Course

Unit I IntroductionThe disconnection approach, designing a synthesis, FGI, synthons, order of events, choosing adisconnection, synthesis of aromatic compounds, Chemoselectivity in synthesis One group CX disconnections alcohols, ethers, sulphides, alkyl halides, Two group C-X disconnections 1,1-, 1,2- and 1,3-difunctionalozed compounds. protection and deprotection of functional group including C-C multiple bondsUnit II C-C bond formations and disconnections Reversal of polarity, protecting groups in synthesis, cyclisation and radical reactions, amine synthesis, 1,1 and 1,2 C-C disconnections, synthesis of alcohols, carbonyl compounds and carboxylic acids, synthesis of other compounds from alcohols, carbonyl compounds by one group C-C disconnections, enolate chemistry.Unit III Two group disconnectionsDiels-Alder reactions, 1,3-difunctionalized and ?, ?-unsaturated carbonyl compounds, base catalysed reactions, 1,5-difunctionalized compounds, Michael addition and Robinson annulations, 1,2-difunctionalized compounds, methods using acyl anion equivalents, 1,4- and 1,5-difunctionalized reactions, reconnections,.Unit IV Ring synthesisThree, four and five membered ring synthesis and retrosynthesis, pericyclic reactions for ring synthesis, radical and photochemical reactions, six membered rings, aromatic heterocycles, aromatic heterocycles with two heteroatoms, rearrangements in synthesis, electrophilic substitution reactions, named reactions in heterocyclic synthesis.Unit V Retrosynthesis in actionAdvanced strategies, retrosynthesis in industry, stereoselectivity and regioselectivity in synthesis, using alkenes, alkynes and nitro compounds in synthesis, retrosynthetic analysis and synthesis practice problems. Seminar

Text Books:1. Organic Synthesis The disconnection approach by Stuart Warren, John Wiley and Sons,2004.2. Organic Chemistry by Clayden, Greeves, Warren and Wothers, Oxford University press, 2001.References:1. R. O. C. Norman, Principles of Organic Synthesis, Chapman and Hall 2nd Edition, 1995.2. Jerry March, Advanced Organic Chemistry, Wiley Interscience, 2001.