Publication Type:

Journal Article

Source:

World Journal of Pediatrics, Volume 7, Number 3, p.205-216 (2011)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-80054968175&partnerID=40&md5=8f5b487efa245dff4e3bd432069f715d

Keywords:

ablation therapy, Algorithms, amnion fluid, antibiotic agent, arterial gas, article, Biochemistry, bladder distension, bladder dysfunction, bladder obstruction, child, clinical feature, creatinine, creatinine blood level, cystostomy, cystourethrography, disease classification, disease severity, echography, embryo development, embryology, fertility, follow up, gestational age, human, Humans, hydronephrosis, infant, kidney, kidney dysplasia, kidney function, kidney scintiscanning, kidney transplantation, lung hypoplasia, male, micrognathia, micturition cystourethrography, newborn, newborn care, obstructive uropathy, oligohydramnios, outcome assessment, pathology, pathophysiology, prenatal diagnosis, Prognosis, Sepsis, succimer, uremia, urethra, urethra disease, urethra stricture, urethra valve, urethral catheterization, urinary diversion, urinary tract disease, urinary tract infection, urine culture, Urogenital Abnormalities, Urologic Diseases, vesicoureteral reflux

Abstract:

Background: Posterior urethral valve (PUV) is a significant cause of morbidity, mortality and ongoing renal damage in children. It accounts for end-stage renal disease in a proportion of children. This article aims at highlighting the current trend in the management of boys with posterior urethral valve. Data sources: PubMed/Medline and bibliographic search for posterior urethral valve was done. Relevant literatures on presentation, pathology, evaluation, management and outcomes of PUV were reviewed. Results: PUV which is increasingly diagnosed prenatally presents a spectrum of severity. The varied severity and degree of obstruction caused by this abnormality depend on the configuration of the obstructive membrane within the urethra. The decision to intervene prenatally is dependent on gestational age, amniotic volume, and renal function of fetal urine aspiration. Identification of the patients who may benefit from early intervention remains inconclusive. Endoscopic ablation of the valve is the gold standard of treatment but use of Mohan's valvotome and other modalities are invaluable in developing countries where endoscopic facilities are limited. Proximal urinary diversion may result in poor bladder compliance and should be reserved for patients with persisting or increasing upper urinary tract dilatation, increasing serum creatinine or inappropriate instruments. The behavior of the bladder and its subsequent management after valve ablation may infl uence the long-term renal outcome in PUV patients. Conclusions: The care of children with PUV continues to improve as a result of earlier diagnosis by ultrasound, developments in surgical technique and meticulous attention to neonatal care. The ultimate goal of management should be to maximize renal function, maintain normal bladder function, minimize morbidity and prevent iatrogenic problems. © Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2011. All rights reserved.

Notes:

cited By (since 1996)7

Cite this Research Publication

A. Aa Nasir, Ameh, E. Ab, Abdur-Rahman, L. Oa, Adeniran, J. Oa, and Abraham, M. Kc, “Posterior urethral valve”, World Journal of Pediatrics, vol. 7, pp. 205-216, 2011.