Qualification: 
MSc, BSc
chandinip@am.amrita.edu
Phone: 
+91 9633692398/8589019329

Chandni currently serves as Junior Research Fellow at Amrita School of Biotechnology. She received her MSc in Microbiology from Amrita Vishwa Vidyapeetham in 2012. She is currently pursuing her PhD in Biotechnology at Phage Biology Lab.

 ALMA MATER

  • MSc Microbiology, Amrita Vishwa Vidyapeetham (2012)
  • BSc Microbiology, Manonmaniam Sundaranar University, Thirunelveli (2010)
     

AWARDS / HONOR

  • Awarded with Junior Research Fellowship from Amrita Vishwa Vidyapeetham.
  • Qualified GATE-Biotechnology, March 2012.

 

RESEARCH EXPERIENCE

The project entitled “Study on heterotrophic bacteria associated with the intertidal marine sponge Cinachyra allocladawas carried out under the Guidance of Dr. Shanta Achuthankutty, Chief Scientist, National Institute of Oceanography, Goa .

ONGOING RESEARCH PROJECT

Characterization of  binding of fibronectin and its fragments to different microbes/bacteriophages.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

Chandni P, Amrita Salim, Archana P. V., Pradeesh Babu, Dr. Bipin G. Nair, Madhavan, A., and Dr. Sanjay Pal, “Characterization of the bacteriophages binding to human matrix molecules.”, International Journal of Biological Macromolecules, 2017.[Abstract]


Recent literature has suggested a novel symbiotic relationship between bacteriophage and metazoan host that provides antimicrobial defense protecting mucosal surface by binding to host matrix mucin glycoproteins. Here, we isolated and studied different bacteriophages that specifically interact with human extracellular matrix molecules such as fibronectin, gelatin, heparin and demonstrated their potency for protection to host against microbial infections. We showed that subpopulations of bacteriophages that work against clinical isolates of Escherichia coli can bind to pure gelatin, fibronectin and heparin and reduced bacterial load in human colon cell line HT29. The bacteriophages were characterized with respect to their genome sizes, melting curve patterns and host tropism (cross-reactivity with different hosts). Since, the bacteriophages are non-toxic to the host and can effectively reduce bacterial load in HT29 cell line their therapeutic potency against bacterial infection could be explored.

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Faculty Research Interest: 
207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS