Unit 1
Lectures 8
Introduction: Introduction to carcinogenesis; Clonal origins of cancer, Experimental biology, Clinical data, Linking laboratory and clinic; Defining a neoplasm: Classifying cancers.
| Course Name | Cancer Biology |
| Course Code | 25SCR544 |
| Program | M. Sc. Stem Cell Technology and Regenerative Medicine |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
Lectures 8
Introduction: Introduction to carcinogenesis; Clonal origins of cancer, Experimental biology, Clinical data, Linking laboratory and clinic; Defining a neoplasm: Classifying cancers.
Lectures 8
Epidemiology: Descriptive epidemiology, Analytical epidemiology, Criteria required to establish causality, Biomarkers, Molecular epidemiology, Factors that influence human carcinogenesis; Chemical and radiation carcinogenesis: Chemical carcinogenesis, Radiation carcinogenesis.
Lectures 8
Growth: Cancer cells, Senescence, Cell mortality and telomerase, Apoptosis and cancer; Responding to the environment: General features, How a cell interacts with its environment, Hydrophobic growth regulatory molecules, Cross-talk between signaling pathways.
Lectures 8
Invasion and metastasis: Escape from local control and invasion, Intravasation, Transport in the bloodstream, Extravasation, Angiogenesis, Gene changes involved in metastasis.
Lectures 8
Crowd Control: Mechanisms of immune response to cancer, Tumour microenvironment, Pro- and anti-tumour activities in tumour microenvironment, How tumor cells evade from immune responses.
Lectures 5
Principles of cancer treatment: Principles behind the treatment of cancer, New forms of treatment; Approaches to cancer prevention.
Pre-requisites: Undergraduate level basic biology, chemistry and medical science
Total number of classes: 45
Course Outcome
CO1 To understand carcinogenesis, clinical connection and classification of cancers based on cellular origin
CO2 To understand the epidemiology of cancer including biomarkers and chemical and radiation-related origins of cancer
CO3 To learn about the connection between cell division, cell differentiation and apoptosis, and cancer.
CO4 To understand invasion of cancer cells and colonization at other sites in the body
CO5 To learn about tumour immunology, immune evasion of cancer cells and new forms of cancer therapy
Programme Outcomes (PO)
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
|
c |
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
C O |
||||||||||||
|
CO 1 |
3 |
3 |
3 |
3 |
2 |
2 |
3 |
0 |
0 |
0 |
0 |
3 |
|
CO 2 |
3 |
2 |
2 |
2 |
2 |
3 |
3 |
0 |
0 |
0 |
0 |
3 |
|
CO 3 |
3 |
2 |
2 |
2 |
3 |
3 |
3 |
0 |
0 |
0 |
0 |
3 |
|
CO 4 |
3 |
1 |
1 |
2 |
3 |
3 |
3 |
0 |
0 |
0 |
0 |
3 |
|
CO 5 |
3 |
3 |
3 |
3 |
2 |
3 |
3 |
0 |
0 |
0 |
0 |
3 |
0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity
Program Specific Outcomes. (PSO)
PSO1. Demonstrate comprehensive knowledge of stem cell biology and their clinical and research relevance.
PSO2. Apply core laboratory techniques for stem cell isolation, characterization, and manipulation.
PSO3. Integrate principles of tissue engineering and biomaterials for regenerative applications.
PSO4. Analyze drug delivery, pharmacokinetics, and bioinformatics relevant to stem cell-based therapies.
PSO5. Evaluate ethical, regulatory, and translational aspects of stem cell product development.
PSO6. Bridge basic science with translational approaches in regenerative medicine and gene therapy.
PSO7. Design and interpret experimental strategies for stem cell-based disease
modeling and preclinical studies.
|
C |
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
|
C O |
|||||||
|
CO 1 |
2 |
– |
1 |
– |
– |
2 |
– |
|
CO 2 |
– |
– |
– |
– |
– |
– |
|
|
CO 3 |
– |
– |
– |
– |
– |
2 |
– |
|
CO 4 |
– |
– |
– |
– |
– |
– |
– |
|
CO 5 |
– |
– |
– |
– |
– |
2 |
– |
Evaluation Pattern: 50+50 = 100
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/Test/Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% | |
Textbooks:
Reference
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