Publication

Abstract : Alendronate is frequently prescribed among bisphosphonates for managing a range of conditions like osteoporosis, Paget's disease, and other bone-related disorders. By preventing bone resorption, it boosts bone density and lowers the chance of fractures. However, long-term alendronate use may be linked to possible side effects such as oesophageal ulcers, gastrointestinal irritation, and extremely rare cases of atypical femoral fractures and osteonecrosis of the jaw. Alendronate is still frequently prescribed for the treatment of osteoporosis and is regarded as a significant therapeutic option for enhancing bone health and lowering the risk of fracture despite these hazards. To overpower the limitations pertaining to the conventional administration of alendronate, many researchers have explored and developed formulations for delivering alendronate via controlled drug delivery systems. This review paper explores different formulations including hydrogels, transdermal formulations, microspheres, implants, and nanoparticles, devised to administer alendronate in a controlled manner, aiming to tackle the hindrances corresponding to traditional alendronate delivery strategies. In a pursuit to identify the best available formulation, an exhaustive literature survey was conducted, and a comprehensive review of the various formulations that have been developed to deliver alendronate in a controlled manner, was done.