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Course Detail

Course Name Immunology
Course Code 25SCR541
Program M. Sc. Stem Cell Technology and Regenerative Medicine
Semester 2
Credits 3
Campus Kochi

Syllabus

Unit 1

3 lectures

Basic Concepts in Immunology, Cells and organs of the immune system, Principles of Innate and Adaptive Immunity

Unit 2

5 lectures

Innate Immunity: Recognition and effector mechanisms, Inflammation and its regulation, Complement system.

Unit 3

6 lectures

Adaptive Immunity: Antigen recognition and processing, B and T cell development and activation, Immune memory, Antigen Recognition by B-cell and T-cell Receptors

Unit 4

5 lectures

The Generation of Lymphocyte Antigen Receptors, the generation of diversity in immunoglobulins, T-cell receptor gene rearrangement, Structural variation in immunoglobulin constant regions.

Unit 5

6 lectures

The development and survival of Lymphocytes: Generation of lymphocytes in bone marrow and thymus, the rearrangement of antigen-receptor gene segments controls lymphocyte development, interaction with self-antigens selects some lymphocytes for survival but eliminates others, survival and maturation of lymphocytes in peripheral lymphoid tissues.

Unit 6

5 lectures

T cell-mediated immunity: Production of armed effector T cells, General properties of armed effector T cells, T cell-mediated cytotoxicity, Macrophage activation by armed CD4 TH1 cells.

Unit 7

5 lectures

Immunopathology: Autoimmunity, Allergy and hypersensitivity, Immunodeficiency disorders

Unit 8

5 lectures

Immunotherapy and Vaccines: Monoclonal Antibodies: Production and Applications, Adoptive Cell Therapy and Immunomodulation, Vaccine Development and Immunization Strategies, Currently available vaccines. Immunotherapy in Autoimmune Diseases and Cancer

Unit 9

5 Lectures

Immunological Diagnostics: Serological Techniques: ELISA, Western Blotting, Flow Cytometry and Immunophenotyping, Molecular Diagnostics in Immunology, Point-of-Care Testing in Immunodiagnostics

Introduction

Pre-requisites: Undergraduate level basic biology

Total number of classes: 45

Preamble

This course is designed to provide a comprehensive understanding of both fundamental and applied aspects of immunology. Successful completion of this course will foster a deep appreciation for the dynamic and multifaceted field of immunology, equipping the students with the knowledge and skills essential for both academic exploration and practical applications in various domains of science and medicine.

Objectives and Outcomes

CO1

Develop a comprehensive understanding of immunology by encompassing both innate and adaptive immune systems, focusing on fundamental concepts.

CO2

Recognize and understand the crucial cells and organs of the immune system, exploring their roles in immune responses.

CO3

To understand how innate and adaptive immunity work, applying their principles to bolster host defence

CO4

To learn about the mechanisms driving diversity in immunoglobulins and the rearrangement of T-cell receptor genes.

CO5

To learn about the intricate processes guiding the development and survival of lymphocytes, including their formation in the bone marrow and thymus.

CO6

To understand the humoral immune response, including B-cell activation, functions of immunoglobulin types, and how pathogens are destroyed through Fc receptors.

CO7

To understand the mechanisms underlying autoimmune conditions, allergies, hypersensitivity, and immunodeficiency disorders.

CO8

To acquire comprehensive knowledge in advanced immunological diagnostics, cutting-edge applications in immunotherapy and vaccines, insights into immunology’s role in infectious diseases, and an understanding of immune response manipulation.

Program Outcomes. (PSO)

PO1: Bioscience Knowledge

PO2: Problem Analysis

PO3: Design/Development of Solutions

PO4: Conduct Investigations of complex problems

PO5: Modern tools usage

PO6: Bioscientist and Society

PO7: Environment and Sustainability

PO8: Ethics

PO9: Individual & Team work

PO10: Communication

PO11: Project management & Finance

PO12: Lifelong learning

c

PO1

PO2

PO3

PO4

PO5

PO6

PO7

PO8

PO9

PO10

PO11

PO12

C O

CO 1

3

2

–

–

–

–

–

–

–

1

–

2

CO 2

3

2

–

–

–

2

–

–

–

–

–

2

CO 3

3

3

2

–

–

2

–

–

–

1

–

2

CO 4

3

3

2

2

–

–

–

–

–

–

–

2

CO 5

3

2

–

2

–

–

–

–

–

–

–

2

CO 6

3

2

–

–

–

–

–

–

–

–

–

2

CO 7

3

2

–

–

–

3

–

2

–

–

–

2

CO 8

3

3

2

3

3

3

–

2

1

1

–

3

0 – No affinity; 1 – low affinity; 2 – Medium affinity; 3 – High affinity

Program Specific Outcomes. (PSO)

PSO1. Demonstrate comprehensive knowledge of stem cell biology and their clinical and research relevance.

PSO2. Apply core laboratory techniques for stem cell isolation, characterization, and manipulation.

PSO3. Integrate principles of tissue engineering and biomaterials for regenerative applications.

PSO4. Analyze drug delivery, pharmacokinetics, and bioinformatics relevant to stem cell-based therapies.

PSO5. Evaluate ethical, regulatory, and translational aspects of stem cell product development.

PSO6. Bridge basic science with translational approaches in regenerative medicine and gene therapy.

PSO7. Design and interpret experimental strategies for stem cell-based disease

modeling and preclinical studies.

–

PSO1

PSO2

PSO3

PSO4

PSO5

PSO6

PSO7

C O

CO 1

–

–

–

–

–

2

–

CO 2

–

–

–

–

–

2

–

CO 3

–

–

–

–

–

2

–

CO 4

–

–

–

–

–

2

–

CO 5

–

–

–

–

–

2

–

CO 6

–

–

–

–

–

2

–

CO 7

–

–

–

–

–

2

–

CO 8

–

–

–

–

–

2

–

Evaluation Pattern

Evaluation Pattern: 50+50 = 100

Internal Assessment – 50% 
Periodical 1  Exam  20% 
Periodical 2  Exam  20% 
Continuous Assessment  Assignment/Test/Quiz 10% 
  50%
End Semester Examination- 50% 
Theory Exam  50%   
  50%
Total 100%

 

Textbook/ References

Textbook:

  1. Janeway’s Immunobiology, Ken Murphy, Paul Travers, Mark Walport, 9th edition.

References:

  1. Kuby Immunology” by Judy Owen, Jenni Punt, and Sharon Stranford , 2018
  2. Clinical Immunology: Principles and Practice” by Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., and Anthony J. Frew, 2018

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