Unit 1
Nanomedicine: Basic concepts in the design of nanomedicine, Basics of cancer biology, treatment options, desired specifications and features of cancer-nanomedicine, Concept of SMART nanomedicine
| Course Name | Cancer Nanotechnology |
| Course Code | 25NBT542 |
| Program | M. Sc. Nanobiotechnology (NBT) |
| Credits | 3 |
| Campus | Kochi |
Nanomedicine: Basic concepts in the design of nanomedicine, Basics of cancer biology, treatment options, desired specifications and features of cancer-nanomedicine, Concept of SMART nanomedicine
Nanomedicines for chemotherapy, cytotoxic drugs for cancer therapy, their merits and de-merits, how nanomedicines improve efficacy and safety of cytotoxic drugs, case studies: Abraxane, Doxil, Daunosome,
Important considerations of nanomaterials used for cancer-nanomedicine: Nanomedicines using polymers, lipids, liposomes, proteins, inorganic material systems, nano-injectables, oral delivery systems, nano-implants, case study: nano-implant/gel for brain tumor
Nanomedicine using Molecularly targeted drugs, methods of targeting multiple cancer mechanisms using single nanomedicines, Case study: Core-shell systems for leukemia and liver cancer
Nanomedicine for radiation therapy: Basics of radiation therapy, mechanisms, image guided radiation therapy, IGMRT, methods of improving radiation therapy using nanoparticles
Nano-photodynamic therapy, nano-photothermal therapy and nano-RF hyperthermia therapy, nano-scintillation therapy,
Nanoparticles based cancer immunotherapy, basic immunology, nanoparticle-vaccines, mRNA and Peptide vaccines, emerging trends in nano-immunotherapy of cancer , CAR-T cell therapy, toxicity concerns in immunotherapy
Nano-bio-therapeutics in cancer, nanoparticle mediated cell therapy, CART cell DC vaccines, use of nanoparticles in gene-therapy: DNA, RNA delivery.
Safety aspects of nanomedicine: How to study safety of nanomedicines, in vitro, in vivo, toxicity assays, regulatory guidelines
Pre-requisites: Undergraduate level Physics, Chemistry, & Biology
Total number of classes: 45
Course objectives
COURSE OUTCOME:
CO1: To understand distinguishing features of normal medicine versus nanomedicine
CO2: To understand design aspects of nanomedicine, considering cancer as a model disease
CO3: To understand various types of nanomedicines depending on the cancer types and their methods of preparation
CO4: To understand methods of studying the safety aspects of nanomedicines
CO5: Decipher information about how nanomedicine formulations are regulated by Govt agencies for its safe application in human after preclinical and clinical trials
CO6: Case studies on currently used nanomedicines for various cancer types
PROGRAM OUTCOME:
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
MAPPING (CO/PO)
0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity
|
CO |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
CO1 |
3 |
2 |
3 |
2 |
3 |
3 |
2 |
2 |
1 |
2 |
2 |
3 |
|
CO2 |
3 |
3 |
3 |
2 |
3 |
3 |
2 |
3 |
2 |
2 |
2 |
3 |
|
CO3 |
3 |
2 |
3 |
2 |
3 |
3 |
2 |
2 |
2 |
2 |
2 |
3 |
|
CO4 |
3 |
2 |
3 |
3 |
3 |
3 |
3 |
3 |
2 |
2 |
3 |
3 |
|
CO5 |
3 |
2 |
2 |
3 |
2 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
|
CO6 |
3 |
3 |
3 |
3 |
3 |
3 |
2 |
2 |
2 |
3 |
3 |
3 |
PROGRAM SPECIFIC OUTCOMES (PSO):
PSO1: Mastery of Nanomaterial Science and Characterization
PSO2: Understanding of Cellular and Molecular Systems
PSO3: Application of Nanobiotech in Diagnostics and Therapy
PSO4: Experimental Design and Data Analysis
PSO5: Research Competency and Methodological Rigor
PSO6: Industry and Career Readiness
MAPPING (CO/PSO)
|
CO |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
|
CO1 |
3 |
2 |
3 |
3 |
3 |
3 |
|
CO2 |
3 |
3 |
3 |
3 |
3 |
3 |
|
CO3 |
3 |
3 |
3 |
3 |
3 |
3 |
|
CO4 |
3 |
3 |
3 |
3 |
3 |
3 |
|
CO5 |
2 |
2 |
3 |
3 |
3 |
3 |
|
CO6 |
3 |
3 |
3 |
3 |
3 |
3 |
TEXT BOOK
Understanding Nanomedicine: An Introductory Textbook Rob Burgess, CRC Press, 2012.
REFERENCE:
DISCLAIMER: The appearance of external links on this web site does not constitute endorsement by the School of Biotechnology/Amrita Vishwa Vidyapeetham or the information, products or services contained therein. For other than authorized activities, the Amrita Vishwa Vidyapeetham does not exercise any editorial control over the information you may find at these locations. These links are provided consistent with the stated purpose of this web site.