Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2001
Url : https://www.sciencedirect.com/science/article/pii/S0040403900018931?casa_token=KiQe2o3XRSsAAAAA:vrSu8LsgR952nh1oRLDZNAWEwWdkoYup-vQL6RcAyOWokROok9AQummVkzRL29mh4ZVgnvtl3HE
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2001
Abstract : Synthesis of a range of 1, 2, 4-triazolin-5-ones has been carried out by thermally induced
cyclization of 1-aryl/alkyl-2-alkyl isothiobiureas 4. The required isothiobiureas were
generated in situ by the reaction of alkyl halides with 1-aryl/alkyl-2-thiobiureas 3 in acidic
medium at reflux. The reaction proceeds after S-alkylation of the thiobiureas and is
demonstrated by the isolation of the alkyl isothiobiurea intermediates and their subsequent
acid catalyzed thermal cyclization.
Cite this Research Publication : M. M. Suni, Vipin A. Nair and C. P. Joshua, "Heterocyclization of 1-alkyl-2-thiobiureas with α-haloketones", Tetrahedron Letters 2001, 42, 97-99
