| Course Name | Drug Delivery, Pharmacokinetics & Pharmacodynamics |
| Course Code | 24MM641 |
| Program | M. Tech. in Molecular Medicine(MLM) |
| Semester | 2 |
| Credits | 3 |
| Campus | Kochi |
This course introduces the student to basic principles of pharmacokinetics and pharmacodynamics, along with an introduction to the main drug categories. The central focus of this course is to help students understand how concentration of a drug changes in various body compartments and the factors regulating that change. Students will also be exposed to topics related to the mechanisms of drug action, with suitable and appropriate examples.
Fundamental concepts of drug delivery: Physicochemical Properties of Drugs, Effects of fundamental physicochemical properties on the biopharmaceutical behavior of drugs, Concentration-time curve of pharmacokinetics; Fundamentals of controlled drug delivery, Pharmacokinetic and pharmacodynamic basis of controlled drug delivery, Physicochemical and biological factors influencing design and performance of controlled release products
Routes of Drug Delivery: Enteral – Oral, Sublingual, Buccal, Rectal; Parenteral – Intravenous, Intramuscular, Intra-arterial, Intra-thecal, Intradermal; Topical – Transdermal, Intranasal, Conjuctival; Conventional drug delivery systems; Concept of active and passive targeting of drugs
Introduction to pharmacokinetics; Route of administration of drugs; Pharmacokinetic Parameters – bioavailability, biological Half-life, volume of distribution and clearance; Absorption of drugs; Mechanism of drug absorption; Factors affecting drug absorption; Distribution of drugs; Protein binding of drugs; Factors affecting distribution of drugs; Metabolism of drugs; Excretion of drugs; Kinetic models
Introduction to pharmacodynamics, drug-receptor interaction, body compartment systems, Drug Action – Action and effect, Excitation and Inhibition, Selectivity of drug action, Therapeutic effect and adverse reaction, Principles of Drug action- Dose effect relationship, Time effect relationship, structure activity relationship,Mechanism of drug action- Simple physical and chemical property, involving or interfering physiological and biochemical process of living system.
Pre-requisites: Basic level biology and biochemistry
Total number of classes: 45
Course Outcome
CO1: Be able to articulate the drug-intrinsic and extrinsic factors that determine drug molecule movement across biological membranes
CO2: To demonstrate understanding in concepts that determine dosage, absorption, distribution, and excretions of drugs, along with model systems connected with these concepts and apply pharmacokinetic principles to explain variation in drug disposition
CO3: To demonstrate ability to describe functional outcome of drugs due to drug-cell interactions
CO4: To demonstrate understanding of signaling pathways that link drug-receptor interaction and cell response, along with an understanding of toxicological response and ways to quantify and describe drug-induced toxic effects
CO5: Be able to work with a team and put together in depth information related to PKPD concepts in a web-platform
Programme Outcomes (PO) (As given by NBA and ABET)
PO1: Bioscience Knowledge
PO2: Problem Analysis
PO3: Design/Development of Solutions
PO4: Conduct Investigations of complex problems
PO5: Modern tools usage
PO6: Bioscientist and Society
PO7: Environment and Sustainability
PO8: Ethics
PO9: Individual & Team work
PO10: Communication
PO11: Project management & Finance
PO12: Lifelong learning
| PO1 | PO2 | PO3 | PO4 | PO5 | PO6 | PO7 | PO8 | PO9 | PO10 | PO11 | PO12 | |
| CO1 | 3 | 1 | – | – | – | – | – | – | 3 | – | – | – |
| CO2 | 3 | 3 | 2 | 3 | – | – | 2 | – | 3 | – | – | – |
| CO3 | 3 | 3 | 2 | – | – | – | – | – | 3 | – | – | – |
| CO4 | 3 | 2 | – | – | – | – | – | – | 3 | – | – | – |
| CO5 | 2 | 1 | – | – | 3 | 2 | – | 3 | 3 | 2 | – | – |
Program Specific Outcomes. (PSO)
PSO 1 – Biochemical organization and cellular complexity in function
PSO 2 – Biomolecules in Medicine
PSO 3 – Molecular dysregulation in diseases
PSO 4 – Molecular technology in diagnosis and therapy
PSO 5 – Cell based approaches in diagnosis and therapy
PSO 6 – Microorganisms in Medicine
PSO 7 – Nanoscale entities and its significance in Medicine
PSO 8 – Tissue architecture engineering in Medicine
PSO 9 – Compounds as drugs and its efficacy
PSO 10 – Bioinformatics and biological data use
| PSO1 | PSO1 | PSO2 | PSO3 | PSO4 | PSO5 | PSO6 | PSO7 | PSO8 | PSO9 | PSO10 | |
| CO1 | 3 | – | – | – | 2 | – | – | – | 3 | – | |
| CO2 | 3 | – | – | – | – | – | – | – | 3 | – | |
| CO3 | 3 | 1 | 1 | – | 2 | – | – | – | 3 | – | |
| CO4 | 3 | 1 | 1 | – | – | 2 | – | – | 3 | 1 | |
| CO5 | 1 | 1 | 1 | – | 1 | – | – | – | 2 | – |
| Internal Assessment – 50% | ||
| Periodical 1 | Exam | 20% |
| Periodical 2 | Exam | 20% |
| Continuous Assessment | Assignment/Test/Quiz | 10% |
| 50% | ||
| End Semester Examination- 50% | ||
| Theory Exam | 50% | |
| 50% | ||
| Total | 100% |
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