, Kannur, from March 15-17, 2012.
2007 Two-dimensional gel separation followed by ESI FT-ICR MS for differential membrane proteome analysis of Borrelia burgdorferi, a causative agent of lyme disease, at the 55th ASMS conference, Indianapolis, from June 3-7, 2007.
2007 A middle-down approach to determine disulfide connectivity of GM2 activator protein by FT-ICR mass spectrometry, at the 6th North American FT-ICR MS conference, Tahoe city, California, from April 1-5, 2007.
2006 FT-ICR MS-based structural characterization of a novel conotoxin from Conus monile: Determination of bromotryptophan by use of electron capture dissociation, at the 54th ASMS conference, Seattle, Washington, from May 28 to June 1, 2006.
2005 Activated Ion-Electron Capture Dissociation of Kalata B2, a cyclic peptide containing three disulfide bonds, at the 53rd ASMS conference on Mass Spectrometry, San Antonio, Texas, from June 5-9, 2005.
2004 Sequencing of Conus peptides by mass spectral methods, at the Keystone Symposia,  Santa Fe, USA, from 14- 19th February 2004.
2004 Electrospray ionization mass spectrometry in the analysis of β- thalassemia and hemoglobin abnormalities, at the 11th ISMAS-WS 2004 workshop on Mass Spectrometry, Shilon Bagh, Shimla, from October 7-12, 2004.
2004 Isolation and characterization of biologically active peptides from Indian marine snails, at the National seminar on new frontiers in marine bioscience research, Chennai, from January 22-23, 2004.
1997 Anti-tumor property of L-asparaginase, at the Ninth Kerala Science Congress, Trivandrum, from January 27- 29, 1997.

Invited Talks – Conferences/ Workshops/Course Works:

Year of Publication Title
2019 Chromatography- Fundamentals and Applications, National Workshop on Research Methodology, SreeNeelakanta Govt. Sanskrit College, Pattambi, January 31.
2018 Impact of guggulsterone on diabetes-related complications: An investigative analysis using quantitative mass spectrometry, RCB-Mass Spectrometry and Proteomics Workshop, Regional Centre for Biotechnology, Faridabad, December 18.
2018 Mass Spectrometers- New Generation Sniffer Dogs for Biomolecular Discovery, National Seminar 2018, Proteins and Prospects, Government Arts and Science College, Kozhinjampara, November 22.
2017 Exploring the Venom of Malabar Pit Viper: Proteomics and Functional Studies, 27th Swadeshi Science Congress , Swadeshi Science Movement-Kerala, November 9.
2017 ExBiological Mass Spectrometry: A Bird's-eye view, NMR and MS-Theory, Instrumentation and Application in Chemical /Biological Research, Srinivasa Ramanujan Institute for Basic Sciences (SRIBS), Kottayam, October 2017.
2017 Mass spectrometers- Next generation sniffer dogs and beyond, National symposium on the Innovative Trends in Chemical Education and Research: Hurdles and Successive Progress, Sree Narayana College, Kollam, March 22
2015 Disulfide bond mapping by mass spectrometry" in the National Colloquium on Nuclear Magnetic Resonance (NMR) Spectroscopy & Mass Spectrometry (MS): Biological Appliations, on July 31, 2015, Organized by Srinivasa Ramanujan Institute for Basic Sciences, Kottayam
2015 Peptidomics: a logical outcome of proteomics" in the National Seminar on New Perspectives in Proteomics, on March 27, 2015, Organized by IU-CGGT, Dept. of Biotechnology, University of Kerala, Thiruvananthapuram
2015 “Primer to HPLC” in the Workshop on HPLC, on March 11, 2015, Organized by Pushpagiri Institute of Medical Science and Research Centre, Thiruvalla.
2014 “Application of Mass Spectrometry in the Study of Proteins” in the UGC sponsored seminar on Interdisciplinary Research in Chemical Sciences, on December 31, 2014, Organized by N.S.S. College, Kottiyam, Thiruvananthapuram.
2014 “Ion Trap Mass Spectrometry” in the KSCSTE sponsored National Seminar on Recent Approaches in Biochemical Research (RABR-2014) on October 29, 2014, Organized by Department of Biochemistry, University of Kerala, Thiruvananthapuram.
2014 "Applications of proteomics in biological research”, in the course work for Ph.D. candidates conducted by School of Biosciences, Mahatma Gandhi University, Kottayam, on July 17, 2014.
2014 “Role of mass spectrometry for petidome research”, in the one day workshop conducted by the Department of Computational Biology and Bioinformatics, Kerala University, Thiruvananthapuram, on June 15, 2014.
2013 “Electrospray Ionization Ion Trap Mass Spectrometry for Cyclic Peptide Characterization” in the Amrita BioQuest 2013 on August 14, 2013, conducted by Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam.
2013 “Applications of spectroscopy in biological research” in the course work for Ph.D. candidates conducted by School of Biosciences, Mahatma Gandhi University, Kottayam, on August 1, 2013.
2013 “Biological mass spectrometry: Fundamentals and applications” in the workshop on NMR and MS organized by Kerala State Council for Science, Technology and Environment and Sophisticated Test and Instrumentation Centre, Cochin University of Science and Technology, Cochin, on July 20, 2013.
2011 “Role of mass spectrometry based proteomics in immunology research” in the National Seminar on Current Concepts in Immunology conducted by St. Thomas College, Kozhencherry on August 19, 2011.
2011 “Proteomics for biological discovery” in the course work for Ph.D. candidates conducted by School of Biosciences, Mahatma Gandhi University, Kottayam, on May 18, 2011.
2011 “Fundamentals of mass spectrometry and proteomics” in the National level refresher course for college and University teachers conducted by Kannur University, on March 05, 2011.
2010 “Mass spectrometers: Magnificent arsenals of analytical world” at the Department of Biotechnology, Manipal University, on August 24, 2010.
2005 “Tandem mass spectrometry in the analysis of abnormal hemoglobins” at the Mar Athanasius College for Advanced Studies, Thiruvalla, on January 25, 2005.
2004 "Characterization of Abnormal Hemoglobins”, at the 11th ISMAS-WS 2004 workshop on Mass Spectrometry held at Shilon Bagh, Shimla, from October 7-12, 2004, organized by Indian Society for Mass Spectrometry.
2004 “Isolation and characterization of biologically active peptides from Indian marine snails”, at the National seminar on new frontiers in marine bioscience research, held at Chennai, organized by National Institute of Ocean Technology, conducted from 22- 23rd January 2004.

