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Dr. Manoj Bhat K.

Assistant Professor,School of Artificial Intelligence, Coimbatore

Qualification: MSc, Ph.D
k_manojbhat@cb.amrita.edu
Research Interest: Genomics, Proteomics, Metabolomics, Computational Biology

Bio Publications Experience/Qualification Positions Teaching GIAN/Workshops/Short-term Training Programs Attended Miscellaneous
Bio

Dr. Manoj Bhat K. currently serves as an Assistant Professor at School of Artificial Intelligence, Coimbatore campus.

During my tenure at Manipal School of Life Sciences, Manipal Academy of Higher Education, I engaged in a wide range of academic and research activities. These included: a) implementing a Computational Biology module for the BSc program and coordinating the MSc program in Bioinformatics; b) managing dissertation projects for both BSc and MSc students; c) assisting faculty with the computational aspects of their research; and d) pursuing my PhD, which I completed in 2024 with a focus on “Systems Biology of the One Carbon Pathway.” My doctoral research involved designing and evaluating a mathematical model for a one-carbon metabolic pathway based on reaction kinetics and developing systems biology-based genomic confounding variables through contiguous flux analysis. Additionally, I curated the 1CMDb database, an online interactive tool intended for study, text mining, and informatics analysis. My research led to several published manuscripts in peer-reviewed journals. My undergraduate and postgraduate projects encompassed gene expression studies, microarray data analysis, NGS and omics technologies, and database construction. I have developed strong analytical, relationship management, problem-solving, and leadership skills, along with effective communication abilities.

Publications

Journal Article

Year : 2023

Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s)

Cite this Research Publication : Sima Chaudhari, Akshay Pramod Ware, Dushyanth Babu Jasti, Sankar Prasad Gorthi, Lavanya Prakash Acharya, Manoj Bhat, Sandeep Mallya, Kapaettu Satyamoorthy, Exome sequencing of choreoacanthocytosis reveals novel mutations in VPS13A and co-mutation in modifier gene(s), Molecular Genetics and Genomics, Springer Science and Business Media LLC, 2023, https://doi.org/10.1007/s00438-023-02032-2

Publisher : Springer Science and Business Media LLC

Year : 2022

Identification of potent HDAC 2 inhibitors using E-pharmacophore modelling, structure-based virtual screening and molecular dynamic simulation

Cite this Research Publication : Padmini Pai, Avinash Kumar, Manasa Gangadhar Shetty, Suvarna Ganesh Kini, Manoj Bhat Krishna, Kapaettu Satyamoorthy, Kampa Sundara Babitha, Identification of potent HDAC 2 inhibitors using E-pharmacophore modelling, structure-based virtual screening and molecular dynamic simulation, Journal of Molecular Modeling, Springer Science and Business Media LLC, 2022, https://doi.org/10.1007/s00894-022-05103-0

Publisher : Springer Science and Business Media LLC

Year : 2019

Evidence for perturbed metabolic patterns in bipolar disorder subjects associated with lithium responsiveness

Cite this Research Publication : Manjunath B Joshi, Supriya Pai, Aswath Balakrishnan, Manoj Bhat, Ananthpadmanabha Kotambail, PSVN Sharma, Kapaettu Satyamoorthy, Evidence for perturbed metabolic patterns in bipolar disorder subjects associated with lithium responsiveness, Psychiatry Research, Elsevier BV, 2019, https://doi.org/10.1016/j.psychres.2019.01.031

Publisher : Elsevier BV

Year : 2018

In silico characterization of functional single nucleotide polymorphisms of folate pathway genes

Cite this Research Publication : Manik Vohra, Anu Radha Sharma, Bobby Paul, Manoj K Bhat, Kapaettu Satyamoorthy, Padmalatha S. Rai, In silico characterization of functional single nucleotide polymorphisms of folate pathway genes, Annals of Human Genetics, Wiley, 2018, https://doi.org/10.1111/ahg.12231

Publisher : Wiley

Year : 2017

1-CMDb: A Curated Database of Genomic Variations of the One-Carbon Metabolism Pathway

Cite this Research Publication : Manoj K. Bhat, Veerendra P. Gadekar, Aditya Jain, Bobby Paul, Padmalatha S. Rai, Kapaettu Satyamoorthy, 1-CMDb: A Curated Database of Genomic Variations of the One-Carbon Metabolism Pathway, Public Health Genomics, S. Karger AG, 2017, https://doi.org/10.1159/000475805

