Course

Unit 1Sources of natural products: Primary and Secondary Metabolites, Traditional Sources of Natural Products, Sources of Microbes, Venoms and Toxins, A brief account of major classes of secondary metabolites with special reference to plant families such as Zingiberacea, vitaceae, asteraceae, celastraceae, sapindaceae, moraceae, musaceae, fabaceae,etc : Alkaloids triterpenoids, flavanoids, phenolics and phenolic acids, Steroids, Coumarines, Quinines, Cyanogenic glycosides, Amines and non protein aminoacids, Nutraceuticals and PharmaceuticalsUnit 2Extraction of Natural Products: Water-Steam Distillation, Supercritical Fluid Extraction, Solvent Partitioning , Refined Isolation Techniques and Chromatography, Separations of Nonpolar and polar Compounds, Charcoal, Reverse Phase Resins, High-PerformanceUnit 3Separation, Purification and characterisation techniques- TLC, HPLC, HPTLC Liquid Chromatography, Capillary Electrophoresis, Polyamide Gel Chromatography, Size-Exclusion Chromatography and GC. Characterization techniques- LC-MS, ID and 2D NMR experiments, Cell culture techniques,NMR, UV-IR, XRay Crystallography,Circular dichroism ,Mass spectrometryUnit 4Anti-Infectives from Nature-Antimicrobial ?-Lactams, Structure Elucidation of Penicillin, Isolation of Penicillin, Cephalosporin, Isolation of Cephalosporin C, Isolation of Thienamycin, Antibiotic Macrolides: Erythromycin, Antiparasitic Drugs: Avermectins, Tetracyclines, Terpenes in Human Health.Unit 5Natural Products in Food, Spices, and Toxins Sweeteners, Xylitol,Aspartame, Sucralose, Stevia, Licorice, Agave ,Spices, Examples of Toxins from Plants,Toxic Mushroom: Amanita sp, Marine Toxins from Algae, Marine Toxins: Fish, Spider Venom,Conus Snail Toxins, Poisonous Frogs

Text Books1. Natural Products Chemistry- Sources, Separations, and Structures- Raymond Cooper, George Nicola 2015 by Taylor & Francis Group, LLC, CRC Press2. Plant-derived Natural Products- Synthesis, Function, and Application- Anne E. Osbourn Virginia Lanzotti, Springer3.Bioactive natural products: detection, isolation ansd structural determination Ed By Sm Colegate & RJ Molyneux, CRC Press, (2007)REFERENCES1.Natural products: Essential resources for human survival, Y. Z. Zhu et al, World Scientific Publishingn Co. Pte Ltd, London(2007)2.Medicinal natural Products: A biosynthetic approach, Paul M. Dewick, John Wiley &Sons(2001)3.Bioactive natural products: detection, isolation ansd structural determination Ed By Sm Colegate & RJ Molyneux, CRC Press, (2007)4. Natural Products Isolation, S D Sarker et al, Humana Press, (2005)5.Bioactive Compounds from Natural Sources, Second Edition, Corrado Tringali, CRC Press,20116. Chemistry for Pharmacy Students, General, Organic and Natural Product Chemistry,Satyajit D. Sarker University of Ulster, Coleraine, Northern Ireland, UK Lutfun Nahar,University of Ulster, Coleraine, orthern Ireland, UK, John Wiley and Sons,LTD., 20067.Chemistry of Natural Products, Sujata V. Bhat, Bhimsen A. Nagasampagi, MeenakshiSivakumar,First Edition , Springer, Berlin , 20058-Trease, G.E.and Evans, W.C.; Pharmacognosy, W.B. Saunders Publishers, Ltd, 15th ed., 2002.