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Course Detail

Course Name Biology of Tissue & Organ Development
Course Code 25SCR514
Program M. Sc. Stem Cell Technology and Regenerative Medicine
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

7 Hrs

Foundational Concepts: Introduction to Developmental Biology: What is developmental biology, its history, and key questions: Questions of differentiation, morphogenesis, growth, reproduction and regeneration; Model Organisms used for studying development; Methods of Studying Development: Fate mapping, lineage tracing, and genetic approaches.

Unit 2

10 Hrs

Early Development: Fertilization and Early Cleavage: The process of fertilization and the initial cell divisions of the zygote; Gastrulation: Formation of germ layers (ectoderm, mesoderm, endoderm); Axis Formation: How the body axes (anterior/posterior, dorsal/ventral, left/right) are established; Pattern Formation: How cells acquire their identities and spatial organization.

Unit 3

10 Hrs

Cellular and Molecular Mechanisms underlying Development: Cell-Cell Communication: How cells communicate with each other during development; Signaling Pathways: Understanding key signaling pathways like Wnt, Notch, and Hedgehog; Differential Gene Expression: How genes are turned on and off during development; Morphogenesis: The processes that generate the shape and form of tissues and organs; Cell Differentiation: How cells become specialized.

Unit 4

10 Hrs

Organ and Tissue Development: Organogenesis: The development of specific organs and tissues; Development of the nervous system, limbs, heart, and other organs; Regeneration: The ability of some organisms to regenerate lost tissues or body parts.

Unit 5

8 Hrs

Later Development and Developmental disorders: Aging and Senescence: The processes of aging and the decline of tissues and organs; Developmental Disorders: How developmental processes can go wrong, leading to birth defects and diseases.

Introduction

Preamble

This course will describe the cellular and molecular mechanisms involved in the development of organisms including mammals. Specifically, the course will deal with pattern formation, developmental organization, axis formation, 3 germ layer formation, organogenesis and implications of development in health and disease. The course is expected to provide the students a deeper understanding about the developmental origin of health and disease in adulthood.

Objectives and Outcomes

Course Outcomes

CO1 To understand the key questions in developmental biology and foundational concepts used for studying development

CO2 To learn about early development and mechanisms involved in axis formation

CO3 To learn about early events at the cellular and molecular levels leading to genesis of tissues and organs

CO4 To learn about morphogenesis of specific organs

CO5 To have a perspective about processes involved in decline of organ functions due to aging and developmental disorders

Program outcome

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Life long learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

C

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

3

1

2

2

2

3

2

–

–

–

–

3

CO 2

3

1

2

2

2

3

2

–

–

–

–

3

CO 3

3

1

2

2

2

3

2

–

–

–

–

3

CO 4

3

1

2

2

2

3

2

–

–

–

–

3

CO 5

3

1

2

2

2

3

3

–

–

–

–

3

Program Specific Outcomes. (PSO)

PSO1. Demonstrate comprehensive knowledge of stem cell biology and their clinical and research relevance.

PSO2. Apply core laboratory techniques for stem cell isolation, characterization, and manipulation.

PSO3. Integrate principles of tissue engineering and biomaterials for regenerative applications.

PSO4. Analyze drug delivery, pharmacokinetics, and bioinformatics relevant to stem cell-based therapies.

PSO5. Evaluate ethical, regulatory, and translational aspects of stem cell product development.

PSO6. Bridge basic science with translational approaches in regenerative medicine and gene therapy.

PSO7. Design and interpret experimental strategies for stem cell-based disease

modeling and preclinical studies.

–

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

PSO7

C O

CO 1

3

–

–

–

–

2

–

CO 2

–

–

–

–

–

2

–

CO 3

2

2

–

CO 4

2

–

–

–

–

2

–

CO 5

2

–

–

–

–

2

–

Evaluation Pattern

Evaluation Pattern: 50+50 = 100

Internal Assessment – 50%
Periodical 1  Exam 20%
Periodical 2  Exam 20%
Continuous Assessment  Assignment/Test/Quiz 10%
50%
End Semester Examination- 50%
Theory Exam 50%
50%
Total 100%

 

Textbooks/ References

Textbooks:

  • Gilbert: Developmental Biology (11th ed., 2006, Sinauer)
  • Balinsky: An Introduction to Embryology (1981, CBS)
  • kakaWolpert: Principles of Development (3rd ed. 2007, Oxford)

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