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Course Detail

Course Name Regenerative Medicine & Tissue engineering
Course Code 25SCR512
Program M. Sc. Stem Cell Technology and Regenerative Medicine
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

9 Lectures

Biologic and Molecular Basis for Regenerative Medicine: Current perspectives in Regenerative Medicine; Types of Tissues; Molecular organisation of cells; Extracellular Matrix; Cell-extracellular matrix interactions

Unit 2

9 Lectures

Cellular aspect of Regenerative Medicine: Stem cells and progenitors; Types of stem cells, Embryonic stem cells, induced pluripotent stem cells, Mesenchymal stem cells, Hematopoietic stem cells, Adult stem cells

Unit 3

12 Lectures

Different Stages of Tissue Regeneration: Basic cell structure and functions; Tissue organisation and functions; Organ structure and functions, Scar and Regeneration; Different stages of regeneration – Hemostasis, Inflammation, Proliferation, Angiogenesis, Remodelling; Case studies – Skin regeneration, Bone regeneration, Liver regeneration.

Unit 4

15 Lectures

Tissue Engineering: Relevance of tissue engineering; Triad of Tissue engineering – Scaffolds Types (Ceramics, Polymers, Composites Biomimetic scaffold); Cells, Growth factors; Case Studies: Ectoderm derived tissues (Nerve tissue, Cornea), Endoderm derived tissues (Liver, Pancreas), Mesoderm (Bone, Cartilage, Muscle, blood vessels, ligament, Tendon). Recent advances in biofabrication; 3D bioprinting

Introduction

Pre-requisites: Undergraduate level basic physics, chemistry and biology

Total number of classes: 45

Objectives and Outcomes

Course Outcomes:

Upon successful completion, students will have the

CO1. Understanding on the molecules and signalling pathways that regulate epithelial and mesenchymal states of tissues and cell-extracellular matrix interactions

CO2. Knowledge on the various types and sources of stem cells and their role in tissue growth, repair and regeneration

CO3. Knowledge on the inherent regenerative mechanisms in human body

CO4. Understanding on the fundamental aspects of tissue engineering and their application in developing various tissues.

Program Outcome 

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

3 = High Affinity, 2 = Medium Affinity, 1 = Low Affinity, – = No Affinity

C

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

3

1

1

–

1

1

–

–

–

–

–

2

CO 2

3

1

1

–

1

1

–

3

1

–

–

2

CO 3

3

1

2

3

1

1

–

1

1

–

–

2

CO 4

3

1

3

3

3

1

–

1

1

–

–

2

Program Specific Outcomes. (PSO)

PSO1. Demonstrate comprehensive knowledge of stem cell biology and their clinical and research relevance.

PSO2. Apply core laboratory techniques for stem cell isolation, characterization, and manipulation.

PSO3. Integrate principles of tissue engineering and biomaterials for regenerative applications.

PSO4. Analyze drug delivery, pharmacokinetics, and bioinformatics relevant to stem cell-based therapies.

PSO5. Evaluate ethical, regulatory, and translational aspects of stem cell product development.

PSO6. Bridge basic science with translational approaches in regenerative medicine and gene therapy.

PSO7. Design and interpret experimental strategies for stem cell-based disease

modelling and preclinical studies.

C

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

PSO7

C O

CO 1

3

–

3

–

–

2

–

CO 2

3

–

3

–

–

2

–

CO 3

–

–

3

2

–

2

–

CO 4

–

–

3

2

2

2

3

Evaluation Pattern

Evaluation Pattern: 50+50 = 100

Internal Assessment – 50% 
Periodical 1  Exam  20% 
Periodical 2  Exam  20% 
Continuous Assessment  Assignment/Test/Quiz 10% 
  50%
End Semester Examination- 50% 
Theory Exam  50%   
  50%
Total 100%

Textbook/ References

Textbook:

  •  Principles of Regenerative Medicine, Anthony Atala, Robert Lanza James, Thomson Robert Nerem, 2nd Edition, Elsevier -2010

References:

  • Ying Deng and Jordan Kuiper, Functional 3D Tissue Engineering Scaffolds: Materials, Technologies, and Applications (Woodhead Publishing Series in Biomaterials), 2017
  • Cato T. Laurencin, Lakshmi S. Nair. Nanotechnology and Regenerative Engineering: The Scaffold, Second Edition, CRC Press 2017

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