| Course Name | Molecular Biology |
| Course Code | 24MMD502 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 1 |
| Credits | 3 |
| Campus | Faridabad, Kochi |
DNA: Structure and function, Chromosome and chromatin, Genetic code, wobble hypothesis, RNA and types of RNA (rasiRNA, tasiRNA, nat-siRNA, piRNA), Proteins and their structure
DNA replication and its regulation, Homologous and site-specific recombination, DNA repair
Transcription and its regulation, Translation and its regulation, Gene structure, Repeats and clusters, Gene expression regulations: operon, Epigenetics
Types of mutations, Genetic system of mitochondria
Gene identification, promoter identification, Molecular biology techniques: Isolation and Quantification of DNA/RNA, PCR, Reverse transcriptase PCR, Real Time PCR, DNA Sequence analysis, hybridization (southern, northern and western) and Sanger sequencing.
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
|
C |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
C O |
||||||||||||
|
CO 1 |
3 |
1 |
– |
– |
– |
– |
– |
– |
– |
– |
– |
2 |
|
CO 2 |
3 |
1 |
– |
– |
1 |
– |
– |
– |
– |
– |
– |
1 |
|
CO 3 |
3 |
2 |
1 |
2 |
2 |
1 |
– |
– |
– |
– |
– |
1 |
|
CO 4 |
3 |
3 |
1 |
2 |
2 |
– |
– |
– |
– |
– |
– |
2 |
|
CO 5 |
3 |
1 |
2 |
1 |
3 |
2 |
– |
– |
– |
– |
– |
1 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular basis of disease
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cellular based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
|
– |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
PSO8 |
PSO9 |
PSO10 |
|
C O |
||||||||||
|
CO 1 |
3 |
2 |
1 |
– |
1 |
– |
– |
– |
– |
1 |
|
CO 2 |
3 |
2 |
1 |
– |
1 |
_ |
– |
– |
– |
1 |
|
CO 3 |
3 |
2 |
3 |
– |
1 |
1 |
– |
– |
– |
– |
|
CO 4 |
3 |
3 |
3 |
1 |
1 |
– |
– |
– |
– |
2 |
|
CO 5 |
– |
2 |
– |
3 |
2 |
2 |
– |
– |
– |
3 |
Evaluation Pattern: 50+50 = 100
|
Internal Assessment – 50% |
||
|
Periodical 1 |
Exam |
20% |
|
Periodical 2 |
Exam |
20% |
|
Continuous Assessment |
Assignment/Test/Quiz |
10% |
|
50% |
||
|
End Semester Examination- 50% |
||
|
Theory Exam |
50% |
|
|
|
|
50% |
|
Total |
100% |
|
Text book
Lewin’s Essential Genes, Jocelyn E. Krebs, Benjamin Lewin, Elliott S. Goldstein, Stephen T. Kilpatrick,Jones& Bartlett Publishers, 2013 – Science – 847 pages
References
Molecular Biology of the Gene, Seventh Edition, James D. Watson, Cold Spring Harbor Laboratory; Tania A. Baker, Massachusetts Institute of Technology; Alexander Gann, Cold Spring Harbor Laboratory; Michael Levine, University of California, Berkeley; Richard Losick, Harvard University,2013
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