Unit 1
History & Basic concepts of development: Overview of how the modern era of developmental biology emerged through multidisciplinary approaches, stages of development- zygote, blastula, gastrula, neurula.
| Course Name | Developmental Biology |
| Course Code | 25BIO312 |
| Program | B.Sc. (Honours) in Microbiology and lntegrated Systems Biology |
| Semester | 6 |
| Credits | 3 |
| Campus | Amritapuri |
History & Basic concepts of development: Overview of how the modern era of developmental biology emerged through multidisciplinary approaches, stages of development- zygote, blastula, gastrula, neurula.
Cell fate & commitment: potency- concept of embryonic stem cells, differential gene expression, terminal differentiation, lineages of three germ layers, fate map.
Mechanisms of differentiation: cytoplasmic determinants, embryonic induction, concept of morphogen, mosaic and regulative development.
Specification of adult stem cells. Pattern formation: axis specification, positional identification (regional specification). Morphogenetic movements, Model organisms in Developmental biology: Early Development in invertebrate /vertebrate models Drosophila, C.elegans,Xenopus, Mouse/ human: Cleavage, gastrulation, Axis specification (Dorsoventral, anterior posterior), & body plan patterning, left right asymmetry in vertebrates
Late Development in invertebrate /vertebrate models: Organogenesis- development of central nervous system in vertebrates, vulval formation in C. elegans, Germ cell specification& migration, Importance of developmental genes. Medical implications of developmental biology – genetic errors/ teratogenesis/ stem cell therapy etc.
LEARNING OBJECTIVES:
To provide an understanding about the basic principles of development of multicellular organisms. To provide an understanding of the role of genes in development. To compare the development of different organisms and to understand the similarities in development. To highlight the application of the field in stem cell therapy, regenerative medicine, drug development etc.
COURSE OUTCOMES:
After completing the course, students shall be able to
CO1. Students recognize the various processes that happen during the development of different organisms.
CO2. Students relate the role of genes during development.
CO3. Students predict the problems that can happen by mutation in genes during development.
CO4. Students compare the development of different organisms.
CO5. Students summarise the major genes and signalling processes during the development.
CO6. Students infer basis of different congenital disorders in humans.
REFERENCES:
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