Course

Unit III

Heterocyclic CompoundsNomenclature and general characteristics of heterocyclic compounds, study of three- and four-membered ring heterocycles containing one heteroatom, structure and synthesis of penicillin and cephalosporin-C, structure and synthesis of reserpine, heteroaromatic compounds (five- and six-membered rings) containing one and two heteroatoms, fused ring compounds – indole, quinoline, isoquinoline, coumarin, flavones, purine and pyrimidine, bases present in nucleosides.

Unit IV

Carbohydrates and Nucleic AcidsNomenclature aldoses, ketoses, furanoses, pyranoses. Classification monosaccharides, disaccharides and polysaccharides. Structure (Fischer, Haworth and chair projection) of ribose, glucose, fructose, maltose, sucrose, lactose, starch, cellulose and cyclodextrins. Preparation of alditols, glycosides, deoxysugars.Biosynthesis of vitamin C from glucose. Structure and synthesis of nucleic acids, genetic code, recombinant DNA. Biosynthesis of shikimic acid

Unit V

Chemistry of Natural ProductsAlkaloids – classification, structure elucidation based on degradative reactions (quinine atropine), terpenoids – classification, structure elucidation and synthesis of abietic acid, terpenoids. Total synthesis of quinine and papaverine (morphine, heroin).

SteroidsSteroids – classification, structure of cholesterol, conversion of cholesterol to progesterone, androsterone and testosterone, classification, structure and synthesis of prostaglandins, biosynthesis of fatty acids, prostaglandins, and steroids.

Amino acids, Peptides and EnzymesSynthesis of amino acids – Strecker and azlactone synthesis, reactions of amino acids, structure of proteins, introduction to enzymes and coenzymes with special reference to the function of chymotrypsin, NAD, thiamine, pyridoxal, solid phase synthesis choice of resin, classification and reactions leading to peptide formation.

TEXT BOOKS1.I.L. Finar Organic Chemistry vol 2 ( 3rd.ed.) Longmans Green & Co. 19642.Sujata V. Bhat, Bhimsen A. Nagasampagi, Meenakshi Sivakumar, Chemistry of Natural Products, Springer 2005REFERENCES1.K. C. Nicolaou, Eric J. Sorensen, Classics in Total synthesis, Wiley, 1996.2.Ashutosh kar, Chemistry of Natural Products, (Volume I and II), CBS