Publication

Abstract : Shireeshadi choornam, a topical fine powder, has been described in Ayurveda traditional textbooks as an effective formulation for treating Primary hyperhidrosis (PHH). This formulation shows great potential in alleviating excessive sweating and unpleasant body odors. The symptoms of PHH include excessive sweating on the palms, underarms, soles, and face. However, there is limited research available on the physicochemical and phytochemical analysis of Shireeshadi formulation. In this study, we aimed to investigate the physicochemical and phytochemical characteristics of two variations of Shireeshadi choornam: one without talc (SFP) and the other with talc (SFPWT). Both samples underwent LCMS QTOF analysis. However, only the SFPWT sample underwent physicochemical analysis. The LCMS analysis of both SFP and SFPWT revealed the presence of nine bioactive phytochemical metabolites, namely Harman, alpha-Bergamotenol, beta-Santalene, beta-Bisabolol, alpha-Curcumene, 3-Butylpyridine, alpha-Bergamotene, Prococene II, and alpha-Eudesmol. Upon reviewing the effects of these bioactive phytochemicals, it was found that they can help reduce the symptoms and complications of PHH by blocking the muscarinic receptors on the sweat glands. Additionally, these phytochemicals possess antifungal and antibacterial properties.