'Clinical Pharmacokinetics & Pharmacotherapeutic Drug Monitoring' is a course offered in the fifth year of Pharm. D. program at School of Pharmacy, Health Sciences campus, Amrita Vishwa Vidyapeetham.
Drug monitoring (Theory)
Course Duration: 2 Hrs./Week
- Introduction to Clinical pharmacokinetics.
- Design of dosage regimens:
Nomograms and Tabulations in designing dosage regimen, Conversion from intravenous to oral dosing, Determination of dose and dosing intervals, Drug dosing in the elderly and pediatrics and obese patients.
- Pharmacokinetics of Drug Interaction:
- Pharmacokinetic drug interactions
- Inhibition and Induction of Drug metabolism
- Inhibition of Biliary Excretion.
- Therapeutic Drug monitoring:
- Individualization of drug dosage regimen (Variability – Genetic, Age and Weight , disease, Inter- acting drugs).
- Indications for TDM. Protocol for TDM.
- Pharmacokinetic/Pharmacodynamic Correlation in drug therapy.
- TDM of drugs used in the following disease conditions: cardiovascular disease, Seizure disorders, Psychiatric conditions, and Organ transplantations.
- Dosage adjustment in Renal and hepatic Disease.
- Renal impairment
- Pharmacokinetic considerationsClinical research associate
- General approach for dosage adjustment in Renal disease.
- Measurement of Glomerular Filtration rate and creatinine clearance.
- Dosage adjustment for uremic patients.
- Extracorporeal removal of drugs.
- Effect of Hepatic disease on pharmacokinetics.
- Population Pharmacokinetics.
- Introduction to Bayesian Theory.
- Adaptive method or Dosing with feed back.
- Analysis of Population pharmacokinetic Data.
- Genetic polymorphism in Drug metabolism: Cytochrome P-450 Isoenzymes.
- Genetic Polymorphism in Drug Transport and Drug Targets.
- Pharmacogenetics and Pharmacokinetics/Pharmacodynamic considerations