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Evaluation of salivary interleukin-6 in children with early childhood caries after treatment

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Contemporary Clinical Dentistry, Medknow Publications,

Source : Contemporary Clinical Dentistry, Medknow Publications, Volume 7, Number 2, p.198-202 (2016)

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Campus : Kochi

School : School of Dentistry, School of Medicine

Center : Amrita Institute of Medical Science

Department : Biochemistry, Conservative Dentistry and Endodontics, Paediatric Dentistry

Year : 2016

Abstract : Background: The role of cytokines as a marker in the oral inflammatory process in ECC has not been fully explored before and after full mouth rehabilitation. Aims: The aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with ECC and to compare its levels before and after comprehensive full mouth rehabilitation. Methods and Materials: Saliva samples were collected from children with ECC prior to dental treatment and 3-month post treatment. The salivary IL-6 levels were analyzed using the ELISA method. The gingival index was also timely recorded. Oral health awareness sessions were conducted for children and their parents at regular intervals during the 3-month study period. Statistical analysis used: Wilcoxon Signed Rank test compared the levels of salivary IL-6 while, the paired t test compared the values of gingival index before and after treatment. Results: The mean level of salivary IL-6 before and 3 months after treatment had reduced and this reduction was statistically significant (Plt; 0.000). The gingival index scores had also reduced significantly 3-months post treatment (Plt; 0.002). Conclusions: Children with ECC when completely rehabilitated and kept under frequent follow up, which includes reinforcement of oral hygiene measures and maintaining a low caries activity state, the level of inflammation (IL-6) can definitely be minimized and thereby improving the quality of life of affected children. © 2016 Contemporary Clinical Dentistry. Published by Wolters Kluwer - Medknow.

Cite this Research Publication : Medhini Menon, Dr. Balagopal Varma R., Dr. Sajitha Krishnan, Parvathy Kumaran, Sangeetha G. Bhat, Arun Mamachan Xavier, and Suresh Kumar J., “Evaluation of salivary interleukin-6 in children with early childhood caries after treatment”, Contemporary Clinical Dentistry, vol. 7, pp. 198-202, 2016.

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