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Course Detail

Course Name Regenerative Medicine & Tissue Engineering
Course Code 25NBT512
Program M. Sc. Nanobiotechnology (NBT)
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

Biologic and Molecular Basis for Regenerative Medicine:Current perspectives in Regenerative Medicine; Types of Tissues; Molecular organisation of cells; Extracellular Matrix; Cell-extracellular matrix interactions

Unit 2

Cellular aspect of Regenerative Medicine: Stem cells and progenitors; Types of stem cells, Embryonic stem cells, induced pluripotent stem cells, Mesenchymal stem cells, Hematopoietic stem cells, Adult stem cells

Unit 3

Different Stages of Tissue Regeneration: Basic cell structure and functions; Tissue organisation and functions; Organ structure and functions, Scar and Regeneration; Different stages of regeneration – Hemostasis, Inflammation, Proliferation, Angiogenesis, Remodelling; Case studies – Skin regeneration, Bone regeneration, Liver regeneration.

Unit 4

Tissue Engineering: Relevance of tissue engineering; Triad of Tissue engineering – Scaffolds Types (Ceramics, Polymers, Composites Biomimetic scaffold); Cells, Growth factors; Case Studies: Ectoderm derived tissues (Nerve tissue, Cornea), Endoderm derived tissues (Liver, Pancreas), Mesoderm (Bone, Cartilage, Muscle, blood vessels, ligament, Tendon). Recent advances in biofabrication; 3D bioprinting

Objectives and Outcomes

Pre-requisites: Undergraduate level basic physics, chemistry and biology

Total number of classes: 45

COURSE OUTCOMES:

Upon successful completion, students will have the

  • Understanding on the molecules and signalling pathways that regulate epithelial and mesenchymal states of tissues and cell – extracellular matrix interactions
  • Knowledge on the various types and sources of stem cells and their role in tissue growth, repair and regeneration
  • Understanding on the importance of vascularisation and the challenges associated with establishing vascularisation in tissue engineered constructs
  • Knowledge on the inherent regenerative mechanisms in human body
  • Knowledge on the therapeutic applications of cells, and cells derived products in regenerative medicine

COURSE OUTCOMES:

CO1: Understand the molecular and biological foundations of regenerative medicine, including tissue types, cell organization, extracellular matrix, and cell-matrix interactions.

CO2: Demonstrate knowledge of various stem cell types and their roles in tissue regeneration, including embryonic, induced pluripotent, and adult stem cells.

CO3: Describe the stages of tissue regeneration and the biological processes involved, including inflammation, angiogenesis, and remodeling, with reference to specific case studies.

CO4: Explain the principles and components of tissue engineering, including scaffold types, cellular elements, and growth factors, and their role in regenerating tissues from different germ layers.

CO5: Evaluate recent advancements in tissue engineering technologies, including biofabrication and 3D bioprinting, and their applications in clinical regenerative medicine.

PROGRAM OUTCOME:

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity

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PROGRAM SPECIFIC OUTCOMES (PSO):

PSO1: Mastery of Nanomaterial Science and Characterization

PSO2: Understanding of Cellular and Molecular Systems

PSO3: Application of Nanobiotech in Diagnostics and Therapy

PSO4: Experimental Design and Data Analysis

PSO5: Research Competency and Methodological Rigor

PSO6: Industry and Career Readiness

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Text Books / References

TEXT BOOK

Principles of Regenerative Medicine, Anthony Atala, Robert Lanza James, Thomson Robert Nerem, 2nd Edition, Elsevier -2010

REFERENCES:

1. Ying Deng and Jordan Kuiper, Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications (Woodhead Publishing Series in Biomaterials), 2017

  1. Cato T. Laurencin, Lakshmi S. Nair. Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition, CRC Press 2017

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