Course

Unit 1

Introduction to Pharmacology – Fundamental Principles of Pharmacology, Fundamentals of Cardiovascular, Endocrine, and Immunopharmacology.

Unit 2

Introduction to Drug Discovery – Contemporary Approaches to Drug Discovery, Development and Delivery, Fundamentals of Drug Evaluation and Pharmacogenomics, FDA rules and regulations for the approval of new drugs, Major companies in the pharmaceutical industry, Biopharmaceuticals, Nutraceuticals, Economics of drug development.

Unit 3

Pharmacodynamics and Pharmacokinetics- Receptor theory & kinetics, Dose-response relationships, Mechanism of drug action, Phase I and phase II of drug metabolism, Drug efficacy, Pharmacokinetics concepts, Pharmacogenomics, Principles of Toxicology.

Unit 4

Principles of Chemotherapy- Principles of antimicrobial and antineoplastic chemotherapy, Types of selective targeting by drugs, Antibacterial and antifungal drugs and mechanisms of action, Antiparasitic drugs and mechanisms of action, Antiviral drugs and mechanisms of action, Antineoplastic drugs and mechanisms of action, Combination chemotherapy (with respect to antimicrobial and antineoplastic drugs).

Unit 5

Intellectual Property Rights with respect to Pharmaceuticals.

LEARNING OBJECTIVE:

To provide an understanding about the basic concept of drug discovery & designing, mechanism of action of different drugs, pharmacodynamics, pharmacokinetics, pharmacogenomics etc.

COURSE OUTCOMES:

After completing the course, students shall be able to

CO1.  The students shall be able to understand the basics of pharmacology, various stages of drug discovery and intellectual property rights.

CO2. To help the students to understand the basic concepts and principles behind pharmacokinetics, pharmacodynamics and toxicology.

CO3.  To make the students familiarize with the principles of antimicrobial and anti-neoplastic chemotherapy.

REFERENCES:

1. Pharmaceutical Biotechnology Fundamentals and Applications by Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm , Springer New York.
2. Principles of Pharmacology by D. Golan, A. Tashjian, E. Armstrong, J.Galanter, A.W. Armstrong, Arnaout and H.Rose.   , Lippincott Williams and Wilkins.