Unit 1
Introduction to disease pathogenesis, clinical terminologies, concept of prognosis, evidence-based treatment approach, bench-to-bedside approach in medicine, and introduction to a holistic approach in treating diseases
| Course Name | Molecular Basis of Disease |
| Course Code | 24MMD541 |
| Program | M. Sc. Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Faridabad, Kochi |
Introduction to disease pathogenesis, clinical terminologies, concept of prognosis, evidence-based treatment approach, bench-to-bedside approach in medicine, and introduction to a holistic approach in treating diseases
The process of growth, differentiation and cell death and its molecular organization in cellular homeostasis and diseases such as cancer, neurodegenerative diseases and diabetes. Significance of molecular changes in controlling a normal homeostasis condition compared to disease.
Pathological changes in diseases such as cancer, neurodegenerative diseases, autoimmune diseases and diabetes. The role of molecules and molecular changes in the pathological manifestation of disease.
Significance of environmental chemicals in modifying normal homeostasis and leading to pathological changes at molecular level by controlling different signaling mechanisms. Significance of epidemiology, etiology in pathogenesis of diseases
Inflammation in normal and pathological state. Molecular mechanisms driving the immunopathology in cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Interdependence of molecular pathways in controlling homeostasis and disease pathology
How the molecular changes can be targeted to reverse the pathology and the contribution of drugs in this respect cancer, neurodegenerative diseases, autoimmune diseases and diabetes.
DNA modifications and mutations in diseases and its significance in the pathology associated with cancer, neurodegenerative diseases, autoimmune diseases and diabetes. Role of environment in (lifestyle) in modifying DNA and the molecular landscape associated with homeostasis and disease in cancer, neurodegenerative diseases, autoimmune diseases and diabetes.
Pre-requisites: Basic understanding of biology and biochemistry
Total number of classes: 45
Preamble: This course is primarily designed to help students understand the molecular mechanism behind disease processes. The idea is to use specific examples of disease conditions that are globally prevalent and effects large populations worldwide. These chosen diseases will be used to study and understand disease manifestation, progress, and outcome, based on molecular mechanisms at the tissue and cellular level. This course utilizes an active learning strategy where students and the instructor will discuss recent developments in molecular pathogenesis of the specific diseases, based on published articles.
Course Outcome
CO1: To demonstrate ability to approach a scientific report in a systematic manner
CO2: To be able to identify scientific hypothesis and understand the rationale behind the research approach in a scientific report
CO3: Be able to summarize disease pathogenesis and connect it to clinical signs and symptoms associated with the disease
CO4: Be able to work with team and put together in depth information related to disease mechanism at the cellular and molecular level, treatment options and current developments in the field
CO5: Be able to give a presentation related to molecular basis of a disease and field audience questions related to the topic
Programme Outcomes (PO) (As given by NBA and ABET)
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
|
PO1 |
PO2 |
PO3 |
PO4 |
PO5 |
PO6 |
PO7 |
PO8 |
PO9 |
PO10 |
PO11 |
PO12 |
|
|
CO1 |
2 |
3 |
1 |
– |
– |
– |
– |
– |
3 |
3 |
– |
3 |
|
CO2 |
1 |
3 |
1 |
– |
– |
2 |
– |
3 |
3 |
3 |
– |
3 |
|
CO3 |
3 |
2 |
1 |
3 |
– |
– |
– |
– |
3 |
3 |
– |
3 |
|
CO4 |
2 |
3 |
3 |
2 |
3 |
3 |
– |
2 |
3 |
3 |
1 |
3 |
|
CO5 |
1 |
1 |
3 |
2 |
1 |
2 |
– |
– |
3 |
3 |
– |
3 |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular dysregulation in diseases
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
|
PSO1 |
PSO2 |
PSO3 |
PSO4 |
PSO5 |
PSO6 |
PSO7 |
PSO8 |
PSO9 |
PSO10 |
|
|
CO1 |
1 |
1 |
– |
– |
– |
– |
– |
– |
– |
– |
|
CO2 |
– |
– |
2 |
2 |
2 |
1 |
– |
2 |
– |
– |
|
CO3 |
3 |
3 |
3 |
3 |
3 |
3 |
1 |
1 |
1 |
– |
|
CO4 |
3 |
3 |
3 |
3 |
3 |
3 |
1 |
1 |
1 |
– |
|
CO5 |
3 |
3 |
3 |
3 |
3 |
1 |
1 |
3 |
– |
– |
Evaluation Pattern: 50+50 = 100
|
Internal Assessment – 50% |
||
|
Periodical 1 |
Exam |
20% |
|
Periodical 2 |
Exam |
20% |
|
Continuous Assessment |
Assignment/Test/Quiz |
10% |
|
50% |
||
|
End Semester Examination- 50% |
||
|
Theory Exam |
50% |
|
|
50% |
||
|
Total |
100% |
|
Robbins Basic Pathology, 9th edition, Kumar, Abbas, Fausto and Mitchell; Saunders, Publication, ISBN-13: 978-1437717815. ]
Selected research articles will be provided before each class
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