Back close

Development of Host-directed Therapies for Drug Resistant Klebsiella Pneumonia Infections

Dept/Center/Lab: Antimicrobial Resistance 

School: School of Biotechnology

Project Incharge:Dr. Geetha Kumar
Co-Project Incharge:Abhinand K.
Development of Host-directed Therapies for Drug Resistant Klebsiella Pneumonia Infections

In the escalating threat of antibiotic resistance, my Ph.D. research tackles drug-resistant Klebsiella pneumoniae infections, a global health crisis responsible for over 750,000 deaths annually due to resistance. The ability of K. pneumoniae to evade the immune system further complicates the situation, leading to high mortality rates and extended hospital stays. Recognition as a critical priority pathogen by the World Health Organization, further underscores the urgent need for innovative therapeutics against K. pneumoniae infections.

Our research is focused on understanding K. pneumoniae’s manipulation of the host immune response through epigenetic modifications, with specific emphasis on the role played by histone modifications. By identifying and inhibiting the key enzymes involved, we aim to develop drugs that restore the innate ability of the host to fight infection. Furthermore, we investigate the therapeutic potential of enhancing autophagy and macrophage polarization to reinforce the capacity of the host to combat drug-resistant K. pneumoniae effectively. Through drug screening and efficacy assessment, both individually and in combination with current antibiotics, our goal is to develop a novel therapeutic strategy against these life-threatening infections.

Related Projects

Benchtop Nanoscale patterning using soft lithography for the printing of DNA molecules
Benchtop Nanoscale patterning using soft lithography for the printing of DNA molecules
MFC- Caulobactercrescentus as an Electrogen in A Dual Chambered Microbial Fuel Cell With The Novel Proton Exchange Membrane
MFC- Caulobactercrescentus as an Electrogen in A Dual Chambered Microbial Fuel Cell With The Novel Proton Exchange Membrane
Proteasome inhibitors from natural products
Proteasome inhibitors from natural products
Label – Free Quantitative Proteomics Analysis to Study the Effect of Triclosan on Delta-Haemolysin: A Haemolytic Factor of Methicillin – Resistant Staphylococcus Aureus
Label – Free Quantitative Proteomics Analysis to Study the Effect of Triclosan on Delta-Haemolysin: A Haemolytic Factor of Methicillin – Resistant Staphylococcus Aureus
Expression, Purification And Refolding Of Recombinant Amidase In Escherichia Coli
Expression, Purification And Refolding Of Recombinant Amidase In Escherichia Coli
Admissions Apply Now