| Course Name | Molecular Basis of Diseases |
| Course Code | 25CLG515 |
| Program | M. Sc. Clinical Genomics |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
(Lectures 10)
Introduction to Genomics: Genome structure and function (DNA, RNA, genes, and regulatory elements), Human genome and variation (e.g., SNPs, CNVs). Epigenomics (DNA methylation, histone modifications, and their role in gene regulation). Transcriptomics (Gene expression and RNA sequencing).
(Lectures 8)
Molecular basis of Cell cycle, differentiation and death.
(Lectures 4)
Monogenic and polygenic disorders
(Lectures 8)
Cancer genomics (driver mutations, oncogenes, tumor suppressor genes), Consequence of these mutations in the protein level.
(Lectures 5)
Microbial genomics and its role in infectious diseases.
(Lectures 5)
Role of genomics in complex diseases (e.g., diabetes, cardiovascular diseases, neurodegenerative diseases, autoimmune diseases, pulmonary and thrombotic diseases).
(Lectures 5)
From Molecular Mechanisms to Therapeutic Opportunities for cancer and neurodegenerative diseases. Utility of identified molecules as biomarkers related to disease. Translational importance of the identified biomarkers in the diagnosis, prognosis and identification of drug targets leading to development of diagnostics and therapeutics.
Pre-requisites: Understanding the genetic and microbial diseases at molecular level.
Total number of classes: 45
Course Outcome
CO1 Students will develop a comprehensive understanding of how molecular changes in the DNA influencing protein function.
CO2 Students will develop an understanding about basis of cell function and how many diseases are coupled with cell cycle differentiation and death.
CO3 Students will gain an understanding about disorders arising due to polygenic and monogenic changes.
CO4: Students will demonstrate an understanding about cancer genomics and the consequence of mutations in gene and its effect in various disorders.
CO5: Students will develop an understanding on how molecular mechanisms and pathways are harnessed to develop therapies.
Programme Outcomes (PO)
(As given by NBA and ABET)
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
CO–PO Mapping Table:
|
COs |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
CO1 |
3 |
2 |
2 |
2 |
2 |
– |
– |
2 |
– |
– |
– |
3 |
|
CO2 |
3 |
3 |
2 |
2 |
– |
– |
– |
– |
– |
– |
– |
2 |
|
CO3 |
3 |
3 |
2 |
3 |
2 |
– |
– |
– |
– |
– |
– |
3 |
|
CO4 |
3 |
3 |
2 |
3 |
3 |
2 |
– |
3 |
– |
– |
– |
3 |
|
CO5 |
3 |
3 |
3 |
3 |
3 |
3 |
– |
3 |
– |
2 |
2 |
3 |
Program Specific Outcomes (PSO):
PSO1. Apply fundamental molecular biology principles to interpret clinical genomic data.
PSO2. Use molecular techniques (e.g., PCR, RT-PCR, sequencing) to detect genetic mutations and biomarkers.
PSO3. Analyze genotype-phenotype correlations in inherited and acquired disorders.
PSO4. Identify pathogenic variants from NGS data and interpret their clinical relevance.
PSO5. Correlate molecular pathways with disease mechanisms and therapeutic targets.
PSO6. Develop and validate diagnostic assays based on molecular biology principles.
PSO7. Utilize molecular biology to support pharmacogenomics profiling and therapy optimization.
PSO8. Integrate multi-omic data (genomic, transcriptomic, epigenetic) for personalized health solutions.
PSO9. Apply molecular knowledge to cancer genomics, infectious diseases, and rare genetic disorders.
PSO10. Translate molecular discoveries into clinical interventions through evidence-based practice.
CO–PSO Mapping Table:
|
COs |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
PSO8 |
PSO9 |
PSO10 |
|
CO1 |
3 |
– |
2 |
– |
2 |
– |
– |
– |
– |
– |
|
CO2 |
3 |
– |
2 |
– |
2 |
– |
– |
– |
– |
– |
|
CO3 |
3 |
– |
3 |
– |
2 |
– |
– |
– |
– |
2 |
|
CO4 |
3 |
– |
3 |
2 |
2 |
– |
– |
– |
3 |
3 |
|
CO5 |
3 |
– |
3 |
2 |
3 |
3 |
3 |
2 |
2 |
3 |
Evaluation Pattern: 50+50 = 100
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/Test/Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% | |
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