Syllabus
1. Organic preparations: Recrystallisation and determination of melting point and its importancemay be mentioned (a) Acetylation: Preparation of acetanilide from aniline (b) Oxidation: Preparation of benzoin acid from benzaldehyde(c) Nitration: Preparation of m-dinitrobenzene from benzene(d) Hydrolysis: preparation of benzoic acid from ethyl benzoate 2. Quantitative organic analysis (Any four)(a) Estimation of aniline by bromate-bromide method(b) Estimation of glucose by Fehlings method(c) Determination of iodine value of an oil by Vijs method(d) Determination of saponification value of an ester / oil (e) Estimation of amino acid by formal titration method(f) Estimation of ascorbic acid in Vitamin C tablets by Volumetry(g) Estimation of Paracetamol by titrimetric and photo spectrometric methods.(h) Gravimetric Analysis of Lead, Iron and Nickel3. Chromatographic Techniques (Any two)(a) Thin Layer Chromatography (i) Determination of Rf values and identification of organic compounds: (b) Separation of green leaf pigments (spinach leaves may be used)(c) Separation of mixture of dyes (ii) Paper Chromatography Determination of Rf values and identification of organic compounds. (iii) Column Chromatography: Separation of ortho and para nitroanilines
Objectives and Outcomes
OBJECTIVES: To train the students and provide then necessary expertise in carrying out basic organic synthesis and to characterize and confirm the purity of the products through analytical techniques.
Course Outcome:
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Demonstrate the experimental procedure for important organic preparations and determination of melting point of organic compounds.
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Apply experimental techniques for the quantitative estimation of the properties of organic compounds.
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Apply various chromatographic approaches for separation and identification of components of a mixture.
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Text Books / References
TEXTBOOKS / REFERENCES:1) E. Stocchi: Industrial Chemistry, Vol -I, Ellis Horwood Ltd. UK.2) P.C. Jain, M. Jain: Engineering Chemistry, Dhanpat Rai & Sons, Delhi.3) B.K. Sharma: Industrial Chemistry, Goel Publishing House, Meerut.4) G.L. Patrick: Introduction to Medicinal Chemistry, Oxford University Press, UK.5) Hakishan, V.K. Kapoor: Medicinal and Pharmaceutical Chemistry, Vallabh Prakashan, Pitampura, New Delhi.6) R. Cremlyn: Pesticides, John Wiley.7) William O. Foye, Thomas L., Lemke , David A. William: Principles of Medicinal Chemistry, B.I. Waverly Pvt Ltd. New Delhi.
