| Course Name | Nano biomaterials & Tissue Interaction |
| Course Code | 25NBT503 |
| Program | M. Sc. Nanobiotechnology (NBT) |
| Semester | 1 |
| Credits | 3 |
| Campus | Kochi |
Introduction to Biomaterials: Basic concepts of biomaterials science, definition, Concept of biocompatibility.
Classes of biomaterials in Medicine: Metals, Ceramics, Polymers, Composites; Bioresorbable; Bioinert, Bioactive and Biomimetic Materials, Materials at the Nanoscale – nanoparticles, nanofibers, nanocomposites
Biomaterials Fabrication: Solvent casting, salt leaching and lyophilisation, Electrospinning, Hydrogels, Cryogels, Surface modified biomaterials, 3D printing, 3D bioprinting-Cell encapsulation, Current advances and challenges in 3D printing.
Material-tissue interactions: Protein and Cell-Material interactions, Blood – material interactions, Inflammatory and immune response to biomaterials, Angiogenic response to biomaterials
Influence of Nanoscale Properties on Cellular Interactions – Porosity, Mechanical strength, Surface characteristics & modifications, Degradation
COURSE OUTCOMES:
CO1 – Understand the basic concept of a biomaterial and its applications in medicine
CO2 – Comprehend the different types of biomaterials and nanobiomaterials used in diverse biomedical applications, with their specific properties
CO3 – Learn about the diverse biofabrication techniques for developing biomaterial scaffolds
CO4 – Decipher the interactions of biomaterials with proteins and cells and how nanoscale size effects influence the biological interactions
CO5 – Understand the biological response subsequent to the implantation of biomaterials in a human body.
PROGRAM OUTCOME:
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity
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PROGRAM SPECIFIC OUTCOMES (PSO):
PSO1: Mastery of Nanomaterial Science and Characterization
PSO2: Understanding of Cellular and Molecular Systems
PSO3: Application of Nanobiotech in Diagnostics and Therapy
PSO4: Experimental Design and Data Analysis
PSO5: Research Competency and Methodological Rigor
PSO6: Industry and Career Readiness
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TEXTBOOKS/REFERENCES:
1.Biomaterials Science: An Introduction to Materials in Medicine, Edited by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen,Jack E. Lemons. 2020
3.Cato T. Laurencin, Lakshmi S. Nair. Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition, CRC Press 2017
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