Publisher : S. Karger AG

Year : 2014

Mitochondrial DNA variation analysis in cervical cancer

Cite this Research Publication : Shama Prasada Kabekkodu, Samatha Bhat, Roshan Mascarenhas, Sandeep Mallya, Manoj Bhat, Deeksha Pandey, Pralhad Kushtagi, Kumarasamy Thangaraj, P.M. Gopinath, Kapaettu Satyamoorthy, Mitochondrial DNA variation analysis in cervical cancer, Mitochondrion, Elsevier BV, 2014, https://doi.org/10.1016/j.mito.2013.07.001

Publisher : Elsevier BV

Year : 2014

Genetic association of KCNJ10 rs1130183 with seizure susceptibility and computational analysis of deleterious non-synonymous SNPs of KCNJ10 gene

Cite this Research Publication : Nagaraja M. Phani, Shreeshakala Acharya, Seethu Xavy, Nalini Bhaskaranand, Manoj K. Bhat, Aditya Jain, Padmalatha S. Rai, Satyamoorthy Kapaettu, Genetic association of KCNJ10 rs1130183 with seizure susceptibility and computational analysis of deleterious non-synonymous SNPs of KCNJ10 gene, Gene, Elsevier BV, 2014, https://doi.org/10.1016/j.gene.2013.12.026

Publisher : Elsevier BV

Year : 2014

Genome Sequences of Four Clinical Staphylococcus aureus Strains with Diverse Drug Resistance Profiles Isolated from Diabetic Foot Ulcers

Cite this Research Publication : Thokur Sreepathy Murali, Bobby Paul, Hersh Parikh, Rana Pratap Singh, Shettigar Kavitha, Manoj K. Bhat, Kapaettu Satyamoorthy, Genome Sequences of Four Clinical Staphylococcus aureus Strains with Diverse Drug Resistance Profiles Isolated from Diabetic Foot Ulcers, Genome Announcements, American Society for Microbiology, 2014, https://doi.org/10.1128/genomea.00204-14

Publisher : American Society for Microbiology

Experience/Qualification

13 years in teaching and research (Manipal Life Sciences, Manipal Academy of Higher Education, Manipal)

Qualification

  • 2018-2023 : Ph. D.
    Specialization:     Bioinformatics
    Thesis title: Systems Biology of One Carbon Pathway
  • 2005-2007 : MSc
    Specialization:     Bioinformatics
    Thesis title: Support Vector Machine (SVM) & Hidden Markov Model in Bioinformatics (HMM) andits Applications at Centre for Excellence in Computational Engineering and Networking(CEN), Amrita Vishwa Vidyapeetham Ettimadai Coimbatore
Positions

Current Positions

  • Assistant Professor (2025-) 

Past Positions :

  • Faculty Associate (2024-2025)
  • Senior Grade Lecturer (2009-2022)
Teaching

Courses Taught

  • Bioinformatics
  • Computational Biology
  • Linux
GIAN/Workshops/Short-term Training Programs Attended
  1. Resource person at the “Hands-on Workshop on Basics of Computational Biology” held on May 3 & 4, 2024, organized by SDM Research Institute for Biomedical Sciences (SDMRIBS), Sri Dharmasthala Manjunatheshwara University, Dharwad.
  2. Participated in IP Awareness/Training program under the National Intellectual Property Awareness Mission on April 27, 2022, organized by Intellectual Property Office India.
  3. Annual Meeting/Symposium Society of Biological Chemists (India) – Coastal Karnataka Chapter – during the years 2013-2018 organized by Manipal School of Life Sciences, MAHE,Manipal.
  4. Participated as a resource person (20/06/2014) in the seminar on the theme “Management of Innovative Drug Development” sponsored by AICTE under the Quality Improvement Programme as a part of the Continuing Pharmacy Education Council (CPEC) held from 16th June 2014 to 28th June 2014 organized by Manipal College of Pharmaceutical Sciences, MAHE, Manipal.
  5. Participated in a five-day workshop on “iOMICSTM – NGS Data Analysis Training Course” held on 27-31, May 2013 at InterpretOmics India Pvt.Ltd., Bangalore India.
  6. Participated in “Medical Image Processing Application Development Using Open-Source Platforms ITK/VTK” on 18th and 19th February 2012, held at the School of Information Sciences MAHE, Manipal.
  7. Participated in the workshop on “Protein Structure Function and Folding” held during the period from December 20-24, 2010 at the Indian Institute of Science, Bangalore, organized by IISc Mathematics Initiative (IMI).
  8. Participated in International Conference in Bioinformatics and Systems Biology INCOBS 2010, February 19-21, 2010 at Annamalai University, Annamalai Nagar, Tamil Nadu.
Miscellaneous

Membership/Associations

  • Society of Biological Chemists (India) (Membership ID: 3391)
  • Society for Mitochondrial Research and Medicine- India (ID: L/140/2015)
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