Definition and scope: Origin and evaluation of pharmacoepidemiology need for pharmacoepidemiology, aims and applications.
Measurement of outcomes in pharmacoepidemiology
Outcome measure and drug use measures
Prevalence, incidence and incidence rate. Monetary units, number of prescriptions, units of drugs dis- pensed, defined daily doses and prescribed daily doses, medication adherence measurement
Concept of risk in pharmacoepidemiology: Measurement of risk, attributable risk and relative risk, time-risk relationship and odds ratio
Includes theoretical aspects of various methods and practical study of various methods with the help of case studies for individual methods
Drug utilization review, case reports, case series, surveys of drug use, cross – sectional studies, cohort studies, case control studies, case –cohort studies, meta – analysis studies, spontaneous reporting, pre- scription event monitoring and record linkage system.
Sources of data for pharmacoepidemiological studiesAd Hoc data sources and automated data systems.
Selected special applications of pharmacoepidemiology Studies of vaccine safety, hospital pharmacoepidemiology, pharmacoepidemiology and risk management, drug induced birth defects.
Definition, history, needs of pharmacoeconomic evaluations
Role in formulary management decisions
Outcome assessment and types of evaluation
Includes theoretical aspects of various methods and practical study of various methods with the help of case studies for individual methods:
Cost – minimization, cost- benefit, cost – effectiveness, cost utility