Course

Unit 1

Medicinal chemistry: Introduction, drugs classification of drugs mechanism of drug action. Drug-receptor complex, nomenclature agonist,

Unit 2

Physicochemical Properties of Drugs in Relation to Biological Action: solubility, partition coefficient, dissociation constant, hydrogen bonding, ionization, drug shape, surface activity, complexation, protein binding, molar refractivity, bioisosterism stereo chemical aspects of drug action.Enzymes, hormones and vitamins – representative cases, nomenclature, classification and characteristics of enzymes, mechanism of enzyme action, factors affecting enzyme action, co-factors and co-enzymes, enzymes in organic synthesis, mechanism of enzyme catalysis, enzyme inhibition. Hormones and vitaminsrepresentative cases.

Unit 3

Essentials of Drug DesignMolecular mimetics, drug-lead modification, drug design using QSAR and computer assisted design, assessment of drug activity, receptors and drug action, mechanism of drug action, drug metabolism pathways, drug potentiation, drug antagonism and drug resistance

Unit 4

Medicinal Agents from Natural ProductsHistory of the use of natural products as therapeutic agents, medicinal plants, active principle, isolation methods of alkaloids, terpenes, antioxidants, natural oils from plants

Unit 5

Medicinal AgentsMedicinal agents belonging to alkaloids, steroids, polypeptides, modified nucleic acid bases, sulphonamide and sulpha drugs, antibacterials – sulpha drugs, substituted sulphonamides, anticonvulsants, anticoagulants, antiamoebic agents, anthelmintic agents, anti-malarial agents, diuretics and cardio vascular agents, medicinal agents affecting CNS, analgesics, antipyretics, antiseptics and disinfectants, histamine and anti- histaminic agents. Infectious and non-infectious diseases (malaria, AIDS, Cancer) introduction, mechanism of action types of cure.

TEXTBOOKS

1.John M beak and John H Block, T Wilson, O. Gisvold and R. F. Deorge – Text book of Organic, Medicinal and Pharmaceutical Chemistry, 7th edition, J.B. Lippincott Williams and Wilkons Company, 1977.

2.A. Burger, Medicinal Chemistry, 3rd edition, Wiley Interscience, 1970.

3.V.K. Ahluwalia and Madhu Chopra, Medicinal Chemistry, Ane Books Pvt. Ltd, 2008.

REFERENCES

1.V. Kothekar, Essentials of Drug Designing, 14th edition, Dhruv publications, 2005.

2.V.K. Ahluwalia, Lalita S. Kumar and Sanjiv Kumar, Chemistry of Natural Products, Ane Books India.

3.L.P. Graham An introduction to Medicinal Chemistry, 3rd edition, Oxford University Press, 2005