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Course Detail

Course Name Drug Delivery, Pharmacokinetics & Pharmacodynamics
Course Code 25SCR513
Program M. Sc. Stem Cell Technology and Regenerative Medicine
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

(8 lecture)

Fundamental concepts of drug delivery: Physicochemical Properties of Drugs, Effects of fundamental physicochemical properties on the biopharmaceutical behavior of drugs, Concentration-time curve of pharmacokinetics; Fundamentals of controlled drug delivery, Pharmacokinetic and pharmacodynamic basis of controlled drug delivery, Physicochemical and biological factors influencing design and performance of controlled release products.

Unit 2

(15 lecture)

Routes of Drug Delivery: Enteral – Oral, Sublingual, Buccal, Rectal; Parenteral – Intravenous, Intramuscular, Intra-arterial, Intra-thecal, Intradermal; Topical – Transdermal, Intranasal, Conjuctival; Conventional drug delivery systems; Concept of active and passive targeting of drugs

Unit 3

(15 lecture)

Introduction to pharmacokinetics; Route of administration of drugs; Pharmacokinetic Parameters – bioavailability, biological Half-life, volume of distribution and clearance; Absorption of drugs; Mechanism of drug absorption; Factors affecting drug absorption; Distribution of drugs; Protein binding of drugs; Factors affecting distribution of drugs; Metabolism of drugs; Excretion of drugs; Kinetic models

Unit 4

(7 lecture)

Introduction to pharmacodynamics, drug-receptor interaction, body compartment systems, Drug Action – Action and effect, Excitation and Inhibition, Selectivity of drug action, Therapeutic effect and adverse reaction, Principles of Drug action- Dose effect relationship, Time effect relationship, structure activity relationship,Mechanism of drug action- Simple physical and chemical property, involving or interfering physiological and biochemical process of living system.

Introduction

Pre-requisites: Basic level biology and biochemistry

Total number of classes: 45

Objectives and Outcomes

Course Outcome

CO1 Be able to articulate the drug-intrinsic and extrinsic factors that determine drug molecule movement across biological membranes

CO2 To demonstrate understanding in concepts that determine dosage, absorption, distribution, and excretions of drugs, along with model systems connected with these concepts and apply pharmacokinetic principles to explain variation in drug disposition

CO3 To understand the basic concepts of drug delivery and physiochemical properties of the drug

CO4 To demonstrate understanding of different routes of drug administration and different drug delivery systems.

CO5 To understand basics of pharmacodynamics.

Program Outcome 

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

2

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

3

2

2

2

2

2

–

–

–

1

–

2

CO 2

3

3

2

3

2

2

–

–

–

1

–

3

CO 3

3

2

3

2

2

2

–

–

–

1

–

2

CO 4

3

2

3

2

2

2

1

–

–

1

–

2

CO 5

3

2

2

2

1

2

–

–

–

1

–

2

Program Specific Outcomes. (PSO)

PSO1. Demonstrate comprehensive knowledge of stem cell biology and their clinical and research relevance.

PSO2. Apply core laboratory techniques for stem cell isolation, characterization, and manipulation.

PSO3. Integrate principles of tissue engineering and biomaterials for regenerative applications.

PSO4. Analyze drug delivery, pharmacokinetics, and bioinformatics relevant to stem cell-based therapies.

PSO5. Evaluate ethical, regulatory, and translational aspects of stem cell product development.

PSO6. Bridge basic science with translational approaches in regenerative medicine and gene therapy.

PSO7. Design and interpret experimental strategies for stem cell-based disease

modeling and preclinical studies.

C

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

PSO7

C O

CO 1

–

–

–

–

–

–

–

CO 2

–

–

–

3

–

–

–

CO 3

–

–

–

–

–

3

–

CO 4

–

–

–

3

–

2

–

CO 5

–

–

–

3

–

2

–

Evaluation Pattern

Evaluation Pattern: 50+50 = 100

Internal Assessment – 50%
Periodical 1 Exam 20%
Periodical 2 Exam 20%
Continuous Assessment Assignment/Test/Quiz 10%
50%
End Semester Examination- 50%
Theory Exam 50%
50%
Total 100%

Textbooks/ References

  1. Robert E. Notari; Biopharmaceutics and Clinical Pharmacokinetics: An Introduction, Fourth Edition, 2017
  2. Leon Shargel, Susanna Wu-Pong, Andrew Yu; Applied Biopharmaceutics & Pharmacokinetics 5th edition, McGraw-Hill Medical 2004
  3. Rowland and Tozer, Clinical Pharmacokinetics: Concepts and Applications, 1995.
  4. Drug Delivery: Fundamentals and Applications, Second Edition, CRC Press 2017.
  5. Drug Delivery Systems, Pieter Stroeve and Morteza Mahmoudi, World Scientific Series: From Biomaterials towards Medical Devices, Vol I, 2018.
  6. Rosenbaum SE, editor. Basic pharmacokinetics and pharmacodynamics: An integrated textbook and computer simulations. John Wiley & Sons; 2016

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