Invited Roles

  • Adjunct faculty, Institute for Integrated programmes and Research in Basic Sciences (IIRBS), Kottayam, Kerala, 2020.
  • Member, Inter University Instrumentation Centre, Mahatma Gandhi University, Kottayam, Kerala, 2017.
  • PhD. Thesis Evaluator: Bharathiyar University, Coimbatore, Tamilnadu.
  • PhD. Thesis Evaluator: Mahatma Gandhi University, Kottayam, Kerala.
  • External Member, PhD. Committee, Centre for Bio-Separation Technology (CBST), Vellore Institute of Technology, Tamilnadu.
  • External Examiner for MPhil. And MSc. Programs, Mahatma Gandhi University, Kottayam, Kerala.
  • External Examiner for MSc. Program, Kannur University, Kannur, Kerala.
  • Journal Reviewer: Expert Review of Proteomics, Taylor & Francis.
  • Journal Reviewer: Journal of Venomous Animals and Toxins including Tropical Diseases, Springer Nature.
  • Journal Reviewer: Journal of Applied Phycology, Springer.
  • Journal Reviewer: Biological Research, Springer Nature.
  • Journal Reviewer: Annals of the Brazilian Academy of Sciences, SciELO.
  • Reviewer and Local Organizer: 27th Swadeshi Science Congress, Kollam, Kerala,
  • Program Committee Member, NAAC-sponsored National Seminar on “Curriculum Design for Sustainable and Societal Development: A Road Map”, Amrita Vishwa Vidyapeetham, Coimbatore, Tamilnadu, August 12-13, 2016.
  • Reviewer and Local Organizer: International Conference on Biotechnology for Innovative Application (Amrita Bioquest 2013), Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, Kerala, August 10-13, 2013.
  • Session Chair, 11th ISMAS-WS 2004 workshop on Mass Spectrometry, Shilon Bagh, Shimla, October 7-12, 2004.