• Endovascular stents, used commonly for the treatment of occlusive vascular diseases, have historically been manufactured using metals and metal composites. Although stents have reduced the restenosis rate from 40% to 20% compared to angioplasty alone, in-stent restenosis still remains a major limitation for this approach.

    nanosurface-engineering-of-bare-metallic-coronary-stents-for-combating-in-stent-restenosis
  • Manganese dioxide (MnO2) is a technologically important material and has been extensively studied due to its potential uses in non-volatile memory devices, gas sensors and batteries. The construction of aligned ensembles of these metal oxide nanostructures as electrodes could advance their existing potential in supercapacitor applications.

    nano-fibre-scaffold-electrodes-based-on-mn02-and-polymer-carbon-composites-for-high-performance-storage-device
  • This project proposes to develop novel natural biopolymeric composite hydrogel bandages based alginate, chitin and chitosan with antibacterial Herb Hemigraphis Ulternata/ZnO nanoparticles. This three-year project will involve preparation and characterization of nanostructured hydrogel bandages followed by in-vitro protein adsorption, antibacterial, blood clotting, cell attachment and proliferation.

    development-of-natural-biopolymeric-hydrogel-bandages-with-nanozno-nanosuspensions-of-herb-hemigraphis-ulternata-for-wound-dressing
  • This project aims to develop a synergistic collaboration between an active nanomedicine team from the Faculty of Pharmacy, University of Porto, Portugal and a strong nano medicine group at the Amrita Center for Nanosciences, AIMS, Kochi, India. The broad area of this targeted nanomedicine research is lung cancer, which is a very serious disease in both the collaborating countries.

    novel-targeted-chitosan-based-therapeutic-polymeric-nanomedicines-for-lung-cancer-applications
  • The project on novel target-specific multiplexed nanophytomedicines for cancer therapy, funded by ICMR, focuses on the importance of dietary phytochemicals in sensitizing breast cancers that are resistant to chemodrugs such as Paclitaxel in clinical use.

    novel-target-specific-multiplexed-nano-phytomedicines-for-cancer-therapy
  • This three-year project involves preparation of nanostructured scaffolds, plasma treatment of the scaffolds, followed by in-vitro protein adsorption, cell attachment and proliferation with and without plasma treatment.

    plasma-surface-modification-of-nanostructured-surfaces-of-marine-based-scaffolds-and-membranes-for-enhanced-bioactivity
  • The tumour hierarchical model proposes origin of cancer from a small population of cells having properties of stemness like self renewal and pluripotency. Although, cancer stem cells (CSCs) have been identified in leukemia and solid tumours by surface markers, there is variability in their specificity for isolation of CSCs in a specific tumour.

    biology-of-cancer-stem-cells-2
  • This project has been developing nanostructured thin film electrical storage materials with high surface area and storage capacity. A range of nanomaterials is being investigated, such as, nanocarbon, metal oxides and on variety of processing techniques & deposition methods.

    combining-solar-cells-with-supercapacitors-and-batteries-integrated-nanomaterial-based-photovoltaic-storage-devices
  • This center established in 2008 with funding from DST to develop a high efficiency solar cell based on the use of nanostructured electrodes and a dye sensitized approach. Currently this research involves a combination of the use of organic and dye sensitized approaches to improve the efficiency and reduce the cost of the solar cells.

    center-for-excellence-on-integrated-nanomaterial-based-photovoltaic-storage-devices
  • Drug discovery is currently in an exciting phase where conventional methodologies are being ably complemented by ‘omics’ approaches due, in part, to the greater accessibility of the newest generation of high-throughput platforms and technologies. At the Cancer Discovery Biology Laboratory, work is done towards making the identification of oncology clinical biomarkers more feasible through state-of-the-art pharmacogenomic and proteomic techn

    cancer-discovery-biology
  • This project provides mobility funding for joint facility utilisation visits between ACNS and University of Zurich on the project entitled, “Anti-cancer Applications of Chitosan and Polyoxometalate Nanocomplexes”.

    joint-utilization-of-advance-facility-juaf-program-isjrp-indo-swiss
  • The current study will enable the elucidation of global miRNA expression profiles and identification of miRNA targets in response to intervention with chemopreventive phytochemicals in liver cancer. This will enable a better understanding of miRNA dysregulation and identify novel biomarkers for preventive or therapeutic intervention in liver cancer.

    modulation-of-microrna-and-protein-signatures-in-hepatocellular-carcinoma-by-chemopreventive-phytochemicals

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