Publication Type : Journal Article
Publisher : Elsevier BV
Source : Microbial Pathogenesis
Url : https://doi.org/10.1016/j.micpath.2025.107856
Keywords : K. pneumoniae, Intracellular survival, macrophage polarization, autophagy, apoptosis, pyroptosis, inflammasome, immunomodulation, host directed therapy
Campus : Amritapuri
School : School of Biotechnology
Year : 2025
Abstract : K. pneumoniae has emerged as a major infectious threat due to its remarkable capacity for intracellular survival, virulence, and antibiotic resistance. It evades immune clearance by resisting phagocytosis through capsular polysaccharides and lipopolysaccharides, modulating macrophage polarization to create a permissive intracellular niche, and autophagic degradation. Additionally, it alters cytokine responses and interferes with host cell death pathways like apoptosis and pyroptosis to suppress inflammasome activation and efferocytosis. These immune evasion strategies are particularly concerning in the context of emerging MDR and hypervirulent strains. In response, host directed therapies (HDTs), including epigenetic and immunomodulatory interventions, offer promising non-antibiotic based strategies. Understanding the host pathogen interaction is essential to guide future therapeutic development.
Cite this Research Publication : Abhinand Kuniyil, Arjun M. Menon, Shwetha Susan Thomas, Avandika B. Anil, Parvathi Mohanan PC, Arun KB, Lekshmi K. Edison, Pradeesh Babu, Geetha B. Kumar, Bipin G. Nair, Aravind Madhavan, Klebsiella pneumoniae: Host Interactions, Virulence Mechanisms, and Novel Therapeutic Strategies, Microbial Pathogenesis, Elsevier BV, 2025, https://doi.org/10.1016/j.micpath.2025.